OR5MB_HUMAN
ID OR5MB_HUMAN Reviewed; 305 AA.
AC Q96RB7; B2RNL5; B2RNL7;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Olfactory receptor 5M11;
GN Name=OR5M11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASN-171.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-171.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5M11";
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DR EMBL; CH471076; EAW73717.1; -; Genomic_DNA.
DR EMBL; BC136951; AAI36952.1; -; mRNA.
DR EMBL; BC136953; AAI36954.1; -; mRNA.
DR EMBL; AF399521; AAK95006.1; -; Genomic_DNA.
DR CCDS; CCDS53629.1; -.
DR RefSeq; NP_001005245.1; NM_001005245.1.
DR AlphaFoldDB; Q96RB7; -.
DR SMR; Q96RB7; -.
DR BioGRID; 128547; 3.
DR STRING; 9606.ENSP00000432417; -.
DR GlyGen; Q96RB7; 1 site.
DR iPTMnet; Q96RB7; -.
DR PhosphoSitePlus; Q96RB7; -.
DR BioMuta; OR5M11; -.
DR DMDM; 38372852; -.
DR MassIVE; Q96RB7; -.
DR PaxDb; Q96RB7; -.
DR PeptideAtlas; Q96RB7; -.
DR PRIDE; Q96RB7; -.
DR Antibodypedia; 58992; 49 antibodies from 14 providers.
DR DNASU; 219487; -.
DR Ensembl; ENST00000528616.5; ENSP00000432417.2; ENSG00000255223.5.
DR GeneID; 219487; -.
DR KEGG; hsa:219487; -.
DR MANE-Select; ENST00000528616.5; ENSP00000432417.2; NM_001005245.1; NP_001005245.1.
DR UCSC; uc010rjl.2; human.
DR CTD; 219487; -.
DR GeneCards; OR5M11; -.
DR HGNC; HGNC:15291; OR5M11.
DR HPA; ENSG00000255223; Not detected.
DR neXtProt; NX_Q96RB7; -.
DR OpenTargets; ENSG00000255223; -.
DR PharmGKB; PA32548; -.
DR VEuPathDB; HostDB:ENSG00000255223; -.
DR eggNOG; ENOG502T9JC; Eukaryota.
DR GeneTree; ENSGT01050000244907; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q96RB7; -.
DR OMA; ELYMLAA; -.
DR OrthoDB; 968572at2759; -.
DR PhylomeDB; Q96RB7; -.
DR TreeFam; TF352751; -.
DR PathwayCommons; Q96RB7; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219487; 9 hits in 672 CRISPR screens.
DR GeneWiki; OR5M11; -.
DR GenomeRNAi; 219487; -.
DR Pharos; Q96RB7; Tdark.
DR PRO; PR:Q96RB7; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96RB7; protein.
DR Bgee; ENSG00000255223; Expressed in urinary bladder and 1 other tissue.
DR ExpressionAtlas; Q96RB7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..305
FT /note="Olfactory receptor 5M11"
FT /id="PRO_0000150609"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 171
FT /note="S -> N (in dbSNP:rs628524)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_034231"
FT VARIANT 280
FT /note="V -> L (in dbSNP:rs17547207)"
FT /id="VAR_034232"
SQ SEQUENCE 305 AA; 34450 MW; C846F0070FD9FF0E CRC64;
MSNTNGSAIT EFILLGLTDC PELQSLLFVL FLVVYLVTLL GNLGMIMLMR LDSRLHTPMY
FFLTNLAFVD LCYTSNATPQ MSTNIVSEKT ISFAGCFTQC YIFIALLLTE FYMLAAMAYD
RYVAIYDPLR YSVKTSRRVC ICLATFPYVY GFSDGLFQAI LTFRLTFCRS SVINHFYCAD
PPLIKLSCSD TYVKEHAMFI SAGFNLSSSL TIVLVSYAFI LAAILRIKSA EGRHKAFSTC
GSHMMAVTLF YGTLFCMYIR PPTDKTVEES KIIAVFYTFV SPVLNPLIYS LRNKDVKQAL
KNVLR
