OR5M9_HUMAN
ID OR5M9_HUMAN Reviewed; 310 AA.
AC Q8NGP3; Q6IEW5; Q96RB9;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Olfactory receptor 5M9;
DE AltName: Full=Olfactory receptor OR11-190;
GN Name=OR5M9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5M9";
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DR EMBL; AB065747; BAC05967.1; -; Genomic_DNA.
DR EMBL; AF399519; AAK95004.1; -; Genomic_DNA.
DR EMBL; BK004497; DAA04895.1; -; Genomic_DNA.
DR CCDS; CCDS31531.1; -.
DR RefSeq; NP_001004743.1; NM_001004743.1.
DR AlphaFoldDB; Q8NGP3; -.
DR SMR; Q8NGP3; -.
DR STRING; 9606.ENSP00000279791; -.
DR GlyGen; Q8NGP3; 1 site.
DR iPTMnet; Q8NGP3; -.
DR PhosphoSitePlus; Q8NGP3; -.
DR BioMuta; OR5M9; -.
DR DMDM; 38372741; -.
DR PaxDb; Q8NGP3; -.
DR PeptideAtlas; Q8NGP3; -.
DR PRIDE; Q8NGP3; -.
DR Antibodypedia; 58988; 62 antibodies from 16 providers.
DR DNASU; 390162; -.
DR Ensembl; ENST00000279791.1; ENSP00000279791.1; ENSG00000150269.1.
DR GeneID; 390162; -.
DR KEGG; hsa:390162; -.
DR MANE-Select; ENST00000279791.1; ENSP00000279791.1; NM_001004743.1; NP_001004743.1.
DR UCSC; uc010rjj.2; human.
DR CTD; 390162; -.
DR GeneCards; OR5M9; -.
DR HGNC; HGNC:15294; OR5M9.
DR HPA; ENSG00000150269; Not detected.
DR neXtProt; NX_Q8NGP3; -.
DR PharmGKB; PA32559; -.
DR VEuPathDB; HostDB:ENSG00000150269; -.
DR eggNOG; ENOG502SJ6M; Eukaryota.
DR GeneTree; ENSGT01050000244860; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGP3; -.
DR OrthoDB; 932154at2759; -.
DR PhylomeDB; Q8NGP3; -.
DR TreeFam; TF352751; -.
DR PathwayCommons; Q8NGP3; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390162; 8 hits in 669 CRISPR screens.
DR GeneWiki; OR5M9; -.
DR GenomeRNAi; 390162; -.
DR Pharos; Q8NGP3; Tdark.
DR PRO; PR:Q8NGP3; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGP3; protein.
DR ExpressionAtlas; Q8NGP3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 5M9"
FT /id="PRO_0000150607"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 270
FT /note="K -> R (in dbSNP:rs1945237)"
FT /id="VAR_034230"
SQ SEQUENCE 310 AA; 35093 MW; 6D938CD1D4B7E7D1 CRC64;
MPNFTDVTEF TLLGLTCRQE LQVLFFVVFL AVYMITLLGN IGMIILISIS PQLQSPMYFF
LSHLSFADVC FSSNVTPKML ENLLSETKTI SYVGCLVQCY FFIAVVHVEV YILAVMAFDR
YMAGCNPLLY GSKMSRTVCV RLISVPYVYG FSVSLICTLW TYGLYFCGNF EINHFYCADP
PLIQIACGRV HIKEITMIVI AGINFTYSLS VVLISYTLIV VAVLRMRSAD GRRKAFSTCG
SHLTAVSMFY GTPIFMYLRR PTEESVEQGK MVAVFYTTVI PMLNPMIYSL RNKDVKEAVN
KAITKTYVRQ
