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OR6B3_HUMAN
ID   OR6B3_HUMAN             Reviewed;         331 AA.
AC   Q8NGW1; Q6IFH3;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 149.
DE   RecName: Full=Olfactory receptor 6B3;
DE   AltName: Full=Olfactory receptor OR2-2;
GN   Name=OR6B3; Synonyms=OR6B3P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [3]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=DAA04687.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6B3";
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DR   EMBL; AB065662; BAC05888.1; -; Genomic_DNA.
DR   EMBL; BK004289; DAA04687.1; ALT_INIT; Genomic_DNA.
DR   CCDS; CCDS42837.1; -.
DR   RefSeq; NP_775486.1; NM_173351.1.
DR   AlphaFoldDB; Q8NGW1; -.
DR   SMR; Q8NGW1; -.
DR   BioGRID; 127316; 3.
DR   IntAct; Q8NGW1; 1.
DR   STRING; 9606.ENSP00000322435; -.
DR   GlyGen; Q8NGW1; 1 site.
DR   PhosphoSitePlus; Q8NGW1; -.
DR   BioMuta; OR6B3; -.
DR   DMDM; 38258179; -.
DR   MassIVE; Q8NGW1; -.
DR   PaxDb; Q8NGW1; -.
DR   PeptideAtlas; Q8NGW1; -.
DR   PRIDE; Q8NGW1; -.
DR   ProteomicsDB; 73611; -.
DR   Antibodypedia; 66158; 31 antibodies from 16 providers.
DR   DNASU; 150681; -.
DR   Ensembl; ENST00000641019.1; ENSP00000493035.1; ENSG00000178586.6.
DR   GeneID; 150681; -.
DR   KEGG; hsa:150681; -.
DR   UCSC; uc010zoe.2; human.
DR   CTD; 150681; -.
DR   GeneCards; OR6B3; -.
DR   HGNC; HGNC:15042; OR6B3.
DR   HPA; ENSG00000178586; Tissue enriched (retina).
DR   neXtProt; NX_Q8NGW1; -.
DR   OpenTargets; ENSG00000178586; -.
DR   PharmGKB; PA32578; -.
DR   VEuPathDB; HostDB:ENSG00000178586; -.
DR   eggNOG; ENOG502SJJZ; Eukaryota.
DR   GeneTree; ENSGT01050000244870; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NGW1; -.
DR   OMA; WANTSLH; -.
DR   OrthoDB; 950937at2759; -.
DR   PhylomeDB; Q8NGW1; -.
DR   TreeFam; TF337475; -.
DR   PathwayCommons; Q8NGW1; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q8NGW1; -.
DR   BioGRID-ORCS; 150681; 8 hits in 671 CRISPR screens.
DR   GeneWiki; OR6B3; -.
DR   GenomeRNAi; 150681; -.
DR   Pharos; Q8NGW1; Tdark.
DR   PRO; PR:Q8NGW1; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q8NGW1; protein.
DR   Bgee; ENSG00000178586; Expressed in tibial nerve and 30 other tissues.
DR   ExpressionAtlas; Q8NGW1; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..331
FT                   /note="Olfactory receptor 6B3"
FT                   /id="PRO_0000150622"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..331
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         234
FT                   /note="C -> Y (in dbSNP:rs12465491)"
FT                   /id="VAR_062049"
SQ   SEQUENCE   331 AA;  37232 MW;  88E9369D2BAB6244 CRC64;
     MSGENVTRVG TFILVGFPTA PGLQYLLFLL FLLTYLFVLV ENLAIILTVW SSTSLHRPMY
     YFLSSMSFLE IWYVSDITPK MLEGFLLQQK RISFVGCMTQ LYFFSSLVCT ECVLLASMAY
     DRYVAICHPL RYHVLVTPGL CLQLVGFSFV SGFTISMIKV CFISSVTFCG SNVLNHFFCD
     ISPILKLACT DFSTAELVDF ILAFIILVFP LLATMLSYAH ITLAVLRIPS ATGCWRAFFT
     CASHLTVVTV FYTALLFMYV RPQAIDSRSS NKLISVLYTV ITPILNPLIY CLRNKEFKNA
     LKKAFGLTSC AVEGRLSSLL ELHLQIHSQP L
 
 
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