OR5W2_HUMAN
ID OR5W2_HUMAN Reviewed; 310 AA.
AC Q8NH69;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Olfactory receptor 5W2;
DE AltName: Full=Olfactory receptor 5W3;
DE AltName: Full=Olfactory receptor OR11-155;
GN Name=OR5W2; Synonyms=OR5W2P, OR5W3P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5W2";
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DR EMBL; AB065520; BAC05768.1; -; Genomic_DNA.
DR EMBL; BK004398; DAA04796.1; -; Genomic_DNA.
DR CCDS; CCDS31513.1; -.
DR RefSeq; NP_001001960.1; NM_001001960.1.
DR AlphaFoldDB; Q8NH69; -.
DR SMR; Q8NH69; -.
DR STRING; 9606.ENSP00000342448; -.
DR GlyGen; Q8NH69; 1 site.
DR BioMuta; OR5W2; -.
DR DMDM; 74762590; -.
DR MassIVE; Q8NH69; -.
DR PaxDb; Q8NH69; -.
DR PeptideAtlas; Q8NH69; -.
DR PRIDE; Q8NH69; -.
DR Antibodypedia; 58948; 99 antibodies from 20 providers.
DR DNASU; 390148; -.
DR Ensembl; ENST00000344514.1; ENSP00000342448.1; ENSG00000187612.1.
DR GeneID; 390148; -.
DR KEGG; hsa:390148; -.
DR MANE-Select; ENST00000344514.1; ENSP00000342448.1; NM_001001960.1; NP_001001960.1.
DR UCSC; uc010rir.2; human.
DR CTD; 390148; -.
DR DisGeNET; 390148; -.
DR GeneCards; OR5W2; -.
DR HGNC; HGNC:15299; OR5W2.
DR HPA; ENSG00000187612; Not detected.
DR neXtProt; NX_Q8NH69; -.
DR PharmGKB; PA32572; -.
DR VEuPathDB; HostDB:ENSG00000187612; -.
DR eggNOG; ENOG502RF13; Eukaryota.
DR GeneTree; ENSGT01050000244804; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NH69; -.
DR OMA; VLIRMDY; -.
DR OrthoDB; 966398at2759; -.
DR PhylomeDB; Q8NH69; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NH69; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390148; 8 hits in 670 CRISPR screens.
DR GeneWiki; OR5W2; -.
DR GenomeRNAi; 390148; -.
DR Pharos; Q8NH69; Tdark.
DR PRO; PR:Q8NH69; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH69; protein.
DR Bgee; ENSG00000187612; Expressed in colonic epithelium and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 5W2"
FT /id="PRO_0000150618"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 39
FT /note="F -> L (in dbSNP:rs17511797)"
FT /id="VAR_053213"
FT VARIANT 65
FT /note="H -> R (in dbSNP:rs12419022)"
FT /id="VAR_053214"
FT VARIANT 160
FT /note="M -> T (in dbSNP:rs17596519)"
FT /id="VAR_053215"
FT VARIANT 163
FT /note="A -> P (in dbSNP:rs17148883)"
FT /id="VAR_034236"
FT VARIANT 189
FT /note="R -> C (in dbSNP:rs2457239)"
FT /id="VAR_034237"
FT VARIANT 215
FT /note="F -> L (in dbSNP:rs17596422)"
FT /id="VAR_053216"
FT VARIANT 310
FT /note="F -> Y (in dbSNP:rs34573569)"
FT /id="VAR_062046"
SQ SEQUENCE 310 AA; 35167 MW; FFC0A71D4A2D0768 CRC64;
MDWENCSSLT DFFLLGITNN PEMKVTLFAV FLAVYIINFS ANLGMIVLIR MDYQLHTPMY
FFLSHLSFCD LCYSTATGPK MLVDLLAKNK SIPFYGCALQ FLVFCIFADS ECLLLSVMAF
DRYKAIINPL LYTVNMSSRV CYLLLTGVYL VGIADALIHM TLAFRLCFCG SNEINHFFCD
IPPLLLLSRS DTQVNELVLF TVFGFIELST ISGVFISYCY IILSVLEIHS AEGRFKALST
CTSHLSAVAI FQGTLLFMYF RPSSSYSLDQ DKMTSLFYTL VVPMLNPLIY SLRNKDVKEA
LKKLKNKILF
