OR5K2_HUMAN
ID OR5K2_HUMAN Reviewed; 316 AA.
AC Q8NHB8; B2RN70; Q6IF47;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 3.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Olfactory receptor 5K2;
DE AltName: Full=Olfactory receptor OR3-9;
GN Name=OR5K2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- INTERACTION:
CC Q8NHB8; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12176235, EBI-16439278;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5K2";
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DR EMBL; AB065457; BAC05717.1; -; Genomic_DNA.
DR EMBL; AC074274; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79861.1; -; Genomic_DNA.
DR EMBL; BC136724; AAI36725.1; -; mRNA.
DR EMBL; BC136725; AAI36726.1; -; mRNA.
DR EMBL; BK004415; DAA04813.1; -; Genomic_DNA.
DR CCDS; CCDS33804.1; -.
DR RefSeq; NP_001004737.1; NM_001004737.1.
DR AlphaFoldDB; Q8NHB8; -.
DR SMR; Q8NHB8; -.
DR BioGRID; 135342; 23.
DR IntAct; Q8NHB8; 1.
DR STRING; 9606.ENSP00000393889; -.
DR GlyGen; Q8NHB8; 1 site.
DR iPTMnet; Q8NHB8; -.
DR PhosphoSitePlus; Q8NHB8; -.
DR BioMuta; OR5K2; -.
DR DMDM; 134047867; -.
DR MassIVE; Q8NHB8; -.
DR PaxDb; Q8NHB8; -.
DR PeptideAtlas; Q8NHB8; -.
DR PRIDE; Q8NHB8; -.
DR Antibodypedia; 58704; 24 antibodies from 11 providers.
DR DNASU; 402135; -.
DR Ensembl; ENST00000427338.3; ENSP00000393889.1; ENSG00000231861.3.
DR GeneID; 402135; -.
DR KEGG; hsa:402135; -.
DR MANE-Select; ENST00000427338.3; ENSP00000393889.1; NM_001004737.1; NP_001004737.1.
DR UCSC; uc011bgx.3; human.
DR CTD; 402135; -.
DR GeneCards; OR5K2; -.
DR HGNC; HGNC:14774; OR5K2.
DR HPA; ENSG00000231861; Not detected.
DR neXtProt; NX_Q8NHB8; -.
DR PharmGKB; PA32543; -.
DR VEuPathDB; HostDB:ENSG00000231861; -.
DR eggNOG; ENOG502T6QX; Eukaryota.
DR GeneTree; ENSGT00950000182874; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NHB8; -.
DR OMA; IFFIYIR; -.
DR OrthoDB; 848013at2759; -.
DR PhylomeDB; Q8NHB8; -.
DR TreeFam; TF352737; -.
DR PathwayCommons; Q8NHB8; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NHB8; -.
DR BioGRID-ORCS; 402135; 275 hits in 586 CRISPR screens.
DR GeneWiki; OR5K2; -.
DR GenomeRNAi; 402135; -.
DR Pharos; Q8NHB8; Tdark.
DR PRO; PR:Q8NHB8; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8NHB8; protein.
DR Bgee; ENSG00000231861; Expressed in popliteal artery and 80 other tissues.
DR ExpressionAtlas; Q8NHB8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 5K2"
FT /id="PRO_0000150601"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 53
FT /note="C -> R (in Ref. 2; AC074274)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 316 AA; 35763 MW; 3FB40EFC6C9DA2A3 CRC64;
MVEENHTMKN EFILTGFTDH PELKTLLFVV FFAIYLITVV GNISLVALIF THCRLHTPMY
IFLGNLALVD SCCACAITPK MLENFFSEGK RISLYECAVQ FYFLCTVETA DCFLLAAVAY
DRYVAICNPL QYHIMMSKKL CIQMTTGAFI AGNLHSMIHV GLVFRLVFCG LNHINHFYCD
TLPLYRLSCV DPFINELVLF IFSGSVQVFT IGSVLISYLY ILLTIFRMKS KEGRAKAFST
CASHFSSVSL FYGSIFFLYI RPNLLEEGGN DIPAAILFTI VVPLLNPFIY SLRNKEVISV
LRKILLKIKS QGSVNK
