OR6T1_HUMAN
ID OR6T1_HUMAN Reviewed; 323 AA.
AC Q8NGN1; Q6IFE7;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Olfactory receptor 6T1;
DE AltName: Full=Olfactory receptor OR11-277;
GN Name=OR6T1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6T1";
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DR EMBL; AB065759; BAC05979.1; -; Genomic_DNA.
DR EMBL; CH471065; EAW67562.1; -; Genomic_DNA.
DR EMBL; BC136906; AAI36907.1; -; mRNA.
DR EMBL; BK004315; DAA04713.1; -; Genomic_DNA.
DR CCDS; CCDS31700.1; -.
DR RefSeq; NP_001005187.1; NM_001005187.1.
DR AlphaFoldDB; Q8NGN1; -.
DR SMR; Q8NGN1; -.
DR BioGRID; 128590; 39.
DR STRING; 9606.ENSP00000325203; -.
DR GlyGen; Q8NGN1; 1 site.
DR iPTMnet; Q8NGN1; -.
DR PhosphoSitePlus; Q8NGN1; -.
DR BioMuta; OR6T1; -.
DR DMDM; 38372731; -.
DR MassIVE; Q8NGN1; -.
DR PaxDb; Q8NGN1; -.
DR PeptideAtlas; Q8NGN1; -.
DR PRIDE; Q8NGN1; -.
DR ProteomicsDB; 73558; -.
DR Antibodypedia; 56776; 103 antibodies from 22 providers.
DR DNASU; 219874; -.
DR Ensembl; ENST00000321252.3; ENSP00000325203.2; ENSG00000181499.3.
DR GeneID; 219874; -.
DR KEGG; hsa:219874; -.
DR MANE-Select; ENST00000321252.3; ENSP00000325203.2; NM_001005187.1; NP_001005187.1.
DR UCSC; uc010sab.3; human.
DR CTD; 219874; -.
DR GeneCards; OR6T1; -.
DR HGNC; HGNC:14848; OR6T1.
DR HPA; ENSG00000181499; Not detected.
DR neXtProt; NX_Q8NGN1; -.
DR OpenTargets; ENSG00000181499; -.
DR PharmGKB; PA32605; -.
DR VEuPathDB; HostDB:ENSG00000181499; -.
DR eggNOG; ENOG502SH9P; Eukaryota.
DR GeneTree; ENSGT01050000244938; -.
DR HOGENOM; CLU_012526_1_1_1; -.
DR InParanoid; Q8NGN1; -.
DR OMA; MSPENWT; -.
DR OrthoDB; 1118884at2759; -.
DR PhylomeDB; Q8NGN1; -.
DR TreeFam; TF336833; -.
DR PathwayCommons; Q8NGN1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219874; 7 hits in 668 CRISPR screens.
DR GeneWiki; OR6T1; -.
DR GenomeRNAi; 219874; -.
DR Pharos; Q8NGN1; Tdark.
DR PRO; PR:Q8NGN1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGN1; protein.
DR Bgee; ENSG00000181499; Expressed in body of pancreas and 3 other tissues.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..323
FT /note="Olfactory receptor 6T1"
FT /id="PRO_0000150638"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..323
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 23
FT /note="I -> T (in dbSNP:rs6590022)"
FT /id="VAR_048049"
FT VARIANT 64
FT /note="R -> W (in dbSNP:rs6590021)"
FT /id="VAR_048050"
FT VARIANT 251
FT /note="I -> V (in dbSNP:rs7937317)"
FT /id="VAR_048051"
SQ SEQUENCE 323 AA; 36348 MW; 115EA0F3A5BE91E4 CRC64;
MNPENWTQVT SFVLLGFPSS HLIQFLVFLG LMVTYIVTAT GKLLIIVLSW IDQRLHIQMY
FFLRNFSFLE LLLVTVVVPK MLVVILTGDH TISFVSCIIQ SYLYFFLGTT DFFLLAVMSL
DRYLAICRPL RYETLMNGHV CSQLVLASWL AGFLWVLCPT VLMASLPFCG PNGIDHFFRD
SWPLLRLSCG DTHLLKLVAF MLSTLVLLGS LALTSVSYAC ILATVLRAPT AAERRKAFST
CASHLTVVVI IYGSSIFLYI RMSEAQSKLL NKGASVLSCI ITPLLNPFIF TLRNDKVQQA
LREALGWPRL TAVMKLRVTS QRK
