OR5M3_HUMAN
ID OR5M3_HUMAN Reviewed; 307 AA.
AC Q8NGP4; B2RNM7; Q6IEW4; Q96RC0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Olfactory receptor 5M3;
DE AltName: Full=Olfactory receptor OR11-191;
GN Name=OR5M3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PHE-84.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5M3";
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DR EMBL; AB065746; BAC05966.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73715.1; -; Genomic_DNA.
DR EMBL; BC136982; AAI36983.1; -; mRNA.
DR EMBL; BC136983; AAI36984.1; -; mRNA.
DR EMBL; AF399518; AAK95003.1; -; Genomic_DNA.
DR EMBL; BK004498; DAA04896.1; -; Genomic_DNA.
DR CCDS; CCDS31532.1; -.
DR RefSeq; NP_001004742.2; NM_001004742.2.
DR AlphaFoldDB; Q8NGP4; -.
DR SMR; Q8NGP4; -.
DR BioGRID; 128545; 12.
DR STRING; 9606.ENSP00000312208; -.
DR GlyGen; Q8NGP4; 1 site.
DR iPTMnet; Q8NGP4; -.
DR PhosphoSitePlus; Q8NGP4; -.
DR BioMuta; OR5M3; -.
DR DMDM; 116242692; -.
DR PaxDb; Q8NGP4; -.
DR PeptideAtlas; Q8NGP4; -.
DR PRIDE; Q8NGP4; -.
DR Antibodypedia; 62745; 40 antibodies from 13 providers.
DR DNASU; 219482; -.
DR Ensembl; ENST00000641993.1; ENSP00000493070.1; ENSG00000174937.5.
DR GeneID; 219482; -.
DR KEGG; hsa:219482; -.
DR MANE-Select; ENST00000641993.1; ENSP00000493070.1; NM_001004742.3; NP_001004742.2.
DR UCSC; uc010rjk.3; human.
DR CTD; 219482; -.
DR GeneCards; OR5M3; -.
DR HGNC; HGNC:14806; OR5M3.
DR HPA; ENSG00000174937; Not detected.
DR neXtProt; NX_Q8NGP4; -.
DR OpenTargets; ENSG00000174937; -.
DR PharmGKB; PA32553; -.
DR VEuPathDB; HostDB:ENSG00000174937; -.
DR eggNOG; ENOG502SJ6M; Eukaryota.
DR GeneTree; ENSGT01050000244860; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGP4; -.
DR OMA; RYMAIGD; -.
DR OrthoDB; 966422at2759; -.
DR PhylomeDB; Q8NGP4; -.
DR TreeFam; TF352751; -.
DR PathwayCommons; Q8NGP4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219482; 11 hits in 638 CRISPR screens.
DR GeneWiki; OR5M3; -.
DR GenomeRNAi; 219482; -.
DR Pharos; Q8NGP4; Tdark.
DR PRO; PR:Q8NGP4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGP4; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..307
FT /note="Olfactory receptor 5M3"
FT /id="PRO_0000150605"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..307
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 84
FT /note="L -> F (in dbSNP:rs605734)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_057549"
FT VARIANT 163
FT /note="G -> S (in dbSNP:rs17150664)"
FT /id="VAR_057550"
SQ SEQUENCE 307 AA; 35156 MW; 2A81FDBC464AEDFA CRC64;
MLNFTDVTEF ILLGLTSRRE WQVLFFIIFL VVYIITMVGN IGMMVLIKVS PQLNNPMYFF
LSHLSFVDVW FSSNVTPKML ENLLSDKKTI TYAGCLVQCF FFIALVHVEI FILAAMAFDR
YMAIGNPLLY GSKMSRVVCI RLITFPYIYG FLTSLAATLW TYGLYFCGKI EINHFYCADP
PLIKMACAGT FVKEYTMIIL AGINFTYSLT VIIISYLFIL IAILRMRSAE GRQKAFSTCG
SHLTAVIIFY GTLIFMYLRR PTEESVEQGK MVAVFYTTVI PMLNPMIYSL RNKDVKKAMM
KVISRSC
