OR5P3_HUMAN
ID OR5P3_HUMAN Reviewed; 311 AA.
AC Q8WZ94; Q6IFE1; Q8NGM2;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Olfactory receptor 5P3;
DE AltName: Full=Olfactory receptor OR11-94;
DE AltName: Full=Olfactory receptor-like protein JCG1;
GN Name=OR5P3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Tongue;
RX PubMed=11705801; DOI=10.1093/chemse/26.9.1157;
RA Gaudin J.-C., Breuils L., Haertle T.;
RT "New GPCRs from a human lingual cDNA library.";
RL Chem. Senses 26:1157-1166(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor (Potential). May be involved in taste
CC perception. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in the tongue.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05990.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5P3";
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DR EMBL; AF158377; AAL32991.1; -; mRNA.
DR EMBL; AB065770; BAC05990.1; ALT_INIT; Genomic_DNA.
DR EMBL; CH471064; EAW68645.1; -; Genomic_DNA.
DR EMBL; BK004321; DAA04719.1; -; Genomic_DNA.
DR CCDS; CCDS7783.1; -.
DR RefSeq; NP_703146.1; NM_153445.1.
DR AlphaFoldDB; Q8WZ94; -.
DR SMR; Q8WZ94; -.
DR STRING; 9606.ENSP00000332068; -.
DR GlyGen; Q8WZ94; 1 site.
DR BioMuta; OR5P3; -.
DR DMDM; 20532191; -.
DR MassIVE; Q8WZ94; -.
DR PaxDb; Q8WZ94; -.
DR PeptideAtlas; Q8WZ94; -.
DR PRIDE; Q8WZ94; -.
DR Antibodypedia; 57623; 106 antibodies from 19 providers.
DR DNASU; 120066; -.
DR Ensembl; ENST00000619725.1; ENSP00000482237.1; ENSG00000278253.1.
DR Ensembl; ENST00000630502.1; ENSP00000486070.1; ENSG00000280808.2.
DR Ensembl; ENST00000641167.1; ENSP00000492944.1; ENSG00000182334.3.
DR Ensembl; ENST00000641500.1; ENSP00000493390.1; ENSG00000280808.2.
DR GeneID; 120066; -.
DR KEGG; hsa:120066; -.
DR MANE-Select; ENST00000641167.1; ENSP00000492944.1; NM_153445.2; NP_703146.1.
DR UCSC; uc010rbg.2; human.
DR CTD; 120066; -.
DR GeneCards; OR5P3; -.
DR HGNC; HGNC:14784; OR5P3.
DR HPA; ENSG00000182334; Not detected.
DR neXtProt; NX_Q8WZ94; -.
DR OpenTargets; ENSG00000182334; -.
DR PharmGKB; PA32562; -.
DR VEuPathDB; HostDB:ENSG00000182334; -.
DR eggNOG; ENOG502SKA1; Eukaryota.
DR GeneTree; ENSGT01050000244860; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8WZ94; -.
DR OMA; LACSHDF; -.
DR OrthoDB; 1002838at2759; -.
DR PhylomeDB; Q8WZ94; -.
DR TreeFam; TF338848; -.
DR PathwayCommons; Q8WZ94; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 120066; 8 hits in 669 CRISPR screens.
DR GeneWiki; OR5P3; -.
DR GenomeRNAi; 120066; -.
DR Pharos; Q8WZ94; Tdark.
DR PRO; PR:Q8WZ94; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8WZ94; protein.
DR Bgee; ENSG00000182334; Expressed in skin of abdomen and 3 other tissues.
DR ExpressionAtlas; Q8WZ94; baseline and differential.
DR Genevisible; Q8WZ94; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 5P3"
FT /id="PRO_0000150611"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 158
FT /note="T -> K (in dbSNP:rs16932503)"
FT /id="VAR_048048"
FT VARIANT 251
FT /note="F -> L (in dbSNP:rs364427)"
FT /id="VAR_048094"
SQ SEQUENCE 311 AA; 34296 MW; D6E37E03C317DAA3 CRC64;
MGTGNDTTVV EFTLLGLSED TTVCAILFLV FLGIYVVTLM GNISIIVLIR RSHHLHTPMY
IFLCHLAFVD IGYSSSVTPV MLMSFLRKET SLPVAGCVAQ LCSVVTFGTA ECFLLAAMAY
DRYVAICSPL LYSTCMSPGV CIILVGMSYL GGCVNAWTFI GCLLRLSFCG PNKVNHFFCD
YSPLLKLACS HDFTFEIIPA ISSGSIIVAT VCVIAISYIY ILITILKMHS TKGRHKAFST
CTSHLTAVTL FYGTITFIYV MPKSSYSTDQ NKVVSVFYTV VIPMLNPLIY SLRNKEIKGA
LKRELRIKIF S
