OR5H6_HUMAN
ID OR5H6_HUMAN Reviewed; 325 AA.
AC Q8NGV6; Q6IF88;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Olfactory receptor 5H6;
DE AltName: Full=Olfactory receptor OR3-11;
GN Name=OR5H6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-17 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05893.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5H6";
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DR EMBL; AB065667; BAC05893.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC137523; AAI37524.1; -; mRNA.
DR EMBL; BC137524; AAI37525.1; -; mRNA.
DR EMBL; BK004374; DAA04772.1; -; Genomic_DNA.
DR RefSeq; NP_001005479.1; NM_001005479.1.
DR RefSeq; XP_011511420.1; XM_011513118.2.
DR AlphaFoldDB; Q8NGV6; -.
DR SMR; Q8NGV6; -.
DR IntAct; Q8NGV6; 1.
DR STRING; 9606.ENSP00000373196; -.
DR GlyGen; Q8NGV6; 1 site.
DR iPTMnet; Q8NGV6; -.
DR PhosphoSitePlus; Q8NGV6; -.
DR BioMuta; OR5H6; -.
DR DMDM; 223590117; -.
DR PaxDb; Q8NGV6; -.
DR PeptideAtlas; Q8NGV6; -.
DR PRIDE; Q8NGV6; -.
DR Antibodypedia; 58698; 45 antibodies from 16 providers.
DR DNASU; 79295; -.
DR Ensembl; ENST00000642105.1; ENSP00000493340.1; ENSG00000230301.6.
DR GeneID; 79295; -.
DR KEGG; hsa:79295; -.
DR UCSC; uc003dsi.1; human.
DR CTD; 79295; -.
DR GeneCards; OR5H6; -.
DR HGNC; HGNC:14767; OR5H6.
DR HPA; ENSG00000230301; Not detected.
DR neXtProt; NX_Q8NGV6; -.
DR PharmGKB; PA32537; -.
DR VEuPathDB; HostDB:ENSG00000230301; -.
DR eggNOG; ENOG502T9JQ; Eukaryota.
DR GeneTree; ENSGT00950000182874; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGV6; -.
DR OrthoDB; 865116at2759; -.
DR PhylomeDB; Q8NGV6; -.
DR TreeFam; TF352737; -.
DR PathwayCommons; Q8NGV6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGV6; -.
DR BioGRID-ORCS; 79295; 7 hits in 587 CRISPR screens.
DR GeneWiki; OR5H6; -.
DR GenomeRNAi; 79295; -.
DR Pharos; Q8NGV6; Tdark.
DR PRO; PR:Q8NGV6; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8NGV6; protein.
DR Bgee; ENSG00000230301; Expressed in placenta.
DR ExpressionAtlas; Q8NGV6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..325
FT /note="Olfactory receptor 5H6"
FT /id="PRO_0000150597"
FT TOPO_DOM 1..41
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..115
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..155
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..212
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..325
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 113..205
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 46
FT /note="A -> E (in dbSNP:rs4241472)"
FT /id="VAR_054343"
FT VARIANT 88
FT /note="S -> L (in dbSNP:rs2173236)"
FT /id="VAR_060008"
FT VARIANT 88
FT /note="S -> W (in dbSNP:rs2173236)"
FT /id="VAR_060009"
FT VARIANT 145
FT /note="A -> P (in dbSNP:rs9289564)"
FT /id="VAR_054344"
FT VARIANT 179
FT /note="S -> L (in dbSNP:rs16846784)"
FT /id="VAR_054345"
FT VARIANT 195
FT /note="C -> R (in dbSNP:rs9853887)"
FT /id="VAR_054346"
FT VARIANT 272
FT /note="T -> A (in dbSNP:rs9853906)"
FT /id="VAR_054347"
FT VARIANT 285
FT /note="D -> N (in dbSNP:rs9871143)"
FT /id="VAR_054348"
SQ SEQUENCE 325 AA; 36713 MW; E54F8A835C903407 CRC64;
MFLYLCFIFQ RTCSEEMEEE NATLLTEFVL TGFLHQPDCK IPLFLAFLVI YLITIMGNLG
LIVLIWKDPH LHIPMYLFLG SLAFVDASLS STVTPKMLIN FLAKSKMISL SECMVQFFSL
VTTVTTECFL LATMAYDRYV AICKALLYPV IMTNELCIQL LVLSFIGGLL HALIHEAFSF
RLTFCNSNII QHFYCDIIPL LKISCTDSSI NFLMVFIFAG SVQVFTIGTI LISYTIILFT
ILEKKSIKGI RKAVSTCGAH LLSVSLYYGP LTFKYLGSAS PQADDQDMME SLFYTVIVPL
LNPMIYSLRN KQVIASFTKM FKSNV
