OR7AH_HUMAN
ID OR7AH_HUMAN Reviewed; 309 AA.
AC O14581; Q6IFQ6; Q96R98;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Olfactory receptor 7A17;
GN Name=OR7A17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- INTERACTION:
CC O14581; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-13329281, EBI-3867333;
CC O14581; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-13329281, EBI-1052037;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7A17";
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DR EMBL; AC002988; AAB82060.1; -; Genomic_DNA.
DR EMBL; BC101587; AAI01588.1; -; mRNA.
DR EMBL; BC117357; AAI17358.1; -; mRNA.
DR EMBL; AF399541; AAK95026.1; -; Genomic_DNA.
DR EMBL; BK004206; DAA04604.1; -; Genomic_DNA.
DR CCDS; CCDS12319.1; -.
DR RefSeq; NP_112163.1; NM_030901.1.
DR AlphaFoldDB; O14581; -.
DR SMR; O14581; -.
DR BioGRID; 117682; 5.
DR IntAct; O14581; 2.
DR STRING; 9606.ENSP00000328144; -.
DR GlyGen; O14581; 1 site.
DR iPTMnet; O14581; -.
DR PhosphoSitePlus; O14581; -.
DR BioMuta; OR7A17; -.
DR MassIVE; O14581; -.
DR PaxDb; O14581; -.
DR PRIDE; O14581; -.
DR Antibodypedia; 71928; 20 antibodies from 11 providers.
DR DNASU; 26333; -.
DR Ensembl; ENST00000641113.1; ENSP00000493283.1; ENSG00000185385.5.
DR Ensembl; ENST00000642123.1; ENSP00000493071.1; ENSG00000185385.5.
DR GeneID; 26333; -.
DR KEGG; hsa:26333; -.
DR MANE-Select; ENST00000641113.1; ENSP00000493283.1; NM_030901.2; NP_112163.1.
DR UCSC; uc010xob.3; human.
DR CTD; 26333; -.
DR GeneCards; OR7A17; -.
DR HGNC; HGNC:8363; OR7A17.
DR HPA; ENSG00000185385; Not detected.
DR neXtProt; NX_O14581; -.
DR OpenTargets; ENSG00000185385; -.
DR PharmGKB; PA32616; -.
DR VEuPathDB; HostDB:ENSG00000185385; -.
DR eggNOG; ENOG502RTYS; Eukaryota.
DR GeneTree; ENSGT00940000153523; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; O14581; -.
DR OMA; MKAGNET; -.
DR OrthoDB; 984499at2759; -.
DR PhylomeDB; O14581; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; O14581; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; O14581; -.
DR BioGRID-ORCS; 26333; 227 hits in 623 CRISPR screens.
DR GeneWiki; OR7A17; -.
DR GenomeRNAi; 26333; -.
DR Pharos; O14581; Tdark.
DR PRO; PR:O14581; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O14581; protein.
DR Bgee; ENSG00000185385; Expressed in sural nerve.
DR ExpressionAtlas; O14581; baseline and differential.
DR Genevisible; O14581; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Olfactory receptor 7A17"
FT /id="PRO_0000150645"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 37
FT /note="V -> A (in dbSNP:rs10405148)"
FT /id="VAR_053228"
FT VARIANT 46
FT /note="I -> T (in dbSNP:rs10405129)"
FT /id="VAR_053229"
FT VARIANT 69
FT /note="A -> S (in dbSNP:rs10404119)"
FT /id="VAR_053230"
FT VARIANT 237
FT /note="A -> T (in dbSNP:rs13345394)"
FT /id="VAR_053231"
SQ SEQUENCE 309 AA; 34013 MW; 7D3CED8A480C13D0 CRC64;
MEPENDTGIS EFVLLGLSEE PELQPFLFGL FLSMYLVTVL GNLLIILATI SDSHLHTPMY
FFLSNLSFAD ICFISTTIPK MLINIQTQSR VITYAGCITQ MCFFVLFGGL DSLLLAVMAY
DRFVAICHPL HYTVIMNPRL CGLLVLASWM IAALNSLSQS LMVLWLSFCT DLEIPHFFCE
LNQVIHLACS DTFLNDMGMY FAAGLLAGGP LVGILCSYSK IVSSIRAISS AQGKYKAFST
CASHLSVVSL FCCTGLGVYL TSAATHNSHT SATASVMYTV ATPMLNPFIY SLRNKDIKRA
LKMSFRGKQ
