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OR6C2_HUMAN
ID   OR6C2_HUMAN             Reviewed;         312 AA.
AC   Q9NZP2;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 2.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Olfactory receptor 6C2;
DE   AltName: Full=HSA3;
GN   Name=OR6C2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16541075; DOI=10.1038/nature04569;
RA   Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA   Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA   Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA   Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA   Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA   Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA   Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA   Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA   Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA   Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA   Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA   Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA   Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA   Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA   Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA   Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA   Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA   David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA   D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA   Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA   Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA   Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA   LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA   Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA   Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA   Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA   Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA   Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA   Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA   Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA   Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA   Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA   Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA   Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA   Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA   Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA   Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA   Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA   Gibbs R.A.;
RT   "The finished DNA sequence of human chromosome 12.";
RL   Nature 440:346-351(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 122-283, AND VARIANT PRO-209.
RX   PubMed=10706615; DOI=10.1073/pnas.040580197;
RA   Rouquier S., Blancher A., Giorgi D.;
RT   "The olfactory receptor gene repertoire in primates and mouse: evidence for
RT   reduction of the functional fraction in primates.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6C2";
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DR   EMBL; AC122685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF179766; AAF40351.1; -; Genomic_DNA.
DR   CCDS; CCDS31824.1; -.
DR   RefSeq; NP_473446.1; NM_054105.1.
DR   AlphaFoldDB; Q9NZP2; -.
DR   SMR; Q9NZP2; -.
DR   STRING; 9606.ENSP00000323606; -.
DR   GlyGen; Q9NZP2; 2 sites.
DR   iPTMnet; Q9NZP2; -.
DR   PhosphoSitePlus; Q9NZP2; -.
DR   BioMuta; OR6C2; -.
DR   DMDM; 85541047; -.
DR   MassIVE; Q9NZP2; -.
DR   PaxDb; Q9NZP2; -.
DR   PeptideAtlas; Q9NZP2; -.
DR   PRIDE; Q9NZP2; -.
DR   Antibodypedia; 58545; 42 antibodies from 14 providers.
DR   DNASU; 341416; -.
DR   Ensembl; ENST00000641202.1; ENSP00000493222.1; ENSG00000179695.3.
DR   Ensembl; ENST00000641516.1; ENSP00000493456.1; ENSG00000179695.3.
DR   GeneID; 341416; -.
DR   KEGG; hsa:341416; -.
DR   MANE-Select; ENST00000641202.1; ENSP00000493222.1; NM_054105.2; NP_473446.1.
DR   UCSC; uc001sgz.1; human.
DR   CTD; 341416; -.
DR   GeneCards; OR6C2; -.
DR   HGNC; HGNC:15436; OR6C2.
DR   HPA; ENSG00000179695; Not detected.
DR   neXtProt; NX_Q9NZP2; -.
DR   OpenTargets; ENSG00000179695; -.
DR   PharmGKB; PA32580; -.
DR   VEuPathDB; HostDB:ENSG00000179695; -.
DR   eggNOG; ENOG502T9K4; Eukaryota.
DR   GeneTree; ENSGT00960000186600; -.
DR   HOGENOM; CLU_012526_1_1_1; -.
DR   InParanoid; Q9NZP2; -.
DR   OMA; QVKQAFY; -.
DR   OrthoDB; 894124at2759; -.
DR   PhylomeDB; Q9NZP2; -.
DR   TreeFam; TF336833; -.
DR   PathwayCommons; Q9NZP2; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q9NZP2; -.
DR   BioGRID-ORCS; 341416; 9 hits in 666 CRISPR screens.
DR   GeneWiki; OR6C2; -.
DR   GenomeRNAi; 341416; -.
DR   Pharos; Q9NZP2; Tdark.
DR   PRO; PR:Q9NZP2; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q9NZP2; protein.
DR   ExpressionAtlas; Q9NZP2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 6C2"
FT                   /id="PRO_0000150624"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..44
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        45..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..97
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..215
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..269
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        82
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         181
FT                   /note="P -> A (in dbSNP:rs11171466)"
FT                   /id="VAR_034243"
FT   VARIANT         209
FT                   /note="L -> P (in dbSNP:rs11171467)"
FT                   /evidence="ECO:0000269|PubMed:10706615"
FT                   /id="VAR_034244"
SQ   SEQUENCE   312 AA;  35178 MW;  8362872FB2D1CE23 CRC64;
     MKNHTVIRTF ILLGLTGDPH LQVLLFIFLF LTYMLSVTGN LTIITLTLVD HHLKTPMYFF
     LRNFSFLEVS FTTVCIPRFL YNISMGDNTI TYNACASQIF FVILFGATEF FLLAAMSYDR
     YVAICKPLHY VVIMNNRVCT LLVLCCWVAG LMIIVPPLSL GLQLEFCDSN AIDHFSCDAG
     PLLKISCSDT WVIEQMVILM AVFALIITLV CVILSYLYIV RTILKFPSVQ QRKKAFSTCS
     SHMIVVSIAY GSCIFIYIKP SAKDEVAINK GVSVLTTSVA PLLNPFIYTL RNKQVKQAFS
     DSIKRIAFLS KK
 
 
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