OR5H2_HUMAN
ID OR5H2_HUMAN Reviewed; 314 AA.
AC Q8NGV7; Q6IF87;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 5H2;
DE AltName: Full=Olfactory receptor OR3-10;
GN Name=OR5H2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5H2";
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DR EMBL; AB065666; BAC05892.1; -; Genomic_DNA.
DR EMBL; AC117473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004375; DAA04773.1; -; Genomic_DNA.
DR RefSeq; NP_001005482.1; NM_001005482.1.
DR AlphaFoldDB; Q8NGV7; -.
DR SMR; Q8NGV7; -.
DR STRING; 9606.ENSP00000347418; -.
DR GlyGen; Q8NGV7; 1 site.
DR BioMuta; OR5H2; -.
DR DMDM; 212276497; -.
DR MassIVE; Q8NGV7; -.
DR PaxDb; Q8NGV7; -.
DR PeptideAtlas; Q8NGV7; -.
DR PRIDE; Q8NGV7; -.
DR Antibodypedia; 66603; 79 antibodies from 17 providers.
DR DNASU; 79310; -.
DR Ensembl; ENST00000355273.3; ENSP00000347418.3; ENSG00000197938.6.
DR GeneID; 79310; -.
DR KEGG; hsa:79310; -.
DR UCSC; uc003dsj.1; human.
DR CTD; 79310; -.
DR GeneCards; OR5H2; -.
DR HGNC; HGNC:14752; OR5H2.
DR HPA; ENSG00000197938; Not detected.
DR neXtProt; NX_Q8NGV7; -.
DR PharmGKB; PA32533; -.
DR VEuPathDB; HostDB:ENSG00000197938; -.
DR eggNOG; ENOG502T9JQ; Eukaryota.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGV7; -.
DR OrthoDB; 865116at2759; -.
DR PhylomeDB; Q8NGV7; -.
DR TreeFam; TF352737; -.
DR PathwayCommons; Q8NGV7; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 79310; 7 hits in 664 CRISPR screens.
DR GeneWiki; OR5H2; -.
DR GenomeRNAi; 79310; -.
DR Pharos; Q8NGV7; Tdark.
DR PRO; PR:Q8NGV7; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8NGV7; protein.
DR Bgee; ENSG00000197938; Expressed in granulocyte and 2 other tissues.
DR ExpressionAtlas; Q8NGV7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 5H2"
FT /id="PRO_0000150596"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..54
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 55..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 102..184
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 230
FT /note="I -> V (in dbSNP:rs16839214)"
FT /id="VAR_053195"
FT VARIANT 266
FT /note="R -> C (in dbSNP:rs17787561)"
FT /id="VAR_053196"
FT VARIANT 286
FT /note="I -> V (in dbSNP:rs16839611)"
FT /id="VAR_053197"
SQ SEQUENCE 314 AA; 35974 MW; CBAD88D263E03204 CRC64;
MSNEDMEQDN TTLLTEFVLT GLTYQPEWKM PLFLVFLVIY LITIVWNLGL IALIWNDPQL
HIPMYFFLGS LAFVDAWISS TVTPKMLVNF LAKNRMISLS ECMIQFFSFA FGGTTECFLL
ATMAYDRYVA ICKPLLYPVI MNNSLCIRLL AFSFLGGFLH ALIHEVLIFR LTFCNSNIIH
HFYCDIIPLF MISCTDPSIN FLMVFILSGS IQVFTIVTVL NSYTFALFTI LKKKSVRGVR
KAFSTCGAHL LSVSLYYGPL IFMYLRPASP QADDQDMIDS VFYTIIIPLL NPIIYSLRNK
QVIDSFTKMV KRNV
