OR5I1_HUMAN
ID OR5I1_HUMAN Reviewed; 314 AA.
AC Q13606; Q6IEU4;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Olfactory receptor 5I1;
DE AltName: Full=Olfactory receptor OR11-159;
DE AltName: Full=Olfactory receptor-like protein OLF1;
GN Name=OR5I1; Synonyms=OLF1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9017400; DOI=10.1093/genetics/145.1.185;
RA Issel-Tarver L., Rine J.;
RT "The evolution of mammalian olfactory receptor genes.";
RL Genetics 145:185-195(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5I1";
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DR EMBL; U56420; AAB01214.1; -; Genomic_DNA.
DR EMBL; BC069093; AAH69093.1; -; mRNA.
DR EMBL; BK004518; DAA04916.1; -; Genomic_DNA.
DR CCDS; CCDS7949.1; -.
DR RefSeq; NP_006628.1; NM_006637.1.
DR AlphaFoldDB; Q13606; -.
DR SMR; Q13606; -.
DR STRING; 9606.ENSP00000301532; -.
DR GlyGen; Q13606; 1 site.
DR iPTMnet; Q13606; -.
DR PhosphoSitePlus; Q13606; -.
DR BioMuta; OR5I1; -.
DR DMDM; 2495050; -.
DR MassIVE; Q13606; -.
DR PaxDb; Q13606; -.
DR PeptideAtlas; Q13606; -.
DR PRIDE; Q13606; -.
DR Antibodypedia; 58950; 106 antibodies from 22 providers.
DR DNASU; 10798; -.
DR Ensembl; ENST00000301532.3; ENSP00000301532.3; ENSG00000167825.3.
DR GeneID; 10798; -.
DR KEGG; hsa:10798; -.
DR MANE-Select; ENST00000301532.3; ENSP00000301532.3; NM_006637.1; NP_006628.1.
DR UCSC; uc010ris.2; human.
DR CTD; 10798; -.
DR GeneCards; OR5I1; -.
DR HGNC; HGNC:8347; OR5I1.
DR HPA; ENSG00000167825; Not detected.
DR MIM; 608496; gene.
DR neXtProt; NX_Q13606; -.
DR OpenTargets; ENSG00000167825; -.
DR PharmGKB; PA32540; -.
DR VEuPathDB; HostDB:ENSG00000167825; -.
DR eggNOG; ENOG502SIQS; Eukaryota.
DR GeneTree; ENSGT01050000244804; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q13606; -.
DR OMA; MSRGICM; -.
DR OrthoDB; 952595at2759; -.
DR PhylomeDB; Q13606; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q13606; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 10798; 9 hits in 674 CRISPR screens.
DR GeneWiki; OR5I1; -.
DR GenomeRNAi; 10798; -.
DR Pharos; Q13606; Tdark.
DR PRO; PR:Q13606; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q13606; protein.
DR Bgee; ENSG00000167825; Expressed in cell and 7 other tissues.
DR ExpressionAtlas; Q13606; baseline and differential.
DR Genevisible; Q13606; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; NAS:ProtInc.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 5I1"
FT /id="PRO_0000150598"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..191
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 6
FT /note="R -> G (in dbSNP:rs17597625)"
FT /id="VAR_053198"
FT VARIANT 50
FT /note="L -> S (in dbSNP:rs4367963)"
FT /id="VAR_053199"
FT VARIANT 76
FT /note="F -> S (in dbSNP:rs9666086)"
FT /id="VAR_024101"
FT VARIANT 306
FT /note="V -> I (in dbSNP:rs9665861)"
FT /id="VAR_053200"
SQ SEQUENCE 314 AA; 36049 MW; 334BE9BF3D9A4D63 CRC64;
MEFTDRNYTL VTEFILLGFP TRPELQIVLF LMFLTLYAII LIGNIGLMLL IRIDPHLQTP
MYFFLSNLSF VDLCYFSDIV PKMLVNFLSE NKSISYYGCA LQFYFFCTFA DTESFILAAM
AYDRYVAICN PLLYTVVMSR GICMRLIVLS YLGGNMSSLV HTSFAFILKY CDKNVINHFF
CDLPPLLKLS CTDTTINEWL LSTYGSSVEI ICFIIIIISY FFILLSVLKI RSFSGRKKTF
STCASHLTSV TIYQGTLLFI YSRPSYLYSP NTDKIISVFY TIFIPVLNPL IYSLRNKDVK
DAAEKVLRSK VDSS
