OR6S1_HUMAN
ID OR6S1_HUMAN Reviewed; 331 AA.
AC Q8NH40; Q6IFJ9;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Olfactory receptor 6S1;
DE AltName: Full=Olfactory receptor OR14-37;
GN Name=OR6S1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05799.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6S1";
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DR EMBL; AB065561; BAC05799.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BK004263; DAA04661.1; -; Genomic_DNA.
DR CCDS; CCDS32038.1; -.
DR RefSeq; NP_001001968.1; NM_001001968.1.
DR AlphaFoldDB; Q8NH40; -.
DR SMR; Q8NH40; -.
DR STRING; 9606.ENSP00000313110; -.
DR GlyGen; Q8NH40; 1 site.
DR BioMuta; OR6S1; -.
DR DMDM; 223590119; -.
DR PaxDb; Q8NH40; -.
DR PRIDE; Q8NH40; -.
DR ProteomicsDB; 73653; -.
DR Antibodypedia; 57711; 106 antibodies from 20 providers.
DR DNASU; 341799; -.
DR Ensembl; ENST00000320704.3; ENSP00000313110.3; ENSG00000181803.3.
DR GeneID; 341799; -.
DR KEGG; hsa:341799; -.
DR MANE-Select; ENST00000320704.3; ENSP00000313110.3; NM_001001968.1; NP_001001968.1.
DR UCSC; uc001vxv.1; human.
DR CTD; 341799; -.
DR GeneCards; OR6S1; -.
DR HGNC; HGNC:15363; OR6S1.
DR HPA; ENSG00000181803; Not detected.
DR neXtProt; NX_Q8NH40; -.
DR PharmGKB; PA32604; -.
DR VEuPathDB; HostDB:ENSG00000181803; -.
DR eggNOG; ENOG502SFXX; Eukaryota.
DR GeneTree; ENSGT01050000244938; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q8NH40; -.
DR OMA; DMFRKVV; -.
DR OrthoDB; 913196at2759; -.
DR PhylomeDB; Q8NH40; -.
DR TreeFam; TF336833; -.
DR PathwayCommons; Q8NH40; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 341799; 6 hits in 677 CRISPR screens.
DR GeneWiki; OR6S1; -.
DR GenomeRNAi; 341799; -.
DR Pharos; Q8NH40; Tdark.
DR PRO; PR:Q8NH40; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NH40; protein.
DR Bgee; ENSG00000181803; Expressed in lymph node and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..331
FT /note="Olfactory receptor 6S1"
FT /id="PRO_0000150637"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..207
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 229..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..182
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 42
FT /note="T -> I (in dbSNP:rs11622794)"
FT /id="VAR_057562"
FT VARIANT 156
FT /note="V -> I (in dbSNP:rs11622969)"
FT /id="VAR_057563"
FT VARIANT 237
FT /note="R -> H (in dbSNP:rs17277522)"
FT /id="VAR_057564"
FT VARIANT 296
FT /note="R -> C (in dbSNP:rs17114309)"
FT /id="VAR_057565"
SQ SEQUENCE 331 AA; 36127 MW; D7C1C3F266B336AB CRC64;
MSPDGNHSSD PTEFVLAGLP NLNSARVELF SVFLLVYLLN LTGNVLIVGV VRADTRLQTP
MYFFLGNLSC LEILLTSVII PKMLSNFLSR QHTISFAACI TQFYFYFFLG ASEFLLLAVM
SADRYLAICH PLRYPLLMSG AVCFRVALAC WVGGLVPVLG PTVAVALLPF CKQGAVVQHF
FCDSGPLLRL ACTNTKKLEE TDFVLASLVI VSSLLITAVS YGLIVLAVLS IPSASGRQKA
FSTCTSHLIV VTLFYGSAIF LYVRPSQSGS VDTNWAVTVI TTFVTPLLNP FIYALRNEQV
KEALKDMFRK VVAGVLGNLL LDKCLSEKAV K
