OR67D_DROME
ID OR67D_DROME Reviewed; 391 AA.
AC Q9VT92;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 3.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Odorant receptor 67d;
GN Name=Or67d; ORFNames=CG14157;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|EMBL:AAF50161.3};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16928861; DOI=10.1523/jneurosci.0876-06.2006;
RA Ha T.S., Smith D.P.;
RT "A pheromone receptor mediates 11-cis-vaccenyl acetate-induced responses in
RT Drosophila.";
RL J. Neurosci. 26:8727-8733(2006).
RN [4]
RP FUNCTION.
RX PubMed=17363250; DOI=10.1016/j.cub.2007.01.053;
RA Ejima A., Smith B.P., Lucas C., van der Goes van Naters W., Miller C.J.,
RA Carlson J.R., Levine J.D., Griffith L.C.;
RT "Generalization of courtship learning in Drosophila is mediated by cis-
RT vaccenyl acetate.";
RL Curr. Biol. 17:599-605(2007).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=17392786; DOI=10.1038/nature05672;
RA Kurtovic A., Widmer A., Dickson B.J.;
RT "A single class of olfactory neurons mediates behavioural responses to a
RT Drosophila sex pheromone.";
RL Nature 446:542-546(2007).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17943085; DOI=10.1038/nature06328;
RA Benton R., Vannice K.S., Vosshall L.B.;
RT "An essential role for a CD36-related receptor in pheromone detection in
RT Drosophila.";
RL Nature 450:289-293(2007).
RN [7]
RP FUNCTION.
RX PubMed=18305480; DOI=10.1038/nature06808;
RA Datta S.R., Vasconcelos M.L., Ruta V., Luo S., Wong A., Demir E.,
RA Flores J., Balonze K., Dickson B.J., Axel R.;
RT "The Drosophila pheromone cVA activates a sexually dimorphic neural
RT circuit.";
RL Nature 452:473-477(2008).
RN [8]
RP FUNCTION.
RX PubMed=19966787; DOI=10.1038/nature08678;
RA Wang L., Anderson D.J.;
RT "Identification of an aggression-promoting pheromone and its receptor
RT neurons in Drosophila.";
RL Nature 463:227-231(2010).
CC -!- FUNCTION: Plays a role in detection and sensitivity to pheromones and
CC signal transduction of the fatty-acid-derived male pheromone 11-cis
CC vaccenyl acetate (cVA). Acts in concert with Snmp and lush to capture
CC cVA molecules on the surface of Or67d expressing olfactory dendrites
CC and facilitate their transfer to the odorant-receptor Orco complex.
CC Necessary to mediate behavioral responses to cVA by regulating both
CC male and female mating behavior. Activation of Or67d neurons by cVA
CC inhibits courtship of other males, whereas in females their activation
CC promotes receptivity to other males. May form a complex with Orco to
CC form odorant-sensing units, providing sensitive and prolonged odorant
CC signaling and calcium permeability. {ECO:0000269|PubMed:16928861,
CC ECO:0000269|PubMed:17363250, ECO:0000269|PubMed:17392786,
CC ECO:0000269|PubMed:17943085, ECO:0000269|PubMed:18305480,
CC ECO:0000269|PubMed:19966787}.
CC -!- SUBUNIT: Interacts with Orco. Complexes exist early in the endomembrane
CC system in olfactory sensory neurons (OSNs), coupling these complexes to
CC the conserved ciliary trafficking pathway (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in antenna. {ECO:0000269|PubMed:16928861,
CC ECO:0000269|PubMed:17943085}.
CC -!- DISRUPTION PHENOTYPE: Mutant males inappropriately court other males,
CC whereas mutant females are less receptive to courting males.
CC {ECO:0000269|PubMed:17392786}.
CC -!- MISCELLANEOUS: The atypical heteromeric and topological design of the
CC odorant receptors appears to be an insect-specific solution for odor
CC recognition, making the OR/Orco complex an attractive target for the
CC development of highly selective insect repellents to disrupt olfactory-
CC mediated host-seeking behaviors of insect disease vectors. Odor-evoked
CC OR currents are independent of known G-protein-coupled second messenger
CC pathways.
CC -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
CC Heteromeric odorant receptor channel (TC 1.A.69) family. Or67d
CC subfamily. {ECO:0000305}.
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DR EMBL; AE014296; AAF50161.3; -; Genomic_DNA.
DR RefSeq; NP_648390.2; NM_140133.2.
DR AlphaFoldDB; Q9VT92; -.
DR SMR; Q9VT92; -.
DR BioGRID; 64572; 3.
DR STRING; 7227.FBpp0076026; -.
DR PaxDb; Q9VT92; -.
DR EnsemblMetazoa; FBtr0076297; FBpp0076026; FBgn0036080.
DR GeneID; 39191; -.
DR KEGG; dme:Dmel_CG14157; -.
DR CTD; 39191; -.
DR FlyBase; FBgn0036080; Or67d.
DR VEuPathDB; VectorBase:FBgn0036080; -.
DR eggNOG; ENOG502T8K4; Eukaryota.
DR GeneTree; ENSGT00530000064384; -.
DR HOGENOM; CLU_044523_2_0_1; -.
DR InParanoid; Q9VT92; -.
DR OMA; TNCLWYE; -.
DR OrthoDB; 1199681at2759; -.
DR PhylomeDB; Q9VT92; -.
DR BioGRID-ORCS; 39191; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 39191; -.
DR PRO; PR:Q9VT92; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036080; Expressed in antenna and 7 other tissues.
DR ExpressionAtlas; Q9VT92; baseline and differential.
DR Genevisible; Q9VT92; DM.
DR GO; GO:0032590; C:dendrite membrane; ISS:FlyBase.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0071683; C:sensory dendrite; IDA:FlyBase.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0016503; F:pheromone receptor activity; IMP:FlyBase.
DR GO; GO:0007619; P:courtship behavior; IMP:FlyBase.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IMP:FlyBase.
DR GO; GO:0043695; P:detection of pheromone; IMP:FlyBase.
DR GO; GO:0019236; P:response to pheromone; IMP:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; ISS:FlyBase.
DR InterPro; IPR004117; 7tm6_olfct_rcpt.
DR PANTHER; PTHR21137; PTHR21137; 1.
DR Pfam; PF02949; 7tm_6; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Olfaction; Receptor; Reference proteome;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..391
FT /note="Odorant receptor 67d"
FT /id="PRO_0000174265"
FT TOPO_DOM 1..45
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..71
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 93..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..164
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..191
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..297
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..391
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 391 AA; 44475 MW; 21C5FA6A69BE4C2F CRC64;
MLKMAKVEPV ERYCKVIRMI RFCVGFCGND VADPNFRMWW LTYAVMAAIA FFFACTGYTI
YVGVVINGDL TIILQALAMV GSAVQGLTKL LVTANNASHM REVQNTYEDI YREYGSKGDE
YAKCLEKRIR ITWTLLIGFM LVYIILLGLV ITFPIFYLLI LHQKVLVMQF LIPFLDHTTD
GGHLILTAAH VILITFGGFG NYGGDMYLFL FVTHVPLIKD IFCVKLTEFN ELVMKRNDFP
KVRAMLCDLL VWHQLYTRML QTTKKIYSIV LFVQLSTTCV GLLCTISCIF MKAWPAAPLY
LLYAAITLYT FCGLGTLVEN SNEDFLSVIY TNCLWYELPV KEEKLIIMML AKAQNEVVLT
AADMAPLSMN TALQLTKGIY SFSMMLMNYL G
