OR5T3_HUMAN
ID OR5T3_HUMAN Reviewed; 340 AA.
AC Q8NGG3; Q6IFC7;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 3.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Olfactory receptor 5T3;
DE AltName: Full=Olfactory receptor OR11-178;
GN Name=OR5T3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-19 is the initiator.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5T3";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065837; BAC06056.1; -; Genomic_DNA.
DR EMBL; AC022882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471076; EAW73705.1; -; Genomic_DNA.
DR EMBL; BK004335; DAA04733.1; -; Genomic_DNA.
DR RefSeq; NP_001004747.1; NM_001004747.1.
DR AlphaFoldDB; Q8NGG3; -.
DR SMR; Q8NGG3; -.
DR IntAct; Q8NGG3; 1.
DR STRING; 9606.ENSP00000305403; -.
DR GlyGen; Q8NGG3; 2 sites.
DR iPTMnet; Q8NGG3; -.
DR PhosphoSitePlus; Q8NGG3; -.
DR BioMuta; OR5T3; -.
DR DMDM; 218512125; -.
DR MassIVE; Q8NGG3; -.
DR PaxDb; Q8NGG3; -.
DR PeptideAtlas; Q8NGG3; -.
DR PRIDE; Q8NGG3; -.
DR ProteomicsDB; 73505; -.
DR DNASU; 390154; -.
DR Ensembl; ENST00000575738.1; ENSP00000459586.1; ENSG00000261897.1.
DR GeneID; 390154; -.
DR KEGG; hsa:390154; -.
DR UCSC; uc010rjd.2; human.
DR CTD; 390154; -.
DR GeneCards; OR5T3; -.
DR HGNC; HGNC:15297; OR5T3.
DR neXtProt; NX_Q8NGG3; -.
DR PharmGKB; PA32568; -.
DR eggNOG; ENOG502SHA3; Eukaryota.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGG3; -.
DR OrthoDB; 960379at2759; -.
DR PhylomeDB; Q8NGG3; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGG3; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390154; 8 hits in 624 CRISPR screens.
DR GeneWiki; OR5T3; -.
DR GenomeRNAi; 390154; -.
DR Pharos; Q8NGG3; Tdark.
DR PRO; PR:Q8NGG3; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8NGG3; protein.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..340
FT /note="Olfactory receptor 5T3"
FT /id="PRO_0000150615"
FT TOPO_DOM 1..55
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..129
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..226
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..267
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..301
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..340
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 35
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 119
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 127..219
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 84
FT /note="W -> G (in dbSNP:rs17150243)"
FT /id="VAR_047836"
SQ SEQUENCE 340 AA; 38346 MW; C2CD1CC3A28FB246 CRC64;
MDSTFTGYNL YNLQVKTEMD KLSSGLDIYR NPLKNKTEVT MFILTGFTDD FELQVFLFLL
FFAIYLFTLI GNLGLVVLVI EDSWLHNPMY YFLSVLSFLD ACYSTVVTPK MLVNFLAKNK
SISFIGCATQ MLLFVTFGTT ECFLLAAMAY DHYVAIYNPL LYSVSMSPRV YVPLITASYV
AGILHATIHI VATFSLSFCG SNEIRHVFCD MPPLLAISCS DTHTNQLLLF YFVGSIEIVT
ILIVLISCDF ILLSILKMHS AKGRQKAFST CGSHLTGVTI YHGTILVSYM RPSSSYASDH
DIIVSIFYTI VIPKLNPIIY SLRNKEVKKA VKKMLKLVYK
