OR5V1_HUMAN
ID OR5V1_HUMAN Reviewed; 321 AA.
AC Q9UGF6; A2BDZ0; B0S860; Q5SQI9; Q6NTB5; Q8IVL3;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Olfactory receptor 5V1;
DE AltName: Full=Hs6M1-21;
DE AltName: Full=Olfactory receptor OR6-26;
GN Name=OR5V1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Testis;
RX PubMed=12637542; DOI=10.1074/jbc.m212424200;
RA Volz A., Ehlers A., Younger R., Forbes S., Trowsdale J., Schnorr D.,
RA Beck S., Ziegler A.;
RT "Complex transcription and splicing of odorant receptor genes.";
RL J. Biol. Chem. 278:19691-19701(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS TRP-23 AND
RP MET-45.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT TRP-23.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [7]
RP VARIANT PRO-136.
RX PubMed=21248752; DOI=10.1038/nature09639;
RA Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H.,
RA Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J.,
RA Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M.,
RA Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L.,
RA Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J.,
RA Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A.,
RA Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K.,
RA Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.;
RT "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene
RT PBRM1 in renal carcinoma.";
RL Nature 469:539-542(2011).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5V1";
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DR EMBL; AJ459859; CAD31042.1; -; mRNA.
DR EMBL; BX005133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL096770; CAB65797.1; -; Genomic_DNA.
DR EMBL; AL732432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03189.1; -; Genomic_DNA.
DR EMBL; BC069149; AAH69149.1; -; mRNA.
DR EMBL; BK004440; DAA04838.1; -; Genomic_DNA.
DR CCDS; CCDS4657.1; -.
DR RefSeq; NP_110503.3; NM_030876.5.
DR RefSeq; XP_011513231.1; XM_011514929.2.
DR RefSeq; XP_011513232.1; XM_011514930.2.
DR AlphaFoldDB; Q9UGF6; -.
DR SMR; Q9UGF6; -.
DR STRING; 9606.ENSP00000366359; -.
DR GlyGen; Q9UGF6; 1 site.
DR iPTMnet; Q9UGF6; -.
DR PhosphoSitePlus; Q9UGF6; -.
DR BioMuta; OR5V1; -.
DR DMDM; 14423825; -.
DR PaxDb; Q9UGF6; -.
DR PeptideAtlas; Q9UGF6; -.
DR PRIDE; Q9UGF6; -.
DR Antibodypedia; 54815; 79 antibodies from 22 providers.
DR DNASU; 81696; -.
DR Ensembl; ENST00000230223.5; ENSP00000230223.5; ENSG00000112461.9.
DR Ensembl; ENST00000377154.1; ENSP00000366359.1; ENSG00000243729.5.
DR Ensembl; ENST00000400698.6; ENSP00000383534.2; ENSG00000112461.9.
DR Ensembl; ENST00000418692.1; ENSP00000415545.1; ENSG00000227137.8.
DR Ensembl; ENST00000421859.5; ENSP00000412591.1; ENSG00000227137.8.
DR Ensembl; ENST00000441440.5; ENSP00000404163.1; ENSG00000233046.8.
DR Ensembl; ENST00000444009.5; ENSP00000407363.1; ENSG00000243441.6.
DR Ensembl; ENST00000446761.1; ENSP00000404109.1; ENSG00000233046.8.
DR Ensembl; ENST00000458372.1; ENSP00000404990.1; ENSG00000243441.6.
DR Ensembl; ENST00000548546.1; ENSP00000449041.1; ENSG00000227137.8.
DR Ensembl; ENST00000549299.1; ENSP00000450230.1; ENSG00000233046.8.
DR Ensembl; ENST00000550240.1; ENSP00000446579.1; ENSG00000243441.6.
DR Ensembl; ENST00000641768.1; ENSP00000493269.1; ENSG00000243729.5.
DR GeneID; 81696; -.
DR KEGG; hsa:81696; -.
DR MANE-Select; ENST00000641768.1; ENSP00000493269.1; NM_030876.6; NP_110503.3.
DR UCSC; uc011dlo.2; human.
DR CTD; 81696; -.
DR DisGeNET; 81696; -.
DR GeneCards; OR5V1; -.
DR HGNC; HGNC:13972; OR5V1.
DR HPA; ENSG00000243729; Not detected.
DR neXtProt; NX_Q9UGF6; -.
DR OpenTargets; ENSG00000243729; -.
DR PharmGKB; PA32570; -.
DR VEuPathDB; HostDB:ENSG00000243729; -.
DR eggNOG; ENOG502QWPY; Eukaryota.
DR GeneTree; ENSGT01050000244853; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q9UGF6; -.
DR OMA; FFLTYVC; -.
DR OrthoDB; 950898at2759; -.
DR PhylomeDB; Q9UGF6; -.
DR TreeFam; TF352732; -.
DR PathwayCommons; Q9UGF6; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 81696; 7 hits in 654 CRISPR screens.
DR GeneWiki; OR5V1; -.
DR GenomeRNAi; 81696; -.
DR Pharos; Q9UGF6; Tdark.
DR PRO; PR:Q9UGF6; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q9UGF6; protein.
DR ExpressionAtlas; Q9UGF6; baseline and differential.
DR Genevisible; Q9UGF6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..321
FT /note="Olfactory receptor 5V1"
FT /id="PRO_0000150617"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..321
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 23
FT /note="L -> W (in dbSNP:rs6930033)"
FT /evidence="ECO:0000269|PubMed:14574404,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_053211"
FT VARIANT 45
FT /note="I -> M (in dbSNP:rs9257770)"
FT /evidence="ECO:0000269|PubMed:14574404"
FT /id="VAR_053212"
FT VARIANT 136
FT /note="L -> P (found in a renal cell carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:21248752"
FT /id="VAR_064740"
FT CONFLICT 112
FT /note="C -> R (in Ref. 1; CAD31042)"
FT /evidence="ECO:0000305"
FT CONFLICT 116
FT /note="A -> T (in Ref. 1; CAD31042)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 321 AA; 36057 MW; AAC426FDCF58E375 CRC64;
MERKNQTAIT EFIILGFSNL NELQFLLFTI FFLTYFCTLG GNILIILTTV TDPHLHTPMY
YFLGNLAFID ICYTTSNVPQ MMVHLLSKKK SISYVGCVVQ LFAFVFFVGS ECLLLAAMAY
DRYIAICNPL RYSVILSKVL CNQLAASCWA AGFLNSVVHT VLTFCLPFCG NNQINYFFCD
IPPLLILSCG NTSVNELALL STGVFIGWTP FLCIVLSYIC IISTILRIQS SEGRRKAFST
CASHLAIVFL FYGSAIFTYV RPISTYSLKK DRLVSVLYSV VTPMLNPIIY TLRNKDIKEA
VKTIGSKWQP PISSLDSKLT Y
