OR6C3_HUMAN
ID OR6C3_HUMAN Reviewed; 311 AA.
AC Q9NZP0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Olfactory receptor 6C3;
DE AltName: Full=HSA8;
GN Name=OR6C3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 121-282.
RX PubMed=10706615; DOI=10.1073/pnas.040580197;
RA Rouquier S., Blancher A., Giorgi D.;
RT "The olfactory receptor gene repertoire in primates and mouse: evidence for
RT reduction of the functional fraction in primates.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:2870-2874(2000).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6C3";
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DR EMBL; AC122684; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF179770; AAF40353.1; -; Genomic_DNA.
DR CCDS; CCDS31819.1; -.
DR RefSeq; NP_473445.1; NM_054104.1.
DR AlphaFoldDB; Q9NZP0; -.
DR SMR; Q9NZP0; -.
DR IntAct; Q9NZP0; 1.
DR STRING; 9606.ENSP00000368989; -.
DR GlyGen; Q9NZP0; 1 site.
DR iPTMnet; Q9NZP0; -.
DR PhosphoSitePlus; Q9NZP0; -.
DR BioMuta; OR6C3; -.
DR DMDM; 85541048; -.
DR MassIVE; Q9NZP0; -.
DR PaxDb; Q9NZP0; -.
DR PRIDE; Q9NZP0; -.
DR Antibodypedia; 58539; 51 antibodies from 16 providers.
DR DNASU; 254786; -.
DR Ensembl; ENST00000641364.1; ENSP00000493034.1; ENSG00000205329.3.
DR Ensembl; ENST00000641740.2; ENSP00000493380.1; ENSG00000205329.3.
DR GeneID; 254786; -.
DR KEGG; hsa:254786; -.
DR MANE-Select; ENST00000641740.2; ENSP00000493380.1; NM_001388498.1; NP_001375427.1.
DR UCSC; uc010spj.2; human.
DR CTD; 254786; -.
DR GeneCards; OR6C3; -.
DR HGNC; HGNC:15437; OR6C3.
DR HPA; ENSG00000205329; Not detected.
DR neXtProt; NX_Q9NZP0; -.
DR PharmGKB; PA32581; -.
DR VEuPathDB; HostDB:ENSG00000205329; -.
DR eggNOG; ENOG502RDVH; Eukaryota.
DR GeneTree; ENSGT01040000240425; -.
DR HOGENOM; CLU_012526_1_1_1; -.
DR InParanoid; Q9NZP0; -.
DR OMA; DYCASNI; -.
DR OrthoDB; 917809at2759; -.
DR PhylomeDB; Q9NZP0; -.
DR TreeFam; TF336833; -.
DR PathwayCommons; Q9NZP0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 254786; 1 hit in 665 CRISPR screens.
DR GeneWiki; OR6C3; -.
DR GenomeRNAi; 254786; -.
DR Pharos; Q9NZP0; Tdark.
DR PRO; PR:Q9NZP0; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9NZP0; protein.
DR Bgee; ENSG00000205329; Expressed in fundus of stomach.
DR ExpressionAtlas; Q9NZP0; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 6C3"
FT /id="PRO_0000150625"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..51
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..214
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 94..186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 69
FT /note="S -> L (in dbSNP:rs4318060)"
FT /id="VAR_053218"
FT VARIANT 133
FT /note="M -> T (in dbSNP:rs11835321)"
FT /id="VAR_053219"
FT VARIANT 234
FT /note="A -> S (in dbSNP:rs11832940)"
FT /id="VAR_034245"
SQ SEQUENCE 311 AA; 35531 MW; 1C5D41AA2738DA91 CRC64;
MNHTMVTEFV LLGLSDDPDL QIVIFLFLFI TYILSVTGNL TIITLTFVDS HLQTPMYFFL
RNFSFLEISF TTVCIPRFLG AIITRNKTIS YNNCAAQLFF FIFMGVTEFY ILTAMSYDRY
VAICKPLHYT SIMNRKLCTL LVLCAWLSGF LTIFPPLMLL LQLDYCASNV IDHFACDYFP
LLQLSCSDTW LLEVIGFYFA LVTLLFTLAL VILSYMYIIR TILRIPSASQ RKKAFSTCSS
HMIVISISYG SCIFMYANPS AKEKASLTKG IAILNTSVAP MLNPFIYTLR NQQVKQAFKN
VVHKVVFYAN Q
