OR5M8_HUMAN
ID OR5M8_HUMAN Reviewed; 311 AA.
AC Q8NGP6; B2RNM5; Q6IEW3; Q96RB8;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Olfactory receptor 5M8;
DE AltName: Full=Olfactory receptor OR11-194;
GN Name=OR5M8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5M8";
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DR EMBL; AB065744; BAC05964.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73716.1; -; Genomic_DNA.
DR EMBL; BC136978; AAI36979.1; -; mRNA.
DR EMBL; BC136980; AAI36981.1; -; mRNA.
DR EMBL; AF399520; AAK95005.1; -; Genomic_DNA.
DR EMBL; BK004499; DAA04897.1; -; Genomic_DNA.
DR CCDS; CCDS31533.1; -.
DR RefSeq; NP_001005282.1; NM_001005282.1.
DR AlphaFoldDB; Q8NGP6; -.
DR SMR; Q8NGP6; -.
DR BioGRID; 128546; 10.
DR STRING; 9606.ENSP00000323354; -.
DR GlyGen; Q8NGP6; 1 site.
DR iPTMnet; Q8NGP6; -.
DR PhosphoSitePlus; Q8NGP6; -.
DR BioMuta; OR5M8; -.
DR DMDM; 38372743; -.
DR MassIVE; Q8NGP6; -.
DR PaxDb; Q8NGP6; -.
DR PRIDE; Q8NGP6; -.
DR ProteomicsDB; 73570; -.
DR Antibodypedia; 66680; 57 antibodies from 13 providers.
DR DNASU; 219484; -.
DR Ensembl; ENST00000327216.5; ENSP00000323354.2; ENSG00000181371.5.
DR GeneID; 219484; -.
DR KEGG; hsa:219484; -.
DR MANE-Select; ENST00000327216.5; ENSP00000323354.2; NM_001005282.1; NP_001005282.1.
DR UCSC; uc001nix.1; human.
DR CTD; 219484; -.
DR GeneCards; OR5M8; -.
DR HGNC; HGNC:14846; OR5M8.
DR HPA; ENSG00000181371; Not detected.
DR neXtProt; NX_Q8NGP6; -.
DR PharmGKB; PA32558; -.
DR VEuPathDB; HostDB:ENSG00000181371; -.
DR eggNOG; ENOG502RTZH; Eukaryota.
DR GeneTree; ENSGT01050000244907; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGP6; -.
DR OMA; TALMETM; -.
DR OrthoDB; 883388at2759; -.
DR PhylomeDB; Q8NGP6; -.
DR TreeFam; TF352751; -.
DR PathwayCommons; Q8NGP6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219484; 6 hits in 663 CRISPR screens.
DR GeneWiki; OR5M8; -.
DR GenomeRNAi; 219484; -.
DR Pharos; Q8NGP6; Tdark.
DR PRO; PR:Q8NGP6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGP6; protein.
DR Bgee; ENSG00000181371; Expressed in anatomical system and 7 other tissues.
DR ExpressionAtlas; Q8NGP6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 5M8"
FT /id="PRO_0000150606"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 311 AA; 35603 MW; 9C7E33E15CC97F59 CRC64;
MRRNCTLVTE FILLGLTSRR ELQILLFTLF LAIYMVTVAG NLGMIVLIQA NAWLHMPMYF
FLSHLSFVDL CFSSNVTPKM LEIFLSEKKS ISYPACLVQC YLFIALVHVE IYILAVMAFD
RYMAICNPLL YGSRMSKSVC SFLITVPYVY GALTGLMETM WTYNLAFCGP NEINHFYCAD
PPLIKLACSD TYNKELSMFI VAGWNLSFSL FIICISYLYI FPAILKIRST EGRQKAFSTC
GSHLTAVTIF YATLFFMYLR PPSKESVEQG KMVAVFYTTV IPMLNLIIYS LRNKNVKEAL
IKELSMKIYF S
