OR5G3_HUMAN
ID OR5G3_HUMAN Reviewed; 314 AA.
AC P0C626;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Olfactory receptor 5G3;
DE AltName: Full=Olfactory receptor 5G6;
DE AltName: Full=Olfactory receptor OR11-213;
GN Name=OR5G3; Synonyms=OR5G3P, OR5G6P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [4]
RP POLYMORPHISM.
RX PubMed=12730696; DOI=10.1038/ng1160;
RA Menashe I., Man O., Lancet D., Gilad Y.;
RT "Different noses for different people.";
RL Nat. Genet. 34:143-144(2003).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: A single nucleotide deletion at position Leu-135 in the
CC gene coding for this protein produces a stop codon which is responsible
CC for functional diversity thus producing a pseudogene.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5G3P";
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DR EMBL; AB065498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P0C626; -.
DR SMR; P0C626; -.
DR GlyGen; P0C626; 1 site.
DR BioMuta; OR5G3; -.
DR DMDM; 166215773; -.
DR MassIVE; P0C626; -.
DR PRIDE; P0C626; -.
DR GeneCards; OR5G3; -.
DR HGNC; HGNC:15287; OR5G3.
DR neXtProt; NX_P0C626; -.
DR InParanoid; P0C626; -.
DR PhylomeDB; P0C626; -.
DR PathwayCommons; P0C626; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR ChiTaRS; OR5G3; human.
DR Pharos; P0C626; Tdark.
DR PRO; PR:P0C626; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0C626; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 5G3"
FT /id="PRO_0000315216"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..143
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..167
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 314 AA; 35647 MW; 1F1C00DF87258F8E CRC64;
MEDKNQTVVT EFLLLGLTDH PYQKIVLFFM FLFVYLITLG GNLGMITLIW IDPRLHTPMY
FFLRHLSFVD ICSSSSVVPK MLCNIFAEKK DITFLGCAAQ MWFFGLFEAA ECFLLAAMAY
DRYVAICKPL LYTLIMSQQV CMQLVVGPYA MALISTMTHT IFTFCLPFCG SNIINHFFCD
IFPLLSLACA DTWVNKFVLF VLAGAIGVLS GLIIMVSYIC ILMTILKIQT ADGKQKAFFT
CFSHLAAVSI LYGTLFLIYV RPSSSSSLGI YKVISLFYTV VIPMVNPLIY SLRNKEVKDA
FRRKIERKKF IIGR
