OR5L1_HUMAN
ID OR5L1_HUMAN Reviewed; 311 AA.
AC Q8NGL2; B2RNK6; Q6IFD0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 5L1;
DE AltName: Full=OST262;
DE AltName: Full=Olfactory receptor OR11-151;
GN Name=OR5L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5L1";
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DR EMBL; AB065780; BAC06000.1; -; Genomic_DNA.
DR EMBL; BC109249; AAI09250.1; -; mRNA.
DR EMBL; BC109250; AAI09251.1; -; mRNA.
DR EMBL; BC136939; AAI36940.1; -; mRNA.
DR EMBL; BK004332; DAA04730.1; -; Genomic_DNA.
DR RefSeq; NP_001004738.1; NM_001004738.2.
DR AlphaFoldDB; Q8NGL2; -.
DR SMR; Q8NGL2; -.
DR BioGRID; 128535; 8.
DR STRING; 9606.ENSP00000335529; -.
DR GlyGen; Q8NGL2; 2 sites.
DR iPTMnet; Q8NGL2; -.
DR PhosphoSitePlus; Q8NGL2; -.
DR BioMuta; OR5L1; -.
DR DMDM; 38372721; -.
DR MassIVE; Q8NGL2; -.
DR PaxDb; Q8NGL2; -.
DR PeptideAtlas; Q8NGL2; -.
DR PRIDE; Q8NGL2; -.
DR Antibodypedia; 78667; 52 antibodies from 14 providers.
DR DNASU; 219437; -.
DR Ensembl; ENST00000625203.2; ENSP00000485319.1; ENSG00000279395.3.
DR GeneID; 219437; -.
DR KEGG; hsa:219437; -.
DR MANE-Select; ENST00000625203.2; ENSP00000485319.1; NM_001004738.2; NP_001004738.1.
DR UCSC; uc001nhw.1; human.
DR CTD; 219437; -.
DR GeneCards; OR5L1; -.
DR HGNC; HGNC:8350; OR5L1.
DR HPA; ENSG00000279395; Not detected.
DR neXtProt; NX_Q8NGL2; -.
DR PharmGKB; PA32544; -.
DR VEuPathDB; HostDB:ENSG00000279395; -.
DR eggNOG; ENOG502T9KN; Eukaryota.
DR GeneTree; ENSGT01050000244804; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGL2; -.
DR OMA; VLSIYCR; -.
DR OrthoDB; 954078at2759; -.
DR PhylomeDB; Q8NGL2; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGL2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219437; 8 hits in 614 CRISPR screens.
DR GeneWiki; OR5L1; -.
DR GenomeRNAi; 219437; -.
DR Pharos; Q8NGL2; Tdark.
DR PRO; PR:Q8NGL2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGL2; protein.
DR Bgee; ENSG00000279395; Expressed in gonad.
DR ExpressionAtlas; Q8NGL2; differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 5L1"
FT /id="PRO_0000150602"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 46
FT /note="I -> F (in dbSNP:rs2869020)"
FT /id="VAR_034227"
FT VARIANT 54
FT /note="R -> W (in dbSNP:rs34961497)"
FT /id="VAR_062044"
FT VARIANT 287
FT /note="S -> P (in dbSNP:rs12790505)"
FT /id="VAR_034228"
SQ SEQUENCE 311 AA; 34559 MW; 3F81C01BF5578119 CRC64;
MGKENCTTVA EFILLGLSDV PELRVCLFLL FLLIYGVTLL ANLGMIALIQ VSSRLHTPMY
FFLSHLSSVD FCYSSIIVPK MLANIFNKDK AISFLGCMVQ FYLFCTCVVT EVFLLAVMAY
DRFVAICNPL LYTVTMSWKV RVELASCCYF CGTVCSLIHL CLALRIPFYR SNVINHFFCD
LPPVLSLACS DITVNETLLF LVATLNESVT IMIILTSYLL ILTTILKMGS AEGRHKAFST
CASHLTAITV FHGTVLSIYC RPSSGNSGDA DKVATVFYTV VIPMLNSVIY SLRNKDVKEA
LRKVMGSKIH S
