OR5K3_HUMAN
ID OR5K3_HUMAN Reviewed; 321 AA.
AC A6NET4;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Olfactory receptor 5K3;
GN Name=OR5K3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5K3";
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DR EMBL; AC108730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS33803.1; -.
DR RefSeq; NP_001005516.1; NM_001005516.1.
DR AlphaFoldDB; A6NET4; -.
DR SMR; A6NET4; -.
DR STRING; 9606.ENSP00000373194; -.
DR GlyGen; A6NET4; 1 site.
DR BioMuta; OR5K3; -.
DR MassIVE; A6NET4; -.
DR PaxDb; A6NET4; -.
DR PeptideAtlas; A6NET4; -.
DR PRIDE; A6NET4; -.
DR Antibodypedia; 58701; 45 antibodies from 14 providers.
DR DNASU; 403277; -.
DR Ensembl; ENST00000383695.1; ENSP00000373194.1; ENSG00000206536.1.
DR GeneID; 403277; -.
DR KEGG; hsa:403277; -.
DR MANE-Select; ENST00000383695.1; ENSP00000373194.1; NM_001005516.1; NP_001005516.1.
DR UCSC; uc011bgw.2; human.
DR CTD; 403277; -.
DR GeneCards; OR5K3; -.
DR HGNC; HGNC:31290; OR5K3.
DR HPA; ENSG00000206536; Not detected.
DR neXtProt; NX_A6NET4; -.
DR PharmGKB; PA134984948; -.
DR VEuPathDB; HostDB:ENSG00000206536; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000182874; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; A6NET4; -.
DR OMA; RITLYEC; -.
DR OrthoDB; 884649at2759; -.
DR PhylomeDB; A6NET4; -.
DR TreeFam; TF352737; -.
DR PathwayCommons; A6NET4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 403277; 10 hits in 636 CRISPR screens.
DR GenomeRNAi; 403277; -.
DR Pharos; A6NET4; Tdark.
DR PRO; PR:A6NET4; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; A6NET4; protein.
DR Bgee; ENSG00000206536; Expressed in calcaneal tendon and 5 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..321
FT /note="Olfactory receptor 5K3"
FT /id="PRO_0000310455"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 44
FT /note="G -> D (in dbSNP:rs13068323)"
FT /id="VAR_037044"
SQ SEQUENCE 321 AA; 36711 MW; 812EDD08376360A7 CRC64;
MNKENHSLIA EFILTGFTYH PKLKTVLFVV FFAIYLITMV GNIGLVALIY IEQRLHTPMY
IFLGNLVLMD SCCSSAITPK MLENFFSEDK RITLYECMAQ FYFLCLAETT DCFLLAAMAY
DCYVAICNPL QYHTMMSKTL CIQMTAGAYL AGNLHPMIEV EFLLRLTFCG SHQINHFFCD
VLPLYRLSCI NPYINELVLF ILAGSIQIFT IVLVSYFYIL FTIFTMKSKE GRGKALSTCA
SHFLSVSIFC DSLLFMYARP GAVNEGDKDI PVAIFYTLVI PLLNPFIYSL RNKEVINIMK
KIMKKRKFCH ILKQMSSPLA T
