OR5H1_HUMAN
ID OR5H1_HUMAN Reviewed; 313 AA.
AC A6NKK0;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Olfactory receptor 5H1;
DE AltName: Full=HTPCRX14;
GN Name=OR5H1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 126-239, AND VARIANTS LEU-153 AND ILE-181.
RC TISSUE=Testis;
RX PubMed=1370859; DOI=10.1038/355453a0;
RA Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
RA Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A.,
RA Vassart G.;
RT "Expression of members of the putative olfactory receptor gene family in
RT mammalian germ cells.";
RL Nature 355:453-455(1992).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- INTERACTION:
CC A6NKK0; Q70IA6: MOB2; NbExp=3; IntAct=EBI-23725364, EBI-2558739;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5H1";
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DR EMBL; AC117460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X64988; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS33797.1; -.
DR RefSeq; NP_001005338.1; NM_001005338.1.
DR AlphaFoldDB; A6NKK0; -.
DR SMR; A6NKK0; -.
DR BioGRID; 117686; 40.
DR IntAct; A6NKK0; 1.
DR STRING; 9606.ENSP00000346575; -.
DR GlyGen; A6NKK0; 1 site.
DR iPTMnet; A6NKK0; -.
DR PhosphoSitePlus; A6NKK0; -.
DR BioMuta; OR5H1; -.
DR MassIVE; A6NKK0; -.
DR PaxDb; A6NKK0; -.
DR PeptideAtlas; A6NKK0; -.
DR PRIDE; A6NKK0; -.
DR Antibodypedia; 32126; 50 antibodies from 16 providers.
DR DNASU; 26341; -.
DR Ensembl; ENST00000641874.1; ENSP00000492953.1; ENSG00000231192.3.
DR GeneID; 26341; -.
DR KEGG; hsa:26341; -.
DR MANE-Select; ENST00000641874.1; ENSP00000492953.1; NM_001005338.2; NP_001005338.1.
DR UCSC; uc011bgt.2; human.
DR CTD; 26341; -.
DR GeneCards; OR5H1; -.
DR HGNC; HGNC:8346; OR5H1.
DR HPA; ENSG00000231192; Not detected.
DR neXtProt; NX_A6NKK0; -.
DR PharmGKB; PA32532; -.
DR VEuPathDB; HostDB:ENSG00000231192; -.
DR eggNOG; ENOG502T9JQ; Eukaryota.
DR GeneTree; ENSGT00950000182874; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; A6NKK0; -.
DR OMA; HAIIHES; -.
DR OrthoDB; 865116at2759; -.
DR PhylomeDB; A6NKK0; -.
DR TreeFam; TF352737; -.
DR PathwayCommons; A6NKK0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26341; 12 hits in 578 CRISPR screens.
DR GenomeRNAi; 26341; -.
DR Pharos; A6NKK0; Tdark.
DR PRO; PR:A6NKK0; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; A6NKK0; protein.
DR Bgee; ENSG00000231192; Expressed in right uterine tube and 1 other tissue.
DR ExpressionAtlas; A6NKK0; differential.
DR Genevisible; A6NKK0; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 5H1"
FT /id="PRO_0000310867"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 148
FT /note="S -> T (in dbSNP:rs5009896)"
FT /id="VAR_037089"
FT VARIANT 153
FT /note="I -> L (in dbSNP:rs9845327)"
FT /evidence="ECO:0000269|PubMed:1370859"
FT /id="VAR_037091"
FT VARIANT 181
FT /note="T -> I (in dbSNP:rs9826076)"
FT /evidence="ECO:0000269|PubMed:1370859"
FT /id="VAR_037092"
FT VARIANT 230
FT /note="S -> T (in dbSNP:rs9849637)"
FT /id="VAR_037093"
FT CONFLICT 228
FT /note="K -> R (in Ref. 2; X64988)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 313 AA; 35387 MW; ABF576A58DF9BFF0 CRC64;
MEEENATLLT EFVLTGFLYQ PQWKIPLFLA FLVIYLITIM GNLGLIAVIW KDPHLHIPMY
LLLGNLAFVD AWISSTVTPK MLNNFLAKSK MISLSECKIQ FFSFAISVTT ECFLLATMAY
DRYVAICKPL LYPAIMTNGL CIRLLILSYV GGILHALIHE GFLFRLTFCN SNIVHHIYCD
TIPLSKISCT DSSINFLMVF IFSGSIQVFS IVTILVSYTF VLFAILKKKS DKGVRKAFST
CGAHLFSVSL YYGPLLFIYV GPASPQADDQ DMVEPLFYTV IIPLLNPIIY SLRNKQVTVS
FTKMLKKHVK VSY
