OR5R1_HUMAN
ID OR5R1_HUMAN Reviewed; 324 AA.
AC Q8NH85;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Olfactory receptor 8U3 {ECO:0000312|HGNC:HGNC:14841};
DE AltName: Full=Olfactory receptor 5R1;
DE AltName: Full=Olfactory receptor OR11-185;
GN Name=OR8U3 {ECO:0000312|HGNC:HGNC:14841}; Synonyms=OR5R1, OR5R1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5R1";
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DR EMBL; AB065504; BAC05752.1; -; Genomic_DNA.
DR EMBL; BK004514; DAA04912.1; -; Genomic_DNA.
DR RefSeq; NP_001004744.1; NM_001004744.1.
DR AlphaFoldDB; Q8NH85; -.
DR SMR; Q8NH85; -.
DR STRING; 9606.ENSP00000308595; -.
DR GlyGen; Q8NH85; 1 site.
DR iPTMnet; Q8NH85; -.
DR PhosphoSitePlus; Q8NH85; -.
DR BioMuta; OR5R1; -.
DR DMDM; 60392877; -.
DR MassIVE; Q8NH85; -.
DR PaxDb; Q8NH85; -.
DR PeptideAtlas; Q8NH85; -.
DR PRIDE; Q8NH85; -.
DR Antibodypedia; 78740; 38 antibodies from 17 providers.
DR DNASU; 219479; -.
DR Ensembl; ENST00000623286.1; ENSP00000485324.1; ENSG00000279961.2.
DR GeneID; 219479; -.
DR KEGG; hsa:219479; -.
DR MANE-Select; ENST00000623286.1; ENSP00000485324.1; NM_001004744.1; NP_001004744.1.
DR UCSC; uc010rji.2; human.
DR CTD; 219479; -.
DR GeneCards; OR8U3; -.
DR HGNC; HGNC:14841; OR8U3.
DR HPA; ENSG00000279961; Not detected.
DR neXtProt; NX_Q8NH85; -.
DR OpenTargets; ENSG00000279961; -.
DR VEuPathDB; HostDB:ENSG00000279961; -.
DR eggNOG; ENOG502RF3K; Eukaryota.
DR GeneTree; ENSGT00950000182718; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NH85; -.
DR OMA; PELQVPC; -.
DR OrthoDB; 1031063at2759; -.
DR PhylomeDB; Q8NH85; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NH85; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NH85; -.
DR BioGRID-ORCS; 219479; 9 hits in 665 CRISPR screens.
DR GeneWiki; OR5R1; -.
DR GenomeRNAi; 219479; -.
DR Pharos; Q8NH85; Tdark.
DR PRO; PR:Q8NH85; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH85; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..324
FT /note="Olfactory receptor 8U3"
FT /id="PRO_0000150612"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 7
FT /note="I -> T (in dbSNP:rs7931261)"
FT /id="VAR_024102"
FT VARIANT 103
FT /note="C -> Y (in dbSNP:rs7123108)"
FT /id="VAR_053205"
FT VARIANT 121
FT /note="D -> G (in dbSNP:rs7111634)"
FT /id="VAR_053206"
FT VARIANT 122
FT /note="C -> R (in dbSNP:rs6591324)"
FT /id="VAR_024103"
FT VARIANT 128
FT /note="S -> G (in dbSNP:rs7933772)"
FT /id="VAR_053207"
FT VARIANT 132
FT /note="Y -> H (in dbSNP:rs17150578)"
FT /id="VAR_053208"
FT VARIANT 162
FT /note="I -> T (in dbSNP:rs12785840)"
FT /id="VAR_053209"
FT VARIANT 184
FT /note="F -> L (in dbSNP:rs7930678)"
FT /id="VAR_024104"
FT VARIANT 274
FT /note="A -> V (in dbSNP:rs998544)"
FT /id="VAR_024105"
SQ SEQUENCE 324 AA; 36708 MW; C26CCA953E8846FE CRC64;
MAEVNIIYVT VFILKGITNR PELQAPCFGV FLVIYLVTVL GNLGLITLIK IDTRLHTPMY
YFLSHLAFVD LCYSSAITPK MMVNFVVERN TIPFHACATQ LGCFLTFMIT ECFLLASMAY
DCYVAICSPL HYSTLMSRRV CIQLVAVPYI YSFLVALFHT VITFRLTYCG PNLINHFYCD
DLPFLALSCS DTHMKEILIF AFAGFDMISS SSIVLTSYIF IIAAILRIRS TQGQHKAIST
CGSHMVTVTI FYGTLIFMYL QPKSNHSLDT DKMASVFYTV VIPMLNPLIY SLRNKEVKDA
SKKALDKGCE NLQILTFLKI RKLY
