OR7C2_HUMAN
ID OR7C2_HUMAN Reviewed; 319 AA.
AC O60412; O43881; Q6IFP9;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 4.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Olfactory receptor 7C2;
DE AltName: Full=Olfactory receptor 19-18;
DE Short=OR19-18;
DE AltName: Full=Olfactory receptor 7C3;
DE AltName: Full=Olfactory receptor OR19-22;
GN Name=OR7C2; Synonyms=OR7C3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX PubMed=9500546; DOI=10.1038/ng0398-243;
RA Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G.,
RA Demaille J.G., Giorgi D.;
RT "Distribution of olfactory receptor genes in the human genome.";
RL Nat. Genet. 18:243-250(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- INTERACTION:
CC O60412; P63167: DYNLL1; NbExp=3; IntAct=EBI-12173063, EBI-349105;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04611.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7C2";
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DR EMBL; AC004659; AAC15755.1; -; Genomic_DNA.
DR EMBL; U86255; AAC39626.1; -; Genomic_DNA.
DR EMBL; AF399545; AAK95030.1; -; Genomic_DNA.
DR EMBL; BK004213; DAA04611.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS12320.1; -.
DR RefSeq; NP_036509.1; NM_012377.1.
DR AlphaFoldDB; O60412; -.
DR SMR; O60412; -.
DR BioGRID; 117776; 2.
DR IntAct; O60412; 1.
DR STRING; 9606.ENSP00000248072; -.
DR GlyGen; O60412; 1 site.
DR BioMuta; OR7C2; -.
DR MassIVE; O60412; -.
DR PaxDb; O60412; -.
DR PeptideAtlas; O60412; -.
DR PRIDE; O60412; -.
DR Antibodypedia; 59285; 49 antibodies from 17 providers.
DR DNASU; 26658; -.
DR Ensembl; ENST00000248072.3; ENSP00000248072.3; ENSG00000127529.7.
DR GeneID; 26658; -.
DR KEGG; hsa:26658; -.
DR MANE-Select; ENST00000248072.3; ENSP00000248072.3; NM_012377.1; NP_036509.1.
DR UCSC; uc010xoc.2; human.
DR CTD; 26658; -.
DR GeneCards; OR7C2; -.
DR HGNC; HGNC:8374; OR7C2.
DR HPA; ENSG00000127529; Not detected.
DR neXtProt; NX_O60412; -.
DR PharmGKB; PA32625; -.
DR VEuPathDB; HostDB:ENSG00000127529; -.
DR eggNOG; ENOG502T9M8; Eukaryota.
DR GeneTree; ENSGT00940000162084; -.
DR HOGENOM; CLU_012526_1_3_1; -.
DR InParanoid; O60412; -.
DR OMA; FFIAFGC; -.
DR OrthoDB; 1045551at2759; -.
DR PhylomeDB; O60412; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; O60412; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; O60412; -.
DR BioGRID-ORCS; 26658; 9 hits in 668 CRISPR screens.
DR GeneWiki; OR7C2; -.
DR GenomeRNAi; 26658; -.
DR Pharos; O60412; Tdark.
DR PRO; PR:O60412; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O60412; protein.
DR Bgee; ENSG00000127529; Expressed in sural nerve.
DR Genevisible; O60412; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..319
FT /note="Olfactory receptor 7C2"
FT /id="PRO_0000150647"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 118
FT /note="T -> M (in dbSNP:rs8113325)"
FT /id="VAR_027808"
FT VARIANT 122
FT /note="R -> H (in dbSNP:rs11883178)"
FT /id="VAR_053234"
FT CONFLICT 168
FT /note="F -> S (in Ref. 2; AAC39626 and 3; AAK95030)"
FT /evidence="ECO:0000305"
FT CONFLICT 200
FT /note="Y -> C (in Ref. 2; AAC39626 and 3; AAK95030)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="S -> SS (in Ref. 2; AAC39626 and 3; AAK95030)"
FT /evidence="ECO:0000305"
FT CONFLICT 238
FT /note="S -> T (in Ref. 2; AAC39626 and 3; AAK95030)"
FT /evidence="ECO:0000305"
FT CONFLICT 277
FT /note="Y -> H (in Ref. 2; AAC39626 and 3; AAK95030)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 319 AA; 35323 MW; 1FAF5A196B2B566C CRC64;
MERGNQTEVG NFLLLGFAED SDMQLLLHGL FLSMYLVTII GNLLIILTIS SDSHLHTPMY
FFLSNLSFAD ICFTSTTVPK MLVNIQTQSK MITFAGCLTQ IFFFIAFGCL DNLLLTMTAY
DRFVAICYPL HYTVIMNPRL CGLLVLGSWC ISVMGSLLET LTILRLSFCT NMEIPHFFCD
PSEVLKLACS DTFINNIVMY FVTIVLGVFP LCGILFSYSQ IFSSVLRVSA RGQHKAFSTC
GSHLSVVSLF YGTGLGVYLS SAVTPPSRTS LAASVMYTMV TPMLNPFIYS LRNKDMKGSL
GRLLLRATSL KEGTIAKLS
