OR6X1_HUMAN
ID OR6X1_HUMAN Reviewed; 312 AA.
AC Q8NH79; B9EGW9; Q6IFA0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 6X1;
DE AltName: Full=Olfactory receptor OR11-270;
GN Name=OR6X1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6X1";
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DR EMBL; AB065510; BAC05758.1; -; Genomic_DNA.
DR EMBL; CH471065; EAW67555.1; -; Genomic_DNA.
DR EMBL; BC136855; AAI36856.1; -; mRNA.
DR EMBL; BC136856; AAI36857.1; -; mRNA.
DR EMBL; BK004362; DAA04760.1; -; Genomic_DNA.
DR CCDS; CCDS31695.1; -.
DR RefSeq; NP_001005188.1; NM_001005188.1.
DR AlphaFoldDB; Q8NH79; -.
DR SMR; Q8NH79; -.
DR BioGRID; 133476; 1.
DR IntAct; Q8NH79; 1.
DR STRING; 9606.ENSP00000333724; -.
DR GlyGen; Q8NH79; 1 site.
DR iPTMnet; Q8NH79; -.
DR PhosphoSitePlus; Q8NH79; -.
DR BioMuta; OR6X1; -.
DR DMDM; 38372825; -.
DR MassIVE; Q8NH79; -.
DR PaxDb; Q8NH79; -.
DR PeptideAtlas; Q8NH79; -.
DR PRIDE; Q8NH79; -.
DR Antibodypedia; 67317; 64 antibodies from 17 providers.
DR DNASU; 390260; -.
DR Ensembl; ENST00000327930.3; ENSP00000333724.2; ENSG00000221931.3.
DR GeneID; 390260; -.
DR KEGG; hsa:390260; -.
DR MANE-Select; ENST00000327930.3; ENSP00000333724.2; NM_001005188.1; NP_001005188.1.
DR UCSC; uc010rzy.3; human.
DR CTD; 390260; -.
DR GeneCards; OR6X1; -.
DR HGNC; HGNC:14737; OR6X1.
DR HPA; ENSG00000221931; Not detected.
DR neXtProt; NX_Q8NH79; -.
DR OpenTargets; ENSG00000221931; -.
DR PharmGKB; PA32609; -.
DR VEuPathDB; HostDB:ENSG00000221931; -.
DR eggNOG; ENOG502SIF0; Eukaryota.
DR GeneTree; ENSGT01050000244938; -.
DR HOGENOM; CLU_012526_1_1_1; -.
DR InParanoid; Q8NH79; -.
DR OMA; KAMTCPK; -.
DR OrthoDB; 1126810at2759; -.
DR PhylomeDB; Q8NH79; -.
DR TreeFam; TF337475; -.
DR PathwayCommons; Q8NH79; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NH79; -.
DR BioGRID-ORCS; 390260; 9 hits in 673 CRISPR screens.
DR GeneWiki; OR6X1; -.
DR GenomeRNAi; 390260; -.
DR Pharos; Q8NH79; Tdark.
DR PRO; PR:Q8NH79; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH79; protein.
DR ExpressionAtlas; Q8NH79; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 6X1"
FT /id="PRO_0000150640"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 190
FT /note="T -> N (in dbSNP:rs12364099)"
FT /id="VAR_024110"
SQ SEQUENCE 312 AA; 34727 MW; 4A4E176923A167A1 CRC64;
MRNGTVITEF ILLGFPVIQG LQTPLFIAIF LTYILTLAGN GLIIATVWAE PRLQIPMYFF
LCNLSFLEIW YTTTVIPKLL GTFVVARTVI CMSCCLLQAF FHFFVGTTEF LILTIMSFDR
YLTICNPLHH PTIMTSKLCL QLALSSWVVG FTIVFCQTML LIQLPFCGNN VISHFYCDVG
PSLKAACIDT SILELLGVIA TILVIPGSLL FNMISYIYIL SAILRIPSAT GHQKTFSTCA
SHLTVVSLLY GAVLFMYLRP TAHSSFKINK VVSVLNTILT PLLNPFIYTI RNKEVKGALR
KAMTCPKTGH AK
