OR5T2_HUMAN
ID OR5T2_HUMAN Reviewed; 359 AA.
AC Q8NGG2; B9EGX5; Q6IFC8;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 3.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Olfactory receptor 5T2;
DE AltName: Full=Olfactory receptor OR11-177;
GN Name=OR5T2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-87.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-31 is the initiator.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5T2";
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DR EMBL; AB065838; BAC06057.1; -; Genomic_DNA.
DR EMBL; AC022882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136876; AAI36877.1; -; mRNA.
DR EMBL; BK004334; DAA04732.1; -; Genomic_DNA.
DR RefSeq; NP_001004746.1; NM_001004746.1.
DR AlphaFoldDB; Q8NGG2; -.
DR SMR; Q8NGG2; -.
DR STRING; 9606.ENSP00000323688; -.
DR GlyGen; Q8NGG2; 1 site.
DR iPTMnet; Q8NGG2; -.
DR PhosphoSitePlus; Q8NGG2; -.
DR BioMuta; OR5T2; -.
DR DMDM; 223590250; -.
DR PaxDb; Q8NGG2; -.
DR PeptideAtlas; Q8NGG2; -.
DR PRIDE; Q8NGG2; -.
DR Antibodypedia; 27221; 40 antibodies from 11 providers.
DR DNASU; 219464; -.
DR Ensembl; ENST00000573647.2; ENSP00000460931.1; ENSG00000262851.2.
DR GeneID; 219464; -.
DR KEGG; hsa:219464; -.
DR UCSC; uc010rjc.2; human.
DR CTD; 219464; -.
DR GeneCards; OR5T2; -.
DR HGNC; HGNC:15296; OR5T2.
DR HPA; ENSG00000181718; Not detected.
DR neXtProt; NX_Q8NGG2; -.
DR PharmGKB; PA32567; -.
DR VEuPathDB; HostDB:ENSG00000181718; -.
DR eggNOG; ENOG502SHA3; Eukaryota.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGG2; -.
DR OrthoDB; 960379at2759; -.
DR PhylomeDB; Q8NGG2; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGG2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219464; 10 hits in 667 CRISPR screens.
DR GeneWiki; OR5T2; -.
DR GenomeRNAi; 219464; -.
DR Pharos; Q8NGG2; Tdark.
DR PRO; PR:Q8NGG2; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8NGG2; protein.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..359
FT /note="Olfactory receptor 5T2"
FT /id="PRO_0000150614"
FT TOPO_DOM 1..64
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 86..93
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..138
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..178
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..235
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..276
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..310
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 332..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 21
FT /note="S -> Y (in dbSNP:rs3919907)"
FT /id="VAR_054349"
FT VARIANT 64
FT /note="T -> I (in dbSNP:rs11227599)"
FT /id="VAR_054350"
FT VARIANT 87
FT /note="V -> L (in dbSNP:rs10791893)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_054351"
FT VARIANT 125
FT /note="T -> M (in dbSNP:rs7122514)"
FT /id="VAR_054352"
FT VARIANT 238
FT /note="L -> V (in dbSNP:rs12221615)"
FT /id="VAR_054353"
FT VARIANT 309
FT /note="H -> D (in dbSNP:rs7121880)"
FT /id="VAR_054354"
SQ SEQUENCE 359 AA; 40696 MW; 5A89383A21841F73 CRC64;
MSYSIYKSTV NIPLSHGVVH SFCHNMNCNF MHIFKFVLDF NMKNVTEVTL FVLKGFTDNL
ELQTIFFFLF LAIYLFTLMG NLGLILVVIR DSQLHKPMYY FLSMLSSVDA CYSSVITPNM
LVDFTTKNKV ISFLGCVAQV FLACSFGTTE CFLLAAMAYD RYVAIYNPLL YSVSMSPRVY
MPLINASYVA GILHATIHTV ATFSLSFCGA NEIRRVFCDI PPLLAISYSD THTNQLLLFY
FVGSIELVTI LIVLISYGLI LLAILKMYSA EGRRKVFSTC GAHLTGVSIY YGTILFMYVR
PSSSYASDHD MIVSIFYTIV IPLLNPVIYS LRNKDVKDSM KKMFGKNQVI NKVYFHTKK
