OR6Y1_HUMAN
ID OR6Y1_HUMAN Reviewed; 325 AA.
AC Q8NGX8; Q6IFS0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Olfactory receptor 6Y1;
DE AltName: Full=Olfactory receptor 6Y2;
DE AltName: Full=Olfactory receptor OR1-11;
GN Name=OR6Y1; Synonyms=OR6Y2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6Y1";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065638; BAC05864.1; -; Genomic_DNA.
DR EMBL; AL365440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK004192; DAA04590.1; -; Genomic_DNA.
DR CCDS; CCDS30899.1; -.
DR RefSeq; NP_001005189.1; NM_001005189.1.
DR AlphaFoldDB; Q8NGX8; -.
DR SMR; Q8NGX8; -.
DR STRING; 9606.ENSP00000304807; -.
DR GlyGen; Q8NGX8; 2 sites.
DR iPTMnet; Q8NGX8; -.
DR PhosphoSitePlus; Q8NGX8; -.
DR BioMuta; OR6Y1; -.
DR DMDM; 38372783; -.
DR PaxDb; Q8NGX8; -.
DR PeptideAtlas; Q8NGX8; -.
DR PRIDE; Q8NGX8; -.
DR Antibodypedia; 64509; 7 antibodies from 7 providers.
DR DNASU; 391112; -.
DR Ensembl; ENST00000641282.1; ENSP00000493253.1; ENSG00000197532.3.
DR Ensembl; ENST00000641622.1; ENSP00000492894.1; ENSG00000197532.3.
DR GeneID; 391112; -.
DR KEGG; hsa:391112; -.
DR MANE-Select; ENST00000641622.1; ENSP00000492894.1; NM_001005189.2; NP_001005189.1.
DR UCSC; uc010pil.2; human.
DR CTD; 391112; -.
DR DisGeNET; 391112; -.
DR GeneCards; OR6Y1; -.
DR HGNC; HGNC:14823; OR6Y1.
DR HPA; ENSG00000197532; Tissue enhanced (brain, retina).
DR neXtProt; NX_Q8NGX8; -.
DR OpenTargets; ENSG00000197532; -.
DR PharmGKB; PA32610; -.
DR VEuPathDB; HostDB:ENSG00000197532; -.
DR eggNOG; ENOG502RIR8; Eukaryota.
DR GeneTree; ENSGT01050000244853; -.
DR HOGENOM; CLU_012526_0_0_1; -.
DR InParanoid; Q8NGX8; -.
DR OMA; RTVTTHF; -.
DR OrthoDB; 869383at2759; -.
DR PhylomeDB; Q8NGX8; -.
DR TreeFam; TF337475; -.
DR PathwayCommons; Q8NGX8; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 391112; 8 hits in 670 CRISPR screens.
DR GeneWiki; OR6Y1; -.
DR GenomeRNAi; 391112; -.
DR Pharos; Q8NGX8; Tdark.
DR PRO; PR:Q8NGX8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NGX8; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..325
FT /note="Olfactory receptor 6Y1"
FT /id="PRO_0000150641"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..325
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 191
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 102..194
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 104
FT /note="T -> I (in dbSNP:rs55665765)"
FT /id="VAR_062055"
SQ SEQUENCE 325 AA; 36636 MW; 3BECFEBD98AB6151 CRC64;
MTTIILEVDN HTVTTRFILL GFPTRPAFQL LFFSIFLATY LLTLLENLLI ILAIHSDGQL
HKPMYFFLSH LSFLEMWYVT VISPKMLVDF LSHDKSISFN GCMTQLYFFV TFVCTEYILL
AIMAFDRYVA ICNPLRYPVI MTNQLCGTLA GGCWFCGLMT AMIKMVFIAQ LHYCGMPQIN
HYFCDISPLL NVSCEDASQA EMVDFFLALM VIAIPLCVVV ASYAAILATI LRIPSAQGRQ
KAFSTCASHL TVVILFYSMT LFTYARPKLM YAYNSNKVVS VLYTVIVPLL NPIIYCLRNH
EVKAALRKTI HCRGSGPQGN GAFSS
