OR7D4_HUMAN
ID OR7D4_HUMAN Reviewed; 312 AA.
AC Q8NG98; A8CAH8; A8CAH9; A8CAI0; A8CAI1; B9EH79;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Olfactory receptor 7D4;
DE AltName: Full=OR19-B;
DE AltName: Full=Odorant receptor family subfamily D member 4RT;
DE AltName: Full=Olfactory receptor OR19-7;
GN Name=OR7D4; Synonyms=OR7D4P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLY-52; CYS-75; LEU-79;
RP ASN-84; TRP-88; GLN-131; MET-133; ILE-136; ARG-139; TYR-139; PRO-162;
RP ASP-279 AND MET-292.
RX PubMed=17873857; DOI=10.1038/nature06162;
RA Keller A., Zhuang H., Chi Q., Vosshall L.B., Matsunami H.;
RT "Genetic variation in a human odorant receptor alters odour perception.";
RL Nature 449:468-472(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=17509148; DOI=10.1186/gb-2007-8-5-r86;
RA Zhang X., De la Cruz O., Pinto J.M., Nicolae D., Firestein S., Gilad Y.;
RT "Characterizing the expression of the human olfactory receptor gene family
RT using a novel DNA microarray.";
RL Genome Biol. 8:R86.1-R86.10(2007).
CC -!- FUNCTION: Odorant receptor. Selectively activated by androstenone and
CC the related odorous steroid androstadienone.
CC -!- INTERACTION:
CC Q8NG98; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-18164026, EBI-18159983;
CC Q8NG98; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-18164026, EBI-11988865;
CC Q8NG98; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-18164026, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Nasal olfactory epithelium.
CC {ECO:0000269|PubMed:17509148}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7D4";
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=The selfish smell - Issue 94
CC of May 2008;
CC URL="https://web.expasy.org/spotlight/back_issues/094";
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DR EMBL; EU049291; ABV66282.1; -; Genomic_DNA.
DR EMBL; EU049292; ABV66283.1; -; Genomic_DNA.
DR EMBL; EU049293; ABV66284.1; -; Genomic_DNA.
DR EMBL; EU049294; ABV66285.1; -; Genomic_DNA.
DR EMBL; AB065929; BAC06144.1; -; Genomic_DNA.
DR EMBL; CH471106; EAW84021.1; -; Genomic_DNA.
DR EMBL; BC137147; AAI37148.1; -; mRNA.
DR EMBL; BC137162; AAI37163.1; -; mRNA.
DR EMBL; BK004226; DAA04624.1; -; Genomic_DNA.
DR CCDS; CCDS32901.1; -.
DR RefSeq; NP_001005191.1; NM_001005191.2.
DR AlphaFoldDB; Q8NG98; -.
DR SMR; Q8NG98; -.
DR BioGRID; 125937; 3.
DR IntAct; Q8NG98; 3.
DR STRING; 9606.ENSP00000310488; -.
DR GlyGen; Q8NG98; 1 site.
DR BioMuta; OR7D4; -.
DR DMDM; 71153032; -.
DR MassIVE; Q8NG98; -.
DR PaxDb; Q8NG98; -.
DR PeptideAtlas; Q8NG98; -.
DR PRIDE; Q8NG98; -.
DR Antibodypedia; 42767; 47 antibodies from 20 providers.
DR DNASU; 125958; -.
DR Ensembl; ENST00000308682.3; ENSP00000310488.2; ENSG00000174667.4.
DR Ensembl; ENST00000641244.1; ENSP00000493404.1; ENSG00000174667.4.
DR Ensembl; ENST00000641669.1; ENSP00000493383.1; ENSG00000174667.4.
DR GeneID; 125958; -.
DR KEGG; hsa:125958; -.
DR MANE-Select; ENST00000641669.1; ENSP00000493383.1; NM_001005191.3; NP_001005191.1.
DR UCSC; uc002mla.2; human.
DR CTD; 125958; -.
DR DisGeNET; 125958; -.
DR GeneCards; OR7D4; -.
DR HGNC; HGNC:8380; OR7D4.
DR HPA; ENSG00000174667; Not detected.
DR MIM; 611538; gene.
DR neXtProt; NX_Q8NG98; -.
DR OpenTargets; ENSG00000174667; -.
DR PharmGKB; PA32628; -.
DR VEuPathDB; HostDB:ENSG00000174667; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT00940000153686; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NG98; -.
DR OMA; NNICLYV; -.
DR OrthoDB; 995191at2759; -.
DR PhylomeDB; Q8NG98; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q8NG98; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NG98; -.
DR BioGRID-ORCS; 125958; 197 hits in 622 CRISPR screens.
DR GeneWiki; OR7D4; -.
DR GenomeRNAi; 125958; -.
DR Pharos; Q8NG98; Tbio.
DR PRO; PR:Q8NG98; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NG98; protein.
DR Bgee; ENSG00000174667; Expressed in ganglionic eminence and 1 other tissue.
DR ExpressionAtlas; Q8NG98; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 7D4"
FT /id="PRO_0000150649"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 17
FT /note="L -> F (in dbSNP:rs57568862)"
FT /id="VAR_062056"
FT VARIANT 52
FT /note="D -> G (in dbSNP:rs144165121)"
FT /evidence="ECO:0000269|PubMed:17873857"
FT /id="VAR_037778"
FT VARIANT 75
FT /note="S -> C (in dbSNP:rs778417216)"
FT /evidence="ECO:0000269|PubMed:17873857"
FT /id="VAR_037779"
FT VARIANT 79
FT /note="P -> L (impaired response to androstenone and
FT androstadienone; dbSNP:rs61732668)"
FT /evidence="ECO:0000269|PubMed:17873857"
FT /id="VAR_037780"
FT VARIANT 84
FT /note="S -> N (high sensitivity to androstenone and
FT androstadienone; dbSNP:rs5020280)"
FT /evidence="ECO:0000269|PubMed:17873857"
FT /id="VAR_037781"
FT VARIANT 88
FT /note="R -> W (impaired response to androstenone and
FT androstadienone; when associated with M-133;
FT dbSNP:rs61729907)"
FT /evidence="ECO:0000269|PubMed:17873857"
FT /id="VAR_037782"
FT VARIANT 131
FT /note="H -> Q (in dbSNP:rs748899150)"
FT /evidence="ECO:0000269|PubMed:17873857"
FT /id="VAR_037783"
FT VARIANT 133
FT /note="T -> M (impaired response to androstenone and
FT androstadienone; when associated with W-88;
FT dbSNP:rs5020278)"
FT /evidence="ECO:0000269|PubMed:17873857"
FT /id="VAR_037784"
FT VARIANT 136
FT /note="M -> I (in dbSNP:rs5020277)"
FT /evidence="ECO:0000269|PubMed:17873857"
FT /id="VAR_037785"
FT VARIANT 139
FT /note="C -> R (in dbSNP:rs1310684516)"
FT /evidence="ECO:0000269|PubMed:17873857"
FT /id="VAR_037786"
FT VARIANT 139
FT /note="C -> Y (in dbSNP:rs1205320769)"
FT /evidence="ECO:0000269|PubMed:17873857"
FT /id="VAR_037787"
FT VARIANT 162
FT /note="L -> P (in dbSNP:rs1321662937)"
FT /evidence="ECO:0000269|PubMed:17873857"
FT /id="VAR_037788"
FT VARIANT 279
FT /note="A -> D (in dbSNP:rs138510982)"
FT /evidence="ECO:0000269|PubMed:17873857"
FT /id="VAR_037789"
FT VARIANT 292
FT /note="L -> M (in dbSNP:rs4564704)"
FT /evidence="ECO:0000269|PubMed:17873857"
FT /id="VAR_037790"
SQ SEQUENCE 312 AA; 34448 MW; FD97DD41B890B085 CRC64;
MEAENLTELS KFLLLGLSDD PELQPVLFGL FLSMYLVTVL GNLLIILAVS SDSHLHTPMY
FFLSNLSFVD ICFISTTVPK MLVSIQARSK DISYMGCLTQ VYFLMMFAGM DTFLLAVMAY
DRFVAICHPL HYTVIMNPCL CGLLVLASWF IIFWFSLVHI LLMKRLTFST GTEIPHFFCE
PAQVLKVACS NTLLNNIVLY VATALLGVFP VAGILFSYSQ IVSSLMGMSS TKGKYKAFST
CGSHLCVVSL FYGTGLGVYL SSAVTHSSQS SSTASVMYAM VTPMLNPFIY SLRNKDVKGA
LERLLSRADS CP
