OR7D2_HUMAN
ID OR7D2_HUMAN Reviewed; 312 AA.
AC Q96RA2; Q6IFJ7; Q8N133;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 26-SEP-2003, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Olfactory receptor 7D2;
DE AltName: Full=HTPCRH03;
DE AltName: Full=Olfactory receptor 19-4;
DE Short=OR19-4;
DE AltName: Full=Olfactory receptor OR19-10;
GN Name=OR7D2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- INTERACTION:
CC Q96RA2; Q9HAT8: PELI2; NbExp=3; IntAct=EBI-12826231, EBI-448407;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7D2";
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DR EMBL; AB065928; BAC06143.1; -; Genomic_DNA.
DR EMBL; AK095468; BAC04554.1; -; mRNA.
DR EMBL; AF399537; AAK95022.1; -; Genomic_DNA.
DR EMBL; BK004265; DAA04663.1; -; Genomic_DNA.
DR CCDS; CCDS32900.1; -.
DR RefSeq; NP_787079.1; NM_175883.2.
DR AlphaFoldDB; Q96RA2; -.
DR SMR; Q96RA2; -.
DR BioGRID; 127840; 57.
DR IntAct; Q96RA2; 1.
DR STRING; 9606.ENSP00000345563; -.
DR GlyGen; Q96RA2; 1 site.
DR iPTMnet; Q96RA2; -.
DR PhosphoSitePlus; Q96RA2; -.
DR BioMuta; OR7D2; -.
DR DMDM; 37081386; -.
DR MassIVE; Q96RA2; -.
DR PaxDb; Q96RA2; -.
DR PRIDE; Q96RA2; -.
DR Antibodypedia; 76442; 6 antibodies from 6 providers.
DR DNASU; 162998; -.
DR Ensembl; ENST00000344248.4; ENSP00000345563.2; ENSG00000188000.6.
DR Ensembl; ENST00000641288.2; ENSP00000493200.1; ENSG00000188000.6.
DR Ensembl; ENST00000642043.1; ENSP00000492939.1; ENSG00000188000.6.
DR GeneID; 162998; -.
DR KEGG; hsa:162998; -.
DR MANE-Select; ENST00000641288.2; ENSP00000493200.1; NM_175883.4; NP_787079.1.
DR UCSC; uc002mkz.1; human.
DR CTD; 162998; -.
DR GeneCards; OR7D2; -.
DR HGNC; HGNC:8378; OR7D2.
DR HPA; ENSG00000188000; Low tissue specificity.
DR neXtProt; NX_Q96RA2; -.
DR OpenTargets; ENSG00000188000; -.
DR PharmGKB; PA32627; -.
DR VEuPathDB; HostDB:ENSG00000188000; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT00940000164306; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q96RA2; -.
DR OMA; FFCELTH; -.
DR OrthoDB; 861950at2759; -.
DR PhylomeDB; Q96RA2; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q96RA2; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q96RA2; -.
DR BioGRID-ORCS; 162998; 14 hits in 678 CRISPR screens.
DR ChiTaRS; OR7D2; human.
DR GeneWiki; OR7D2; -.
DR GenomeRNAi; 162998; -.
DR Pharos; Q96RA2; Tdark.
DR PRO; PR:Q96RA2; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96RA2; protein.
DR Bgee; ENSG00000188000; Expressed in skin of hip and 115 other tissues.
DR Genevisible; Q96RA2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 7D2"
FT /id="PRO_0000150648"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 197
FT /note="T -> M (in dbSNP:rs13345452)"
FT /id="VAR_053235"
SQ SEQUENCE 312 AA; 34747 MW; 4EB05A7BA9BBB0F5 CRC64;
MEAGNQTGFL EFILLGLSED PELQPFIFGL FLSMYLVTVL GNLLIILAIS SDSHLHTPMY
FFLSNLSWVD ICFSTCIVPK MLVNIQTENK AISYMDCLTQ VYFSMFFPIL DTLLLTVMAY
DRFVAVCHPL HYMIIMNPHL CGLLVFVTWL IGVMTSLLHI SLMMHLIFCK DFEIPHFFCE
LTYILQLACS DTFLNSTLIY FMTGVLGVFP LLGIIFSYSR IASSIRKMSS SGGKQKALST
CGSHLSVVSL FYGTGIGVHF TSAVTHSSQK ISVASVMYTV VTPMLNPFIY SLRNKDVKGA
LGSLLSRAAS CL
