OR5T1_HUMAN
ID OR5T1_HUMAN Reviewed; 326 AA.
AC Q8NG75; B2RNM9;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 5T1;
DE AltName: Full=Olfactory receptor OR11-179;
GN Name=OR5T1; Synonyms=OR5T1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5T1";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065962; BAC06174.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73706.1; -; Genomic_DNA.
DR EMBL; BC136992; AAI36993.1; -; mRNA.
DR EMBL; BC136993; AAI36994.1; -; mRNA.
DR EMBL; BK004336; DAA04734.1; -; Genomic_DNA.
DR CCDS; CCDS31525.1; -.
DR RefSeq; NP_001004745.1; NM_001004745.1.
DR AlphaFoldDB; Q8NG75; -.
DR SMR; Q8NG75; -.
DR BioGRID; 133424; 3.
DR STRING; 9606.ENSP00000323612; -.
DR GlyGen; Q8NG75; 2 sites.
DR iPTMnet; Q8NG75; -.
DR PhosphoSitePlus; Q8NG75; -.
DR BioMuta; OR5T1; -.
DR DMDM; 71153031; -.
DR MassIVE; Q8NG75; -.
DR PaxDb; Q8NG75; -.
DR PeptideAtlas; Q8NG75; -.
DR PRIDE; Q8NG75; -.
DR Antibodypedia; 62740; 24 antibodies from 13 providers.
DR DNASU; 390155; -.
DR Ensembl; ENST00000576733.2; ENSP00000459132.1; ENSG00000262784.2.
DR Ensembl; ENST00000641665.1; ENSP00000493364.1; ENSG00000181698.5.
DR GeneID; 390155; -.
DR KEGG; hsa:390155; -.
DR MANE-Select; ENST00000641665.1; ENSP00000493364.1; NM_001004745.2; NP_001004745.1.
DR UCSC; uc001nio.1; human.
DR CTD; 390155; -.
DR GeneCards; OR5T1; -.
DR HGNC; HGNC:14821; OR5T1.
DR HPA; ENSG00000181698; Not detected.
DR neXtProt; NX_Q8NG75; -.
DR PharmGKB; PA32566; -.
DR VEuPathDB; HostDB:ENSG00000181698; -.
DR eggNOG; ENOG502SHA3; Eukaryota.
DR GeneTree; ENSGT00940000153301; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NG75; -.
DR OMA; FTERNWF; -.
DR OrthoDB; 960379at2759; -.
DR PhylomeDB; Q8NG75; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NG75; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390155; 13 hits in 606 CRISPR screens.
DR GeneWiki; OR5T1; -.
DR GenomeRNAi; 390155; -.
DR Pharos; Q8NG75; Tdark.
DR PRO; PR:Q8NG75; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NG75; protein.
DR ExpressionAtlas; Q8NG75; baseline and differential.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..326
FT /note="Olfactory receptor 5T1"
FT /id="PRO_0000150613"
FT TOPO_DOM 1..37
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..66
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..111
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 133..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..208
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..283
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..326
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 60
FT /note="P -> L (in dbSNP:rs7126079)"
FT /id="VAR_053210"
FT VARIANT 164
FT /note="S -> G (in dbSNP:rs12360890)"
FT /id="VAR_034233"
SQ SEQUENCE 326 AA; 36885 MW; FE6C8ED733E18E97 CRC64;
MSGLPSDMDL YKLQLNNFTE VTMFILISFT EEFDVQVFLF LLFLAIYLFT LIGNLGLVVP
IIGDFWLHSP MYYFLGVLSF LDVCYSTVVT PKMLVNFLAK NKSISFLGCA TQMFLACTFG
TTECFLLAAM AYDRYVAIYN PLLYSVSMSP RVYVPLITAS YVASILHATI HTVATFSLSF
CGSNEIRHVF CNMPPLLAIS CSDTHVIQLL FFYFVGSIEI VTILIVLISY GFILLAILKM
QSAEGRRKVF STCGAHLTGV TIYHGTILFM YVRPSSSYTS DNDMIVSIFY TIVIPMLNPI
IYSLRNKDVK EAIKRLLVRN WFINKL
