OR6M1_HUMAN
ID OR6M1_HUMAN Reviewed; 313 AA.
AC Q8NGM8; B2RNK0; Q6IEW9; Q96R37;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 6M1;
DE AltName: Full=Olfactory receptor OR11-271;
GN Name=OR6M1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-281.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6M1";
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DR EMBL; AB065762; BAC05982.1; -; Genomic_DNA.
DR EMBL; CH471065; EAW67556.1; -; Genomic_DNA.
DR EMBL; BC136929; AAI36930.1; -; mRNA.
DR EMBL; BC136931; AAI36932.1; -; mRNA.
DR EMBL; AF399606; AAK95091.1; -; Genomic_DNA.
DR EMBL; BK004493; DAA04891.1; -; Genomic_DNA.
DR CCDS; CCDS31696.1; -.
DR RefSeq; NP_001005325.1; NM_001005325.1.
DR AlphaFoldDB; Q8NGM8; -.
DR SMR; Q8NGM8; -.
DR BioGRID; 133477; 8.
DR STRING; 9606.ENSP00000311038; -.
DR GlyGen; Q8NGM8; 2 sites.
DR iPTMnet; Q8NGM8; -.
DR PhosphoSitePlus; Q8NGM8; -.
DR BioMuta; OR6M1; -.
DR MassIVE; Q8NGM8; -.
DR PaxDb; Q8NGM8; -.
DR PeptideAtlas; Q8NGM8; -.
DR PRIDE; Q8NGM8; -.
DR Antibodypedia; 63993; 38 antibodies from 16 providers.
DR DNASU; 390261; -.
DR Ensembl; ENST00000309154.3; ENSP00000311038.2; ENSG00000196099.5.
DR GeneID; 390261; -.
DR KEGG; hsa:390261; -.
DR MANE-Select; ENST00000309154.3; ENSP00000311038.2; NM_001005325.1; NP_001005325.1.
DR UCSC; uc010rzz.3; human.
DR CTD; 390261; -.
DR GeneCards; OR6M1; -.
DR HGNC; HGNC:14711; OR6M1.
DR HPA; ENSG00000196099; Not detected.
DR neXtProt; NX_Q8NGM8; -.
DR PharmGKB; PA32596; -.
DR VEuPathDB; HostDB:ENSG00000196099; -.
DR eggNOG; ENOG502SFXX; Eukaryota.
DR GeneTree; ENSGT01050000244938; -.
DR HOGENOM; CLU_012526_1_1_1; -.
DR InParanoid; Q8NGM8; -.
DR OMA; CRKEINH; -.
DR OrthoDB; 1140068at2759; -.
DR PhylomeDB; Q8NGM8; -.
DR TreeFam; TF336833; -.
DR PathwayCommons; Q8NGM8; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390261; 8 hits in 671 CRISPR screens.
DR GeneWiki; OR6M1; -.
DR GenomeRNAi; 390261; -.
DR Pharos; Q8NGM8; Tdark.
DR PRO; PR:Q8NGM8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGM8; protein.
DR Bgee; ENSG00000196099; Expressed in mucosa of transverse colon and 5 other tissues.
DR ExpressionAtlas; Q8NGM8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 6M1"
FT /id="PRO_0000150632"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..214
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 262
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 276
FT /note="T -> K (in dbSNP:rs4936845)"
FT /id="VAR_053222"
SQ SEQUENCE 313 AA; 35328 MW; 52794CB2134202CF CRC64;
MGNWSTVTEI TLIAFPALLE IRISLFVVLV VTYTLTATGN ITIISLIWID HRLQTPMYFF
LSNLSFLDIL YTTVITPKLL ACLLGEEKTI SFAGCMIQTY FYFFLGTVEF ILLAVMSFDR
YMAICDPLHY TVIMNSRACL LLVLGCWVGA FLSVLFPTIV VTRLPYCRKE INHFFCDIAP
LLQVACINTH LIEKINFLLS ALVILSSLAF TTGSYVYIIS TILRIPSTQG RQKAFSTCAS
HITVVSIAHG SNIFVYVRPN QNSSLDYDKV AAVLITVVTP LLNPFIYSLR NEKVQEVLRE
TVNRIMTLIQ RKT
