OR5M1_HUMAN
ID OR5M1_HUMAN Reviewed; 315 AA.
AC Q8NGP8; Q6IF60; Q96RB6;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Olfactory receptor 5M1;
DE AltName: Full=OST050;
DE AltName: Full=Olfactory receptor OR11-208;
GN Name=OR5M1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5M1";
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DR EMBL; AB065742; BAC05962.1; -; Genomic_DNA.
DR EMBL; AF399522; AAK95007.1; -; Genomic_DNA.
DR EMBL; BK004402; DAA04800.1; -; Genomic_DNA.
DR CCDS; CCDS53631.1; -.
DR RefSeq; NP_001004740.1; NM_001004740.1.
DR AlphaFoldDB; Q8NGP8; -.
DR SMR; Q8NGP8; -.
DR STRING; 9606.ENSP00000435416; -.
DR GlyGen; Q8NGP8; 1 site.
DR iPTMnet; Q8NGP8; -.
DR PhosphoSitePlus; Q8NGP8; -.
DR BioMuta; OR5M1; -.
DR DMDM; 38372744; -.
DR EPD; Q8NGP8; -.
DR MassIVE; Q8NGP8; -.
DR PaxDb; Q8NGP8; -.
DR PRIDE; Q8NGP8; -.
DR Antibodypedia; 58994; 105 antibodies from 21 providers.
DR DNASU; 390168; -.
DR Ensembl; ENST00000641076.1; ENSP00000493124.1; ENSG00000255012.3.
DR GeneID; 390168; -.
DR KEGG; hsa:390168; -.
DR MANE-Select; ENST00000641076.1; ENSP00000493124.1; NM_001004740.2; NP_001004740.1.
DR UCSC; uc001nja.1; human.
DR CTD; 390168; -.
DR DisGeNET; 390168; -.
DR GeneCards; OR5M1; -.
DR HGNC; HGNC:8352; OR5M1.
DR HPA; ENSG00000255012; Not detected.
DR neXtProt; NX_Q8NGP8; -.
DR PharmGKB; PA32546; -.
DR VEuPathDB; HostDB:ENSG00000255012; -.
DR eggNOG; ENOG502TDE6; Eukaryota.
DR GeneTree; ENSGT01050000244907; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGP8; -.
DR OMA; QQMIKRN; -.
DR OrthoDB; 985667at2759; -.
DR PhylomeDB; Q8NGP8; -.
DR TreeFam; TF352751; -.
DR PathwayCommons; Q8NGP8; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390168; 12 hits in 582 CRISPR screens.
DR GeneWiki; OR5M1; -.
DR GenomeRNAi; 390168; -.
DR Pharos; Q8NGP8; Tdark.
DR PRO; PR:Q8NGP8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGP8; protein.
DR ExpressionAtlas; Q8NGP8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 5M1"
FT /id="PRO_0000150604"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 282
FT /note="S -> T (in dbSNP:rs4939078)"
FT /id="VAR_060010"
SQ SEQUENCE 315 AA; 35608 MW; 6EB3D61F84884E56 CRC64;
MFSPNHTIVT EFILLGLTDD PVLEKILFGV FLAIYLITLA GNLCMILLIR TNSHLQTPMY
FFLGHLSFVD ICYSSNVTPN MLHNFLSEQK TISYAGCFTQ CLLFIALVIT EFYILASMAL
DRYVAICSPL HYSSRMSKNI CVCLVTIPYM YGFLSGFSQS LLTFHLSFCG SLEINHFYCA
DPPLIMLACS DTRVKKMAMF VVAGFNLSSS LFIILLSYLF IFAAIFRIRS AEGRHKAFST
CASHLTIVTL FYGTLFCMYV RPPSEKSVEE SKITAVFYTF LSPMLNPLIY SLRNTDVILA
MQQMIRGKSF HKIAV
