OR7G2_HUMAN
ID OR7G2_HUMAN Reviewed; 324 AA.
AC Q8NG99; Q6IFJ4; Q96RA0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Olfactory receptor 7G2;
DE AltName: Full=OST260;
DE AltName: Full=Olfactory receptor 19-13;
DE Short=OR19-13;
DE AltName: Full=Olfactory receptor OR19-6;
GN Name=OR7G2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=DAA04666.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7G2";
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DR EMBL; AB065927; BAC06142.1; -; Genomic_DNA.
DR EMBL; AC011464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF399539; AAK95024.1; -; Genomic_DNA.
DR EMBL; BK004268; DAA04666.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS32897.1; -.
DR RefSeq; NP_001005193.1; NM_001005193.1.
DR AlphaFoldDB; Q8NG99; -.
DR SMR; Q8NG99; -.
DR STRING; 9606.ENSP00000303822; -.
DR GlyGen; Q8NG99; 2 sites.
DR BioMuta; OR7G2; -.
DR DMDM; 38372649; -.
DR MassIVE; Q8NG99; -.
DR PaxDb; Q8NG99; -.
DR PeptideAtlas; Q8NG99; -.
DR PRIDE; Q8NG99; -.
DR ProteomicsDB; 73457; -.
DR Antibodypedia; 68411; 69 antibodies from 18 providers.
DR DNASU; 390882; -.
DR Ensembl; ENST00000641081.1; ENSP00000492896.1; ENSG00000170923.4.
DR GeneID; 390882; -.
DR KEGG; hsa:390882; -.
DR MANE-Select; ENST00000641081.1; ENSP00000492896.1; NM_001005193.2; NP_001005193.2.
DR UCSC; uc010xkk.2; human.
DR CTD; 390882; -.
DR GeneCards; OR7G2; -.
DR HGNC; HGNC:8466; OR7G2.
DR HPA; ENSG00000170923; Not detected.
DR neXtProt; NX_Q8NG99; -.
DR VEuPathDB; HostDB:ENSG00000170923; -.
DR eggNOG; ENOG502T9M5; Eukaryota.
DR GeneTree; ENSGT00940000154131; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NG99; -.
DR OrthoDB; 973307at2759; -.
DR PhylomeDB; Q8NG99; -.
DR TreeFam; TF337210; -.
DR PathwayCommons; Q8NG99; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390882; 28 hits in 662 CRISPR screens.
DR ChiTaRS; OR7G2; human.
DR GeneWiki; OR7G2; -.
DR GenomeRNAi; 390882; -.
DR Pharos; Q8NG99; Tdark.
DR PRO; PR:Q8NG99; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NG99; protein.
DR Bgee; ENSG00000170923; Expressed in popliteal artery and 1 other tissue.
DR ExpressionAtlas; Q8NG99; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..324
FT /note="Olfactory receptor 7G2"
FT /id="PRO_0000150651"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..324
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 89
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 281
FT /note="F -> V (in dbSNP:rs4804401)"
FT /id="VAR_024113"
FT CONFLICT 271
FT /note="T -> A (in Ref. 3; AAK95024)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 324 AA; 35931 MW; C08808B72ABE34FC CRC64;
MEARNQTAIS KFLLLGLIED PELQPVLFSL FLSMYLVTIL GNLLILLAVI SDSHLHTPMY
FFLSNLSFLD ICLSTTTIPK MLVNIQAQNR SITYSGCLTQ ICFVLFFAGL ENCLLAAMAY
DRYVAICHPL RYTVIMNPRL CGLLILLSLL TSVVNALLLS LMVLRLSFCT DLEIPLFFCE
LAQVIQLTCS DTLINNILIY FAACIFGGVP LSGIILSYTQ ITSCVLRMPS ASGKHKAVST
CGSHLSIVLL FYGAGLGVYI SSVVTDSPRK TAVASVMYSV FPQMVNPFIY SLRNKDMKGT
LRKFIGRIPS LLWCAICFGF RFLE
