OR6B2_HUMAN
ID OR6B2_HUMAN Reviewed; 312 AA.
AC Q6IFH4; B2RPR3; Q8NGW0;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Olfactory receptor 6B2;
DE AltName: Full=Olfactory receptor OR2-1;
GN Name=OR6B2; Synonyms=OR6B2P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04686.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6B2";
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DR EMBL; AB065663; BAC05889.1; -; Genomic_DNA.
DR EMBL; CH471063; EAW71176.1; -; Genomic_DNA.
DR EMBL; BC137561; AAI37562.1; -; mRNA.
DR EMBL; BC137562; AAI37563.1; -; mRNA.
DR EMBL; BK004288; DAA04686.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS46559.1; -.
DR RefSeq; NP_001005853.1; NM_001005853.1.
DR AlphaFoldDB; Q6IFH4; -.
DR SMR; Q6IFH4; -.
DR STRING; 9606.ENSP00000384563; -.
DR GlyGen; Q6IFH4; 1 site.
DR BioMuta; OR6B2; -.
DR DMDM; 84029382; -.
DR MassIVE; Q6IFH4; -.
DR PaxDb; Q6IFH4; -.
DR PeptideAtlas; Q6IFH4; -.
DR PRIDE; Q6IFH4; -.
DR Antibodypedia; 34510; 92 antibodies from 22 providers.
DR DNASU; 389090; -.
DR Ensembl; ENST00000319423.5; ENSP00000322435.5; ENSG00000182083.8.
DR GeneID; 389090; -.
DR KEGG; hsa:389090; -.
DR MANE-Select; ENST00000319423.5; ENSP00000322435.5; NM_001005853.1; NP_001005853.1.
DR UCSC; uc010zoc.3; human.
DR CTD; 389090; -.
DR GeneCards; OR6B2; -.
DR HGNC; HGNC:15041; OR6B2.
DR HPA; ENSG00000182083; Not detected.
DR neXtProt; NX_Q6IFH4; -.
DR PharmGKB; PA32577; -.
DR VEuPathDB; HostDB:ENSG00000182083; -.
DR eggNOG; ENOG502SJJZ; Eukaryota.
DR GeneTree; ENSGT01050000244870; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q6IFH4; -.
DR OMA; YWHITLA; -.
DR OrthoDB; 950937at2759; -.
DR PhylomeDB; Q6IFH4; -.
DR TreeFam; TF337475; -.
DR PathwayCommons; Q6IFH4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 389090; 14 hits in 633 CRISPR screens.
DR GeneWiki; OR6B2; -.
DR GenomeRNAi; 389090; -.
DR Pharos; Q6IFH4; Tdark.
DR PRO; PR:Q6IFH4; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q6IFH4; protein.
DR Bgee; ENSG00000182083; Expressed in tibial nerve and 14 other tissues.
DR ExpressionAtlas; Q6IFH4; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 6B2"
FT /id="PRO_0000150621"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 179
FT /note="C -> R (in dbSNP:rs10187574)"
FT /id="VAR_062047"
FT VARIANT 227
FT /note="R -> C (in dbSNP:rs60841887)"
FT /id="VAR_062048"
SQ SEQUENCE 312 AA; 35029 MW; 56D388B1AF4799FA CRC64;
MSGENVTKVS TFILVGLPTA PGLQYLLFLL FLLTYLFVLV ENLAIILIVW SSTSLHRPMY
YFLSSMSFLE IWYVSDITPK MLEGFLLQQK RISFVGCMTQ LYFFSSLVCT ECVLLASMAY
DRYVAICHPL RYHVLVTPGL CLQLVGFSFV SGFTISMIKV CFISSVTFCG SNVLNHFFCD
ISPILKLACT DFSTAELVDF ILAFIILVFP LLATILSYWH ITLAVLRIPS ATGCWRAFST
CASHLTVVTV FYTALLFMYV RPQAIDSQSS NKLISAVYTV VTPIINPLIY CLRNKEFKDA
LKKALGLGQT SH
