OR5H8_HUMAN
ID OR5H8_HUMAN Reviewed; 308 AA.
AC P0DN80;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 17-FEB-2016, sequence version 1.
DT 03-AUG-2022, entry version 24.
DE RecName: Full=Olfactory receptor 5H8;
DE AltName: Full=Olfactory receptor 5H8 pseudogene;
DE AltName: Full=Olfactory receptor OR3-7 {ECO:0000303|PubMed:14983052};
GN Name=OR5H8 {ECO:0000312|HGNC:HGNC:14773}; Synonyms=OR5H8P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [4]
RP POLYMORPHISM.
RX PubMed=22908908; DOI=10.1186/1471-2164-13-414;
RA Olender T., Waszak S.M., Viavant M., Khen M., Ben-Asher E., Reyes A.,
RA Nativ N., Wysocki C.J., Ge D., Lancet D.;
RT "Personal receptor repertoires: olfaction as a model.";
RL BMC Genomics 13:414-414(2012).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- POLYMORPHISM: Segregating pseudogene, locus showing both intact and
CC pseudogene forms in the population. A single nucleotide deletion at
CC position Lys-229 in the gene coding for this protein is responsible for
CC functional diversity, producing a pseudogene.
CC {ECO:0000269|PubMed:22908908}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5H8";
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DR EMBL; AC117473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P0DN80; -.
DR SMR; P0DN80; -.
DR IntAct; P0DN80; 2.
DR BioMuta; OR5H8; -.
DR MassIVE; P0DN80; -.
DR PRIDE; P0DN80; -.
DR GeneCards; OR5H8; -.
DR HGNC; HGNC:14773; OR5H8.
DR neXtProt; NX_P0DN80; -.
DR PathwayCommons; P0DN80; -.
DR SignaLink; P0DN80; -.
DR Pharos; P0DN80; Tdark.
DR PRO; PR:P0DN80; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0DN80; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..308
FT /note="Olfactory receptor 5H8"
FT /id="PRO_0000435454"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..195
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..270
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 308 AA; 34772 MW; B4C4C400BE2BEB26 CRC64;
MDDENATLLT EFVLTGLTYQ SEWKIPLFLA FLVIYLITIM ANLGLIAVIW KDSHLHIPMY
LFLGSLAFVD AWLSSSVTPK MLISFLAKSM IISVSECKIQ FFSFGISGTT ECFLLATMAY
DRYVAICKPL LYPVIMTNGL CIWLLVLSFI GGFLHALIHE GILFRLTFCN SNIIHHFYCD
IIPLLKISCT DPSINFLMLF ILSGSIQVFT ILTVLVSYTF VLFTILKKKA KDIRKAFSTC
GAHLLSVSLY YGPLLFMYVH PASPQADDQD MVESLFYTVI IPFLNPIIYS LRNKQVIDSL
TKTLKGNV
