OR6N1_HUMAN
ID OR6N1_HUMAN Reviewed; 312 AA.
AC Q8NGY5; B2RUT4; Q5VUU8; Q96R35;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Olfactory receptor 6N1;
GN Name=OR6N1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LEU-245 AND ARG-261.
RX PubMed=25977809; DOI=10.1038/sdata.2015.2;
RA Mainland J.D., Li Y.R., Zhou T., Liu W.L., Matsunami H.;
RT "Human olfactory receptor responses to odorants.";
RL Sci. Data 2:150002-150002(2015).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LEU-245 AND ARG-261.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283, AND VARIANTS THR-194; LEU-245
RP AND ARG-261.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6N1";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065631; BAC05857.1; -; Genomic_DNA.
DR EMBL; KP290131; ALI87321.1; -; Genomic_DNA.
DR EMBL; AL513205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC146847; AAI46848.1; -; mRNA.
DR EMBL; AF399608; AAK95093.1; -; Genomic_DNA.
DR CCDS; CCDS30905.1; -.
DR RefSeq; NP_001005185.1; NM_001005185.1.
DR RefSeq; XP_016855814.1; XM_017000325.1.
DR RefSeq; XP_016855815.1; XM_017000326.1.
DR RefSeq; XP_016855816.1; XM_017000327.1.
DR AlphaFoldDB; Q8NGY5; -.
DR SMR; Q8NGY5; -.
DR BioGRID; 126117; 8.
DR STRING; 9606.ENSP00000335535; -.
DR GlyGen; Q8NGY5; 1 site.
DR iPTMnet; Q8NGY5; -.
DR PhosphoSitePlus; Q8NGY5; -.
DR BioMuta; OR6N1; -.
DR DMDM; 38372788; -.
DR MassIVE; Q8NGY5; -.
DR PaxDb; Q8NGY5; -.
DR PeptideAtlas; Q8NGY5; -.
DR PRIDE; Q8NGY5; -.
DR Antibodypedia; 34252; 75 antibodies from 22 providers.
DR DNASU; 128372; -.
DR Ensembl; ENST00000641846.1; ENSP00000493254.1; ENSG00000197403.5.
DR GeneID; 128372; -.
DR KEGG; hsa:128372; -.
DR MANE-Select; ENST00000641846.1; ENSP00000493254.1; NM_001005185.2; NP_001005185.1.
DR UCSC; uc010piq.2; human.
DR CTD; 128372; -.
DR DisGeNET; 128372; -.
DR GeneCards; OR6N1; -.
DR HGNC; HGNC:15034; OR6N1.
DR HPA; ENSG00000197403; Not detected.
DR neXtProt; NX_Q8NGY5; -.
DR OpenTargets; ENSG00000197403; -.
DR PharmGKB; PA32599; -.
DR VEuPathDB; HostDB:ENSG00000197403; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT00940000158895; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGY5; -.
DR OMA; HTPMYQF; -.
DR PhylomeDB; Q8NGY5; -.
DR TreeFam; TF337673; -.
DR PathwayCommons; Q8NGY5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 128372; 4 hits in 671 CRISPR screens.
DR ChiTaRS; OR6N1; human.
DR GeneWiki; OR6N1; -.
DR GenomeRNAi; 128372; -.
DR Pharos; Q8NGY5; Tdark.
DR PRO; PR:Q8NGY5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGY5; protein.
DR Bgee; ENSG00000197403; Expressed in bone marrow and 34 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 6N1"
FT /id="PRO_0000150633"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 10
FT /note="A -> T (in dbSNP:rs1864346)"
FT /id="VAR_024106"
FT VARIANT 194
FT /note="I -> T (in dbSNP:rs857827)"
FT /evidence="ECO:0000269|PubMed:12213199"
FT /id="VAR_024107"
FT VARIANT 245
FT /note="F -> L (in dbSNP:rs857826)"
FT /evidence="ECO:0000269|PubMed:12213199,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:25977809"
FT /id="VAR_053223"
FT VARIANT 261
FT /note="Q -> R (in dbSNP:rs857825)"
FT /evidence="ECO:0000269|PubMed:12213199,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:25977809"
FT /id="VAR_024108"
FT VARIANT 293
FT /note="R -> H (in dbSNP:rs857824)"
FT /id="VAR_024109"
FT CONFLICT 86
FT /note="L -> F (in Ref. 5; AAK95093)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 34869 MW; C29620BD9950DCB3 CRC64;
MDTGNWSQVA EFIILGFPHL QGVQIYLFLL LLLIYLMTVL GNLLIFLVVC LDSRLHTPMY
HFVSILSFSE LGYTAATIPK MLANLLSEKK TISFSGCLLQ IYFFHSLGAT ECYLLTAMAY
DRYLAICRPL HYPTLMTPTL CAEIAIGCWL GGLAGPVVEI SLISRLPFCG PNRIQHVFCD
FPPVLSLACT DTSINVLVDF VINSCKILAT FLLILCSYVQ IICTVLRIPS AAGKRKAIST
CASHFTVVLI FYGSILSMYV QLKKSYSLDY DQALAVVYSV LTPFLNPFIY SLRNKEIKEA
VRRQLKRIGI LA
