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OR6K6_HUMAN
ID   OR6K6_HUMAN             Reviewed;         343 AA.
AC   Q8NGW6; B9EIM8; Q5VUU9; Q6IFR4;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Olfactory receptor 6K6;
DE   AltName: Full=Olfactory receptor OR1-21;
GN   Name=OR6K6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-25 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC05876.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6K6";
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DR   EMBL; AB065650; BAC05876.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL513205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC140743; AAI40744.1; -; mRNA.
DR   EMBL; BK004198; DAA04596.1; -; Genomic_DNA.
DR   RefSeq; NP_001005184.1; NM_001005184.1.
DR   AlphaFoldDB; Q8NGW6; -.
DR   SMR; Q8NGW6; -.
DR   STRING; 9606.ENSP00000357126; -.
DR   GlyGen; Q8NGW6; 1 site.
DR   iPTMnet; Q8NGW6; -.
DR   PhosphoSitePlus; Q8NGW6; -.
DR   BioMuta; OR6K6; -.
DR   DMDM; 223590118; -.
DR   PaxDb; Q8NGW6; -.
DR   PeptideAtlas; Q8NGW6; -.
DR   PRIDE; Q8NGW6; -.
DR   Antibodypedia; 68463; 76 antibodies from 18 providers.
DR   DNASU; 128371; -.
DR   GeneID; 128371; -.
DR   KEGG; hsa:128371; -.
DR   UCSC; uc001fsw.2; human.
DR   CTD; 128371; -.
DR   GeneCards; OR6K6; -.
DR   HGNC; HGNC:15033; OR6K6.
DR   HPA; ENSG00000180433; Not detected.
DR   neXtProt; NX_Q8NGW6; -.
DR   PharmGKB; PA32593; -.
DR   VEuPathDB; HostDB:ENSG00000180433; -.
DR   eggNOG; ENOG502T1JP; Eukaryota.
DR   HOGENOM; CLU_012526_0_1_1; -.
DR   InParanoid; Q8NGW6; -.
DR   OMA; FIVIQVD; -.
DR   OrthoDB; 974750at2759; -.
DR   PhylomeDB; Q8NGW6; -.
DR   TreeFam; TF337562; -.
DR   PathwayCommons; Q8NGW6; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 128371; 7 hits in 667 CRISPR screens.
DR   GeneWiki; OR6K6; -.
DR   GenomeRNAi; 128371; -.
DR   Pharos; Q8NGW6; Tdark.
DR   PRO; PR:Q8NGW6; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8NGW6; protein.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..343
FT                   /note="Olfactory receptor 6K6"
FT                   /id="PRO_0000150631"
FT   TOPO_DOM        1..53
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..74
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        75..82
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        104..127
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        149..167
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        189..224
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..244
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        245..264
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        286..298
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        320..343
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        125..217
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         39
FT                   /note="E -> D (in dbSNP:rs16840974)"
FT                   /id="VAR_057551"
FT   VARIANT         49
FT                   /note="H -> Y (in dbSNP:rs16840976)"
FT                   /id="VAR_057552"
FT   VARIANT         80
FT                   /note="G -> D (in dbSNP:rs16840980)"
FT                   /id="VAR_057553"
FT   VARIANT         134
FT                   /note="S -> L (in dbSNP:rs16840991)"
FT                   /id="VAR_057554"
FT   VARIANT         159
FT                   /note="R -> C (in dbSNP:rs16841001)"
FT                   /id="VAR_057555"
FT   VARIANT         197
FT                   /note="C -> R (in dbSNP:rs16841009)"
FT                   /id="VAR_057556"
FT   VARIANT         211
FT                   /note="P -> L (in dbSNP:rs16841017)"
FT                   /id="VAR_057557"
FT   VARIANT         247
FT                   /note="R -> Q (in dbSNP:rs16841038)"
FT                   /id="VAR_057558"
FT   VARIANT         261
FT                   /note="H -> R (in dbSNP:rs16841042)"
FT                   /id="VAR_057559"
FT   VARIANT         320
FT                   /note="K -> R (in dbSNP:rs16841045)"
FT                   /id="VAR_057560"
SQ   SEQUENCE   343 AA;  38362 MW;  0786F45F4BA67CBB CRC64;
     MKQYSVGNQH SNYRSLLFPF LCSQMTQLTA SGNQTMVTEF LFSMFPHAHR GGLLFFIPLL
     LIYGFILTGN LIMFIVIQVG MALHTPLYFF ISVLSFLEIC YTTTTIPKML SCLISEQKSI
     SVAGCLLQMY FFHSLGITES CVLTAMAIDR YIAICNPLRY PTIMIPKLCI QLTVGSCFCG
     FLLVLPEIAW ISTLPFCGSN QIHQIFCDFT PVLSLACTDT FLVVIVDAIH AAEIVASFLV
     IALSYIRIII VILGMHSAEG HHKAFSTCAA HLAVFLLFFG SVAVMYLRFS ATYSVFWDTA
     IAVTFVILAP FFNPIIYSLK NKDMKEAIGR LFHYQKRAGW AGK
 
 
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