OR7G1_HUMAN
ID OR7G1_HUMAN Reviewed; 311 AA.
AC Q8NGA0; Q6IFJ5; Q96RA1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Olfactory receptor 7G1;
DE AltName: Full=Olfactory receptor 19-15;
DE Short=OR19-15;
DE AltName: Full=Olfactory receptor OR19-8;
GN Name=OR7G1; Synonyms=OR7G1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC06141.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7G1";
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DR EMBL; AB065926; BAC06141.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC011464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF399538; AAK95023.1; -; Genomic_DNA.
DR EMBL; BK004267; DAA04665.1; -; Genomic_DNA.
DR CCDS; CCDS32898.2; -.
DR RefSeq; NP_001005192.2; NM_001005192.2.
DR AlphaFoldDB; Q8NGA0; -.
DR SMR; Q8NGA0; -.
DR BioGRID; 125938; 1.
DR IntAct; Q8NGA0; 1.
DR MINT; Q8NGA0; -.
DR STRING; 9606.ENSP00000444134; -.
DR GlyGen; Q8NGA0; 2 sites.
DR BioMuta; OR7G1; -.
DR DMDM; 218511731; -.
DR MassIVE; Q8NGA0; -.
DR PaxDb; Q8NGA0; -.
DR PRIDE; Q8NGA0; -.
DR ProteomicsDB; 73458; -.
DR Antibodypedia; 56336; 66 antibodies from 13 providers.
DR DNASU; 125962; -.
DR Ensembl; ENST00000541538.1; ENSP00000444134.1; ENSG00000161807.3.
DR GeneID; 125962; -.
DR KEGG; hsa:125962; -.
DR MANE-Select; ENST00000541538.1; ENSP00000444134.1; NM_001005192.2; NP_001005192.2.
DR UCSC; uc021uoi.1; human.
DR CTD; 125962; -.
DR GeneCards; OR7G1; -.
DR HGNC; HGNC:8465; OR7G1.
DR HPA; ENSG00000161807; Not detected.
DR neXtProt; NX_Q8NGA0; -.
DR PharmGKB; PA32737; -.
DR VEuPathDB; HostDB:ENSG00000161807; -.
DR eggNOG; ENOG502T9M5; Eukaryota.
DR GeneTree; ENSGT00940000154619; -.
DR HOGENOM; CLU_012526_1_3_1; -.
DR InParanoid; Q8NGA0; -.
DR OMA; AGLESCF; -.
DR OrthoDB; 973307at2759; -.
DR PhylomeDB; Q8NGA0; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q8NGA0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGA0; -.
DR BioGRID-ORCS; 125962; 7 hits in 633 CRISPR screens.
DR GeneWiki; OR7G1; -.
DR GenomeRNAi; 125962; -.
DR Pharos; Q8NGA0; Tdark.
DR PRO; PR:Q8NGA0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NGA0; protein.
DR ExpressionAtlas; Q8NGA0; differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 7G1"
FT /id="PRO_0000150650"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 89
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 83
FT /note="V -> A (in dbSNP:rs6511874)"
FT /id="VAR_048074"
FT VARIANT 141
FT /note="W -> C (in dbSNP:rs2217657)"
FT /id="VAR_034255"
FT VARIANT 156
FT /note="A -> V (in dbSNP:rs7246980)"
FT /id="VAR_048075"
FT VARIANT 167
FT /note="S -> F (in dbSNP:rs7246969)"
FT /id="VAR_048076"
FT VARIANT 252
FT /note="Y -> C (in dbSNP:rs2195951)"
FT /id="VAR_034256"
SQ SEQUENCE 311 AA; 34803 MW; C408FFF590A95340 CRC64;
MGPRNQTAVS EFLLMKVTED PELKLIPFSL FLSMYLVTIL GNLLILLAVI SDSHLHTPMY
FLLFNLSFTD ICLTTTTVPK ILVNIQAQNQ SITYTGCLTQ ICLVLVFAGL ESCFLAVMAY
DRYVAICHPL RYTVLMNVHF WGLLILLSMF MSTMDALVQS LMVLQLSFCK NVEIPLFFCE
VVQVIKLACS DTLINNILIY FASSVFGAIP LSGIIFSYSQ IVTSVLRMPS ARGKYKAFST
CGCHLSVFSL FYGTAFGVYI SSAVAESSRI TAVASVMYTV VPQMMNPFIY SLRNKEMKKA
LRKLIGRLFP F
