OR6B1_HUMAN
ID OR6B1_HUMAN Reviewed; 311 AA.
AC O95007; A4D2G2; B9EH47; Q6IFP6; Q96R38;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Olfactory receptor 6B1;
DE AltName: Full=Olfactory receptor 7-3;
DE Short=OR7-3;
DE AltName: Full=Olfactory receptor OR7-9;
GN Name=OR6B1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- INTERACTION:
CC O95007; O43186: CRX; NbExp=3; IntAct=EBI-12176191, EBI-748171;
CC O95007; Q0VD86: INCA1; NbExp=3; IntAct=EBI-12176191, EBI-6509505;
CC O95007; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12176191, EBI-16439278;
CC O95007; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-12176191, EBI-11139477;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6B1";
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DR EMBL; AC004853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236959; EAL23796.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC137042; AAI37043.1; -; mRNA.
DR EMBL; BC137047; AAI37048.1; -; mRNA.
DR EMBL; AF399605; AAK95090.1; -; Genomic_DNA.
DR EMBL; BK004216; DAA04614.1; -; Genomic_DNA.
DR CCDS; CCDS43667.1; -.
DR RefSeq; NP_001005281.1; NM_001005281.1.
DR AlphaFoldDB; O95007; -.
DR SMR; O95007; -.
DR BioGRID; 126443; 14.
DR IntAct; O95007; 4.
DR STRING; 9606.ENSP00000386151; -.
DR GlyGen; O95007; 1 site.
DR iPTMnet; O95007; -.
DR PhosphoSitePlus; O95007; -.
DR BioMuta; OR6B1; -.
DR PaxDb; O95007; -.
DR PeptideAtlas; O95007; -.
DR PRIDE; O95007; -.
DR Antibodypedia; 64075; 21 antibodies from 12 providers.
DR DNASU; 135946; -.
DR Ensembl; ENST00000408922.3; ENSP00000386151.2; ENSG00000221813.4.
DR Ensembl; ENST00000641698.1; ENSP00000492907.1; ENSG00000221813.4.
DR Ensembl; ENST00000642360.1; ENSP00000496557.1; ENSG00000284939.1.
DR Ensembl; ENST00000647270.1; ENSP00000494805.1; ENSG00000284939.1.
DR GeneID; 135946; -.
DR KEGG; hsa:135946; -.
DR MANE-Select; ENST00000641698.1; ENSP00000492907.1; NM_001005281.3; NP_001005281.1.
DR UCSC; uc003wdt.2; human.
DR CTD; 135946; -.
DR GeneCards; OR6B1; -.
DR HGNC; HGNC:8354; OR6B1.
DR HPA; ENSG00000221813; Not detected.
DR neXtProt; NX_O95007; -.
DR PharmGKB; PA32576; -.
DR VEuPathDB; HostDB:ENSG00000221813; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01050000244853; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; O95007; -.
DR OMA; ISLMCTE; -.
DR OrthoDB; 1148157at2759; -.
DR PhylomeDB; O95007; -.
DR TreeFam; TF337475; -.
DR PathwayCommons; O95007; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; O95007; -.
DR BioGRID-ORCS; 135946; 10 hits in 677 CRISPR screens.
DR ChiTaRS; OR6B1; human.
DR GeneWiki; OR6B1; -.
DR GenomeRNAi; 135946; -.
DR Pharos; O95007; Tdark.
DR PRO; PR:O95007; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; O95007; protein.
DR Bgee; ENSG00000221813; Expressed in placenta and 5 other tissues.
DR Genevisible; O95007; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 6B1"
FT /id="PRO_0000150620"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 143
FT /note="R -> C (in dbSNP:rs7787378)"
FT /id="VAR_034238"
SQ SEQUENCE 311 AA; 35299 MW; 671FD19658FE0616 CRC64;
MELENQTRVT KFILVGFPGS LSMRAAMFLI FLVAYILTVA ENVIIILLVL QNRPLHKPMY
FFLANLSFLE TWYISVTVPK LLFSFWSVNN SISFTLCMIQ LYFFIALMCT ECVLLAAMAY
DRYVAICRPL HYPTIMSHGL CFRLALGSWA IGFGISLAKI YFISCLSFCG PNVINHFFCD
ISPVLNLSCT DMSITELVDF ILALVIFLFP LFITVLSYGC ILATILCMPT GKQKAFSTCA
SHLVVVTIFY SAIIFMYARP RVIHAFNMNK IISIFYAIVT PSLNPFIYCL RNREVKEALK
KLAYCQASRS D
