OR7C1_HUMAN
ID OR7C1_HUMAN Reviewed; 320 AA.
AC O76099; Q15621; Q6IFP2; Q96R94;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 177.
DE RecName: Full=Olfactory receptor 7C1;
DE AltName: Full=Olfactory receptor 7C4;
DE AltName: Full=Olfactory receptor OR19-16;
DE AltName: Full=Olfactory receptor TPCR86;
GN Name=OR7C1; Synonyms=OR7C4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283, AND VARIANT LYS-171.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 126-282, AND VARIANTS LYS-171 AND PRO-210.
RC TISSUE=Testis;
RX PubMed=9119360; DOI=10.1006/geno.1996.4490;
RA Vanderhaeghen P., Schurmans S., Vassart G., Parmentier M.;
RT "Specific repertoire of olfactory receptor genes in the male germ cells of
RT several mammalian species.";
RL Genomics 39:239-246(1997).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7C1";
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DR EMBL; AC005255; AAC25625.1; -; Genomic_DNA.
DR EMBL; AF399546; AAK95031.1; -; Genomic_DNA.
DR EMBL; X89676; CAA61823.1; -; mRNA.
DR EMBL; BK004220; DAA04618.1; -; Genomic_DNA.
DR CCDS; CCDS12317.1; -.
DR PIR; S58004; S58004.
DR RefSeq; NP_945182.1; NM_198944.1.
DR RefSeq; XP_005259910.1; XM_005259853.3.
DR AlphaFoldDB; O76099; -.
DR SMR; O76099; -.
DR BioGRID; 117779; 3.
DR IntAct; O76099; 1.
DR STRING; 9606.ENSP00000248073; -.
DR GlyGen; O76099; 1 site.
DR iPTMnet; O76099; -.
DR PhosphoSitePlus; O76099; -.
DR BioMuta; OR7C1; -.
DR MassIVE; O76099; -.
DR PaxDb; O76099; -.
DR PRIDE; O76099; -.
DR Antibodypedia; 59279; 51 antibodies from 18 providers.
DR DNASU; 26664; -.
DR Ensembl; ENST00000248073.2; ENSP00000248073.2; ENSG00000127530.4.
DR Ensembl; ENST00000641666.1; ENSP00000493429.1; ENSG00000127530.4.
DR Ensembl; ENST00000642000.1; ENSP00000493248.1; ENSG00000127530.4.
DR Ensembl; ENST00000642030.1; ENSP00000493026.1; ENSG00000127530.4.
DR GeneID; 26664; -.
DR KEGG; hsa:26664; -.
DR MANE-Select; ENST00000641666.2; ENSP00000493429.1; NM_001370485.4; NP_001357414.2.
DR UCSC; uc010xnz.3; human.
DR CTD; 26664; -.
DR DisGeNET; 26664; -.
DR GeneCards; OR7C1; -.
DR HGNC; HGNC:8373; OR7C1.
DR HPA; ENSG00000127530; Tissue enhanced (parathyroid).
DR neXtProt; NX_O76099; -.
DR OpenTargets; ENSG00000127530; -.
DR PharmGKB; PA32624; -.
DR VEuPathDB; HostDB:ENSG00000127530; -.
DR eggNOG; ENOG502T9M8; Eukaryota.
DR GeneTree; ENSGT00940000162084; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; O76099; -.
DR OMA; FCTKMEI; -.
DR OrthoDB; 1045551at2759; -.
DR PhylomeDB; O76099; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; O76099; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; O76099; -.
DR BioGRID-ORCS; 26664; 7 hits in 670 CRISPR screens.
DR ChiTaRS; OR7C1; human.
DR GeneWiki; OR7C1; -.
DR GenomeRNAi; 26664; -.
DR Pharos; O76099; Tdark.
DR PRO; PR:O76099; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O76099; protein.
DR Bgee; ENSG00000127530; Expressed in adrenal tissue and 81 other tissues.
DR ExpressionAtlas; O76099; baseline and differential.
DR Genevisible; O76099; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:ProtInc.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; TAS:ProtInc.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..320
FT /note="Olfactory receptor 7C1"
FT /id="PRO_0000150646"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 99
FT /note="S -> G (in dbSNP:rs17230134)"
FT /id="VAR_053232"
FT VARIANT 126
FT /note="V -> I (in dbSNP:rs10415562)"
FT /id="VAR_024111"
FT VARIANT 171
FT /note="E -> K (in dbSNP:rs10415312)"
FT /evidence="ECO:0000269|PubMed:12213199,
FT ECO:0000269|PubMed:9119360"
FT /id="VAR_053233"
FT VARIANT 210
FT /note="S -> P (in dbSNP:rs16979912)"
FT /evidence="ECO:0000269|PubMed:9119360"
FT /id="VAR_024112"
FT CONFLICT 247
FT /note="V -> L (in Ref. 3; CAA61823)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 320 AA; 35519 MW; BBDCC409721D70C4 CRC64;
METGNQTHAQ EFLLLGFSAT SEIQFILFGL FLSMYLVTFT GNLLIILAIC SDSHLHTPMY
FFLSNLSFAD LCFTSTTVPK MLLNILTQNK FITYAGCLSQ IFFFTSFGCL DNLLLTVMAY
DRFVAVCHPL HYTVIMNPQL CGLLVLGSWC ISVMGSLLET LTVLRLSFCT EMEIPHFFCD
LLEVLKLACS DTFINNVVIY FATGVLGVIS FTGIFFSYYK IVFSILRISS AGRKHKAFST
CGSHLSVVTL FYGTGFGVYL SSAATPSSRT SLVASVMYTM VTPMLNPFIY SLRNTDMKRA
LGRLLSRATF FNGDITAGLS
