OR6F1_HUMAN
ID OR6F1_HUMAN Reviewed; 308 AA.
AC Q8NGZ6; B2RNV6; Q6IF02; Q96R39;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Olfactory receptor 6F1;
DE AltName: Full=Olfactory receptor OR1-38;
GN Name=OR6F1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6F1";
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DR EMBL; AB065619; BAC05846.1; -; Genomic_DNA.
DR EMBL; CH471148; EAW77199.1; -; Genomic_DNA.
DR EMBL; BC137142; AAI37143.1; -; mRNA.
DR EMBL; BC137143; AAI37144.1; -; mRNA.
DR EMBL; AF399604; AAK95089.1; -; Genomic_DNA.
DR EMBL; BK004460; DAA04858.1; -; Genomic_DNA.
DR CCDS; CCDS31095.1; -.
DR RefSeq; NP_001005286.1; NM_001005286.1.
DR AlphaFoldDB; Q8NGZ6; -.
DR SMR; Q8NGZ6; -.
DR STRING; 9606.ENSP00000305640; -.
DR GlyGen; Q8NGZ6; 1 site.
DR iPTMnet; Q8NGZ6; -.
DR PhosphoSitePlus; Q8NGZ6; -.
DR BioMuta; OR6F1; -.
DR DMDM; 38372796; -.
DR MassIVE; Q8NGZ6; -.
DR PaxDb; Q8NGZ6; -.
DR PeptideAtlas; Q8NGZ6; -.
DR PRIDE; Q8NGZ6; -.
DR Antibodypedia; 76510; 6 antibodies from 6 providers.
DR DNASU; 343169; -.
DR Ensembl; ENST00000641444.1; ENSP00000493324.1; ENSG00000169214.5.
DR Ensembl; ENST00000641470.1; ENSP00000493342.1; ENSG00000169214.5.
DR GeneID; 343169; -.
DR KEGG; hsa:343169; -.
DR MANE-Select; ENST00000641470.1; ENSP00000493342.1; NM_001005286.2; NP_001005286.1.
DR UCSC; uc001idj.1; human.
DR CTD; 343169; -.
DR DisGeNET; 343169; -.
DR GeneCards; OR6F1; -.
DR HGNC; HGNC:15027; OR6F1.
DR HPA; ENSG00000169214; Tissue enriched (testis).
DR neXtProt; NX_Q8NGZ6; -.
DR PharmGKB; PA32585; -.
DR VEuPathDB; HostDB:ENSG00000169214; -.
DR eggNOG; ENOG502SIF0; Eukaryota.
DR GeneTree; ENSGT01050000244938; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGZ6; -.
DR OMA; LGSWICG; -.
DR OrthoDB; 1214979at2759; -.
DR PhylomeDB; Q8NGZ6; -.
DR TreeFam; TF337475; -.
DR PathwayCommons; Q8NGZ6; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 343169; 127 hits in 672 CRISPR screens.
DR GeneWiki; OR6F1; -.
DR GenomeRNAi; 343169; -.
DR Pharos; Q8NGZ6; Tdark.
DR PRO; PR:Q8NGZ6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGZ6; protein.
DR Bgee; ENSG00000169214; Expressed in left testis and 1 other tissue.
DR ExpressionAtlas; Q8NGZ6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..308
FT /note="Olfactory receptor 6F1"
FT /id="PRO_0000150627"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 13
FT /note="L -> P (in dbSNP:rs60303431)"
FT /id="VAR_062051"
FT VARIANT 159
FT /note="P -> A (in dbSNP:rs6665599)"
FT /id="VAR_053221"
FT VARIANT 215
FT /note="F -> L (in dbSNP:rs2282316)"
FT /id="VAR_034247"
SQ SEQUENCE 308 AA; 33961 MW; 05D63EE27E50E7CC CRC64;
MDTGNKTLPQ DFLLLGFPGS QTLQLSLFML FLVMYILTVS GNVAILMLVS TSHQLHTPMY
FFLSNLSFLE IWYTTAAVPK ALAILLGRSQ TISFTSCLLQ MYFVFSLGCT EYFLLAAMAY
DRCLAICYPL HYGAIMSSLL SAQLALGSWV CGFVAIAVPT ALISGLSFCG PRAINHFFCD
IAPWIALACT NTQAVELVAF VIAVVVILSS CLITFVSYVY IISTILRIPS ASGRSKAFST
CSSHLTVVLI WYGSTVFLHV RTSIKDALDL IKAVHVLNTV VTPVLNPFIY TLRNKEVRET
LLKKWKGK
