OR5MA_HUMAN
ID OR5MA_HUMAN Reviewed; 315 AA.
AC Q6IEU7; B9EIL9;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Olfactory receptor 5M10;
DE AltName: Full=Olfactory receptor OR11-207;
GN Name=OR5M10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LEU-69.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-69.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5M10";
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DR EMBL; AP002517; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471076; EAW73718.1; -; Genomic_DNA.
DR EMBL; BC140733; AAI40734.1; -; mRNA.
DR EMBL; BK004515; DAA04913.1; -; Genomic_DNA.
DR CCDS; CCDS53630.1; -.
DR RefSeq; NP_001004741.1; NM_001004741.1.
DR AlphaFoldDB; Q6IEU7; -.
DR SMR; Q6IEU7; -.
DR BioGRID; 133429; 1.
DR STRING; 9606.ENSP00000436004; -.
DR GlyGen; Q6IEU7; 1 site.
DR PhosphoSitePlus; Q6IEU7; -.
DR BioMuta; OR5M10; -.
DR DMDM; 74762305; -.
DR MassIVE; Q6IEU7; -.
DR PaxDb; Q6IEU7; -.
DR PeptideAtlas; Q6IEU7; -.
DR PRIDE; Q6IEU7; -.
DR Antibodypedia; 72069; 35 antibodies from 12 providers.
DR DNASU; 390167; -.
DR Ensembl; ENST00000526538.2; ENSP00000435416.2; ENSG00000254834.5.
DR GeneID; 390167; -.
DR KEGG; hsa:390167; -.
DR MANE-Select; ENST00000526538.2; ENSP00000435416.2; NM_001004741.1; NP_001004741.1.
DR UCSC; uc001niz.1; human.
DR CTD; 390167; -.
DR GeneCards; OR5M10; -.
DR HGNC; HGNC:15290; OR5M10.
DR HPA; ENSG00000254834; Not detected.
DR neXtProt; NX_Q6IEU7; -.
DR PharmGKB; PA32547; -.
DR VEuPathDB; HostDB:ENSG00000254834; -.
DR eggNOG; ENOG502TDE6; Eukaryota.
DR GeneTree; ENSGT01050000244907; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q6IEU7; -.
DR OMA; KHVIHAM; -.
DR OrthoDB; 985667at2759; -.
DR PhylomeDB; Q6IEU7; -.
DR TreeFam; TF352751; -.
DR PathwayCommons; Q6IEU7; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390167; 7 hits in 596 CRISPR screens.
DR GeneWiki; OR5M10; -.
DR GenomeRNAi; 390167; -.
DR Pharos; Q6IEU7; Tdark.
DR PRO; PR:Q6IEU7; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6IEU7; protein.
DR ExpressionAtlas; Q6IEU7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 5M10"
FT /id="PRO_0000150608"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 69
FT /note="V -> L (in dbSNP:rs10792043)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_053201"
FT VARIANT 313
FT /note="I -> T (in dbSNP:rs10896488)"
FT /id="VAR_053202"
SQ SEQUENCE 315 AA; 35592 MW; AAB69157FC5682C4 CRC64;
MLSPNHTIVT EFILLGLTDD PVLEKILFGV FLAIYLITLA GNLCMILLIR TNSQLQTPMY
FFLGHLSFVD ICYSSNVTPN MLHNFLSEQK TISYAGCFTQ CLLFIALVIT EFYFLASMAL
DRYVAICSPL HYSSRMSKNI CISLVTVPYM YGFLNGLSQT LLTFHLSFCG SLEINHFYCA
DPPLIMLACS DTRVKKMAMF VVAGFTLSSS LFIILLSYLF IFAAIFRIRS AEGRHKAFST
CASHLTIVTL FYGTLFCMYV RPPSEKSVEE SKIIAVFYTF LSPMLNPLIY SLRNRDVILA
IQQMIRGKSF CKIAV
