OR5K1_HUMAN
ID OR5K1_HUMAN Reviewed; 308 AA.
AC Q8NHB7; B9EGY5; Q6IF46;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 5K1;
DE AltName: Full=HTPCRX10;
DE AltName: Full=Olfactory receptor OR3-8;
GN Name=OR5K1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 126-237.
RC TISSUE=Testis;
RX PubMed=1370859; DOI=10.1038/355453a0;
RA Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
RA Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A.,
RA Vassart G.;
RT "Expression of members of the putative olfactory receptor gene family in
RT mammalian germ cells.";
RL Nature 355:453-455(1992).
RN [6]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [7]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05718.1; Type=Frameshift; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5K1";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065458; BAC05718.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AC074274; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79862.1; -; Genomic_DNA.
DR EMBL; BC136918; AAI36919.1; -; mRNA.
DR EMBL; BC136919; AAI36920.1; -; mRNA.
DR EMBL; X64984; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BK004416; DAA04814.1; -; Genomic_DNA.
DR CCDS; CCDS43115.1; -.
DR RefSeq; NP_001004736.2; NM_001004736.3.
DR AlphaFoldDB; Q8NHB7; -.
DR SMR; Q8NHB7; -.
DR STRING; 9606.ENSP00000373193; -.
DR ChEMBL; CHEMBL3721312; -.
DR GlyGen; Q8NHB7; 1 site.
DR BioMuta; OR5K1; -.
DR DMDM; 317373404; -.
DR MassIVE; Q8NHB7; -.
DR PaxDb; Q8NHB7; -.
DR PeptideAtlas; Q8NHB7; -.
DR PRIDE; Q8NHB7; -.
DR ProteomicsDB; 73696; -.
DR Antibodypedia; 62078; 47 antibodies from 14 providers.
DR DNASU; 26339; -.
DR Ensembl; ENST00000332650.5; ENSP00000373193.2; ENSG00000232382.2.
DR Ensembl; ENST00000642057.1; ENSP00000493267.1; ENSG00000232382.2.
DR GeneID; 26339; -.
DR KEGG; hsa:26339; -.
DR MANE-Select; ENST00000642057.1; ENSP00000493267.1; NM_001004736.4; NP_001004736.2.
DR UCSC; uc003dsm.4; human.
DR CTD; 26339; -.
DR GeneCards; OR5K1; -.
DR HGNC; HGNC:8349; OR5K1.
DR HPA; ENSG00000232382; Not detected.
DR neXtProt; NX_Q8NHB7; -.
DR OpenTargets; ENSG00000232382; -.
DR PharmGKB; PA32542; -.
DR VEuPathDB; HostDB:ENSG00000232382; -.
DR eggNOG; ENOG502T6QX; Eukaryota.
DR GeneTree; ENSGT00950000182874; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NHB7; -.
DR OMA; KENHTIK; -.
DR OrthoDB; 848013at2759; -.
DR PhylomeDB; Q8NHB7; -.
DR TreeFam; TF352737; -.
DR PathwayCommons; Q8NHB7; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26339; 17 hits in 586 CRISPR screens.
DR GeneWiki; OR5K1; -.
DR GenomeRNAi; 26339; -.
DR Pharos; Q8NHB7; Tdark.
DR PRO; PR:Q8NHB7; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8NHB7; protein.
DR Bgee; ENSG00000232382; Expressed in calcaneal tendon and 6 other tissues.
DR ExpressionAtlas; Q8NHB7; baseline and differential.
DR Genevisible; Q8NHB7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..308
FT /note="Olfactory receptor 5K1"
FT /id="PRO_0000150600"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 308 AA; 35185 MW; 132F07610D91115A CRC64;
MAEENHTMKN EFILTGFTDH PELKTLLFVV FFAIYLITVV GNISLVALIF THRRLHTPMY
IFLGNLALVD SCCACAITPK MLENFFSENK RISLYECAVQ FYFLCTVETA DCFLLAAMAY
DRYVAICNPL QYHIMMSKKL CIQMTTGAFI AGNLHSMIHV GLVFRLVFCG SNHINHFYCD
ILPLYRLSCV DPYINELVLF IFSGSVQVFT IGSVLISYLY ILLTIFKMKS KEGRAKAFST
CASHFLSVSL FYGSLFFMYV RPNLLEEGDK DIPAAILFTI VVPLLNPFIY SLRNREVISV
LRKILMKK
