OR6K3_HUMAN
ID OR6K3_HUMAN Reviewed; 331 AA.
AC Q8NGY3; Q5VUV0; Q6IFR5;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Olfactory receptor 6K3;
DE AltName: Full=Olfactory receptor OR1-18;
GN Name=OR6K3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP IDENTIFICATION, AND VARIANTS SER-244 AND LEU-264.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [5]
RP VARIANT MET-216.
RX PubMed=21248752; DOI=10.1038/nature09639;
RA Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H.,
RA Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J.,
RA Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M.,
RA Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L.,
RA Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J.,
RA Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A.,
RA Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K.,
RA Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.;
RT "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene
RT PBRM1 in renal carcinoma.";
RL Nature 469:539-542(2011).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: It is uncertain whether Met-1, Met-5 or Met-17 is the
CC initiator. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05859.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6K3";
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DR EMBL; AB065633; BAC05859.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL513205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004197; DAA04595.1; -; Genomic_DNA.
DR RefSeq; NP_001005327.2; NM_001005327.2.
DR AlphaFoldDB; Q8NGY3; -.
DR SMR; Q8NGY3; -.
DR BioGRID; 133807; 4.
DR IntAct; Q8NGY3; 1.
DR MINT; Q8NGY3; -.
DR STRING; 9606.ENSP00000357127; -.
DR GlyGen; Q8NGY3; 3 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q8NGY3; -.
DR PhosphoSitePlus; Q8NGY3; -.
DR BioMuta; OR6K3; -.
DR DMDM; 229462932; -.
DR PaxDb; Q8NGY3; -.
DR PRIDE; Q8NGY3; -.
DR Antibodypedia; 20464; 109 antibodies from 23 providers.
DR DNASU; 391114; -.
DR Ensembl; ENST00000368146.1; ENSP00000357128.1; ENSG00000203757.2.
DR GeneID; 391114; -.
DR KEGG; hsa:391114; -.
DR UCSC; uc021pbn.1; human.
DR CTD; 391114; -.
DR GeneCards; OR6K3; -.
DR HGNC; HGNC:15030; OR6K3.
DR HPA; ENSG00000203757; Tissue enriched (bone).
DR neXtProt; NX_Q8NGY3; -.
DR PharmGKB; PA32590; -.
DR VEuPathDB; HostDB:ENSG00000203757; -.
DR eggNOG; ENOG502T9P2; Eukaryota.
DR GeneTree; ENSGT00940000162973; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q8NGY3; -.
DR OrthoDB; 821634at2759; -.
DR PhylomeDB; Q8NGY3; -.
DR TreeFam; TF337307; -.
DR PathwayCommons; Q8NGY3; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGY3; -.
DR BioGRID-ORCS; 391114; 6 hits in 655 CRISPR screens.
DR GenomeRNAi; 391114; -.
DR Pharos; Q8NGY3; Tdark.
DR PRO; PR:Q8NGY3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGY3; protein.
DR Bgee; ENSG00000203757; Expressed in bone marrow and 9 other tissues.
DR ExpressionAtlas; Q8NGY3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..331
FT /note="Olfactory receptor 6K3"
FT /id="PRO_0000150630"
FT TOPO_DOM 1..41
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..115
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..155
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..212
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..252
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 274..286
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 113..205
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 20
FT /note="G -> R (in dbSNP:rs857705)"
FT /id="VAR_055066"
FT VARIANT 159
FT /note="Q -> H (in dbSNP:rs857704)"
FT /id="VAR_062052"
FT VARIANT 216
FT /note="V -> M (found in a renal cell carcinoma sample;
FT somatic mutation; dbSNP:rs151330882)"
FT /evidence="ECO:0000269|PubMed:21248752"
FT /id="VAR_064741"
FT VARIANT 244
FT /note="P -> S (in dbSNP:rs857703)"
FT /evidence="ECO:0000269|PubMed:14983052"
FT /id="VAR_055067"
FT VARIANT 264
FT /note="P -> L (in dbSNP:rs28568406)"
FT /evidence="ECO:0000269|PubMed:14983052"
FT /id="VAR_055068"
FT VARIANT 279
FT /note="D -> N (in dbSNP:rs857702)"
FT /id="VAR_062053"
FT VARIANT 308
FT /note="R -> K (in dbSNP:rs16840675)"
FT /id="VAR_055069"
SQ SEQUENCE 331 AA; 37352 MW; 737256228FDC5773 CRC64;
MCWTMPSPFT GSSTRNMESG NQSTVTEFIF TGFPQLQDGS LLYFFPLLFI YTFIIIDNLL
IFSAVRLDTH LHNPMYNFIS IFSFLEIWYT TATIPKMLSN LISEKKAISM TGCILQMYFF
HSLENSEGIL LTTMAIDRYV AICNPLRYQM IMTPRLCAQL SAGSCLFGFL ILLPEIVMIS
TLPFCGPNQI HQIFCDLVPV LSLACTDTSM ILIEDVIHAV TIIITFLIIA LSYVRIVTVI
LRIPSSEGRQ KAFSTCAGHL MVFPIFFGSV SLMYLRFSDT YPPVLDTAIA LMFTVLAPFF
NPIIYSLRNK DMNNAIKKLF CLQKVLNKPG G
