OR6A2_HUMAN
ID OR6A2_HUMAN Reviewed; 327 AA.
AC O95222; Q3MJC7; Q6IF35; Q9H206;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Olfactory receptor 6A2;
DE AltName: Full=Olfactory receptor 11-55;
DE Short=OR11-55;
DE AltName: Full=Olfactory receptor 6A1;
DE AltName: Full=Olfactory receptor OR11-83;
DE AltName: Full=hP2 olfactory receptor;
GN Name=OR6A2; Synonyms=OR6A1, OR6A2P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9787077; DOI=10.1006/geno.1998.5422;
RA Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A.;
RT "Organization and evolution of olfactory receptor genes on human chromosome
RT 11.";
RL Genomics 53:56-68(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11416212; DOI=10.1073/pnas.131215398;
RA Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L.,
RA Evans G., Axel R., Hood L., Trask B.J.;
RT "Genomic analysis of orthologous mouse and human olfactory receptor loci.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6A1";
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DR EMBL; AF065870; AAC70018.1; -; Genomic_DNA.
DR EMBL; AF321237; AAG45208.1; -; Genomic_DNA.
DR EMBL; AB065822; BAC06041.1; -; Genomic_DNA.
DR EMBL; BC101489; AAI01490.1; -; mRNA.
DR EMBL; BC101491; AAI01492.1; -; mRNA.
DR EMBL; BK004427; DAA04825.1; -; Genomic_DNA.
DR CCDS; CCDS7772.1; -.
DR RefSeq; NP_003687.2; NM_003696.2.
DR AlphaFoldDB; O95222; -.
DR SMR; O95222; -.
DR BioGRID; 114155; 4.
DR STRING; 9606.ENSP00000330384; -.
DR GlyGen; O95222; 2 sites.
DR BioMuta; OR6A2; -.
DR PaxDb; O95222; -.
DR PeptideAtlas; O95222; -.
DR PRIDE; O95222; -.
DR Antibodypedia; 54720; 46 antibodies from 16 providers.
DR DNASU; 8590; -.
DR Ensembl; ENST00000641196.1; ENSP00000492990.1; ENSG00000184933.6.
DR GeneID; 8590; -.
DR KEGG; hsa:8590; -.
DR MANE-Select; ENST00000641196.1; ENSP00000492990.1; NM_003696.3; NP_003687.2.
DR UCSC; uc001mes.2; human.
DR CTD; 8590; -.
DR GeneCards; OR6A2; -.
DR HGNC; HGNC:15301; OR6A2.
DR HPA; ENSG00000184933; Not detected.
DR MIM; 608495; gene.
DR neXtProt; NX_O95222; -.
DR PharmGKB; PA32574; -.
DR VEuPathDB; HostDB:ENSG00000184933; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01050000244853; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; O95222; -.
DR OMA; LHLYQGQ; -.
DR OrthoDB; 1148157at2759; -.
DR PhylomeDB; O95222; -.
DR TreeFam; TF337475; -.
DR PathwayCommons; O95222; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 8590; 7 hits in 669 CRISPR screens.
DR GeneWiki; OR6A2; -.
DR GenomeRNAi; 8590; -.
DR Pharos; O95222; Tdark.
DR PRO; PR:O95222; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; O95222; protein.
DR Bgee; ENSG00000184933; Expressed in anatomical system and 5 other tissues.
DR ExpressionAtlas; O95222; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; NAS:UniProtKB.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..327
FT /note="Olfactory receptor 6A2"
FT /id="PRO_0000150619"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..201
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 191
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 102..194
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 22
FT /note="A -> V (in dbSNP:rs7122644)"
FT /id="VAR_053217"
FT CONFLICT 22..27
FT /note="APLQVL -> VPIQVI (in Ref. 1; AAC70018)"
FT /evidence="ECO:0000305"
FT CONFLICT 125
FT /note="Y -> N (in Ref. 1; AAC70018/DAA04825)"
FT /evidence="ECO:0000305"
FT CONFLICT 134
FT /note="P -> L (in Ref. 1; AAC70018/DAA04825)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="Y -> N (in Ref. 1; AAC70018/DAA04825)"
FT /evidence="ECO:0000305"
FT CONFLICT 173..174
FT /note="YC -> NG (in Ref. 1; AAC70018/DAA04825)"
FT /evidence="ECO:0000305"
FT CONFLICT 250..251
FT /note="LT -> FN (in Ref. 1; AAC70018/DAA04825)"
FT /evidence="ECO:0000305"
FT CONFLICT 309
FT /note="T -> I (in Ref. 1; AAC70018/DAA04825)"
FT /evidence="ECO:0000305"
FT CONFLICT 323
FT /note="A -> G (in Ref. 1; AAC70018/DAA04825)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 327 AA; 36154 MW; 9C11914D3F069FC1 CRC64;
MEWRNHSGRV SEFVLLGFPA PAPLQVLLFA LLLLAYVLVL TENTLIIMAI RNHSTLHKPM
YFFLANMSFL EIWYVTVTIP KMLAGFVGSK QDHGQLISFE GCMTQLYFFL GLGCTECVLL
AVMAYDRYMA ICYPLHYPVI VSGRLCVQMA AGSWAGGFGI SMVKVFLISG LSYCGPNIIN
HFFCDVSPLL NLSCTDMSTA ELTDFILAIF ILLGPLSVTG ASYVAITGAV MHIPSAAGRY
KAFSTCASHL TVVIIFYAAS IFIYARPKAL SAFDTNKLVS VLYAVIVPLL NPIIYCLRNQ
EVKRALCCTL HLYQHQDPDP KKASRNV
