ID   OR5P2_HUMAN             Reviewed;         322 AA.
AC   Q8WZ92; Q3MIS8;
DT   10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Olfactory receptor 5P2;
DE   AltName: Full=Olfactory receptor-like protein JCG3;
GN   Name=OR5P2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Tongue;
RX   PubMed=11705801; DOI=10.1093/chemse/26.9.1157;
RA   Gaudin J.-C., Breuils L., Haertle T.;
RT   "New GPCRs from a human lingual cDNA library.";
RL   Chem. Senses 26:1157-1166(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Odorant receptor (Potential). May be involved in taste
CC       perception. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in the tongue.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5P2";
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DR   EMBL; AF173006; AAL32992.1; -; mRNA.
DR   EMBL; AB065767; BAC05987.1; -; Genomic_DNA.
DR   EMBL; BC101710; AAI01711.1; -; mRNA.
DR   EMBL; BC113557; AAI13558.1; -; mRNA.
DR   CCDS; CCDS7782.1; -.
DR   RefSeq; NP_703145.1; NM_153444.1.
DR   AlphaFoldDB; Q8WZ92; -.
DR   SMR; Q8WZ92; -.
DR   STRING; 9606.ENSP00000331823; -.
DR   GlyGen; Q8WZ92; 2 sites.
DR   BioMuta; OR5P2; -.
DR   DMDM; 20532190; -.
DR   MassIVE; Q8WZ92; -.
DR   PaxDb; Q8WZ92; -.
DR   PRIDE; Q8WZ92; -.
DR   Antibodypedia; 57622; 53 antibodies from 15 providers.
DR   DNASU; 120065; -.
DR   Ensembl; ENST00000329434.3; ENSP00000331823.2; ENSG00000183303.3.
DR   Ensembl; ENST00000611603.2; ENSP00000480613.1; ENSG00000276025.2.
DR   Ensembl; ENST00000625920.1; ENSP00000486671.1; ENSG00000280931.1.
DR   GeneID; 120065; -.
DR   KEGG; hsa:120065; -.
DR   MANE-Select; ENST00000329434.3; ENSP00000331823.2; NM_153444.1; NP_703145.1.
DR   UCSC; uc001mfp.2; human.
DR   CTD; 120065; -.
DR   GeneCards; OR5P2; -.
DR   HGNC; HGNC:14783; OR5P2.
DR   HPA; ENSG00000183303; Not detected.
DR   neXtProt; NX_Q8WZ92; -.
DR   OpenTargets; ENSG00000183303; -.
DR   PharmGKB; PA32561; -.
DR   VEuPathDB; HostDB:ENSG00000183303; -.
DR   eggNOG; ENOG502SKA1; Eukaryota.
DR   GeneTree; ENSGT01050000244860; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8WZ92; -.
DR   OMA; CIYLVTT; -.
DR   OrthoDB; 999769at2759; -.
DR   PhylomeDB; Q8WZ92; -.
DR   TreeFam; TF338848; -.
DR   PathwayCommons; Q8WZ92; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 120065; 8 hits in 640 CRISPR screens.
DR   GeneWiki; OR5P2; -.
DR   GenomeRNAi; 120065; -.
DR   Pharos; Q8WZ92; Tdark.
DR   PRO; PR:Q8WZ92; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8WZ92; protein.
DR   Bgee; ENSG00000183303; Expressed in skin of abdomen and 6 other tissues.
DR   ExpressionAtlas; Q8WZ92; baseline and differential.
DR   Genevisible; Q8WZ92; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..322
FT                   /note="Olfactory receptor 5P2"
FT                   /id="PRO_0000150610"
FT   TOPO_DOM        1..28
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..42
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        43..50
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        72..95
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        117..135
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..192
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..213
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        214..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        255..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        289..322
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        8
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        259
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        93..185
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         7
FT                   /note="G -> R (in dbSNP:rs1482804)"
FT                   /id="VAR_053203"
FT   VARIANT         318
FT                   /note="N -> D (in dbSNP:rs7949771)"
FT                   /id="VAR_053204"
SQ   SEQUENCE   322 AA;  35786 MW;  0D4F4FBD4FD00FEC CRC64;
     MNSLKDGNHT ALTGFILLGL TDDPILRVIL FMIILSGNLS IIILIRISSQ LHHPMYFFLS
     HLAFADMAYS SSVTPNMLVN FLVERNTVSY LGCAIQLGSA AFFATVECVL LAAMAYDRFV
     AICSPLLYST KMSTQVSVQL LLVVYIAGFL IAVSYTTSFY FLLFCGPNQV NHFFCDFAPL
     LELSCSDISV STVVLSFSSG SIIVVTVCVI AVCYIYILIT ILKMRSTEGH HKAFSTCTSH
     LTVVTLFYGT ITFIYVMPNF SYSTDQNKVV SVLYTVVIPM LNPLIYSLRN KEIKGALKRE
     LVRKILSHDA CYFSRTSNND IT