OR5J2_HUMAN
ID OR5J2_HUMAN Reviewed; 312 AA.
AC Q8NH18; Q6IEU5;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 5J2;
DE AltName: Full=Olfactory receptor OR11-266;
GN Name=OR5J2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5J2";
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DR EMBL; AB065595; BAC05823.1; -; Genomic_DNA.
DR EMBL; BK004517; DAA04915.1; -; Genomic_DNA.
DR CCDS; CCDS31522.1; -.
DR RefSeq; NP_001005492.1; NM_001005492.1.
DR AlphaFoldDB; Q8NH18; -.
DR SMR; Q8NH18; -.
DR STRING; 9606.ENSP00000310788; -.
DR GlyGen; Q8NH18; 1 site.
DR PhosphoSitePlus; Q8NH18; -.
DR BioMuta; OR5J2; -.
DR DMDM; 38372500; -.
DR MassIVE; Q8NH18; -.
DR PaxDb; Q8NH18; -.
DR PeptideAtlas; Q8NH18; -.
DR PRIDE; Q8NH18; -.
DR Antibodypedia; 72064; 30 antibodies from 16 providers.
DR DNASU; 282775; -.
DR Ensembl; ENST00000312298.1; ENSP00000310788.1; ENSG00000174957.1.
DR GeneID; 282775; -.
DR KEGG; hsa:282775; -.
DR MANE-Select; ENST00000312298.1; ENSP00000310788.1; NM_001005492.1; NP_001005492.1.
DR UCSC; uc010rjb.2; human.
DR CTD; 282775; -.
DR DisGeNET; 282775; -.
DR GeneCards; OR5J2; -.
DR HGNC; HGNC:19612; OR5J2.
DR HPA; ENSG00000174957; Not detected.
DR neXtProt; NX_Q8NH18; -.
DR PharmGKB; PA134982020; -.
DR VEuPathDB; HostDB:ENSG00000174957; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01050000244860; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NH18; -.
DR OMA; WIGGIVN; -.
DR OrthoDB; 1107599at2759; -.
DR PhylomeDB; Q8NH18; -.
DR TreeFam; TF352748; -.
DR PathwayCommons; Q8NH18; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 282775; 7 hits in 673 CRISPR screens.
DR GeneWiki; OR5J2; -.
DR GenomeRNAi; 282775; -.
DR Pharos; Q8NH18; Tdark.
DR PRO; PR:Q8NH18; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH18; protein.
DR Bgee; ENSG00000174957; Expressed in C1 segment of cervical spinal cord.
DR ExpressionAtlas; Q8NH18; baseline and differential.
DR Genevisible; Q8NH18; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 5J2"
FT /id="PRO_0000150599"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 136
FT /note="M -> I (in dbSNP:rs12279899)"
FT /id="VAR_034226"
SQ SEQUENCE 312 AA; 34808 MW; F21D7E3DB3D02B70 CRC64;
MADDNFTVVT EFILLGLTDH AELKAVLFVV FLVIYAITLL RNLGMILLIQ ITSKLHTPMY
FLLSCLSFVD ACYSSAIAPK MLVNLLVVKA TISFSACMVQ HLCFGVFITT EGFLLSVMAY
DRYVAIVSPL LYTVAMSDRK CVELVTGSWI GGIVNTLIHT ISLRRLSFCR LNAVSHFFCD
IPSLLKLSCS DTSMNELLLL TFSGVIAMAT FLTVIISYIF IAFASLRIHS ASGRQQAFST
CASHLTAVTI FYGTLIFSYI QPSSQYFVEQ EKVVSMFYTL GIPMLNLLIH SLRNKDVKEA
VKRAIEMKHF LC
