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OR82A_DROME
ID   OR82A_DROME             Reviewed;         385 AA.
AC   P82986;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Odorant receptor 82a;
GN   Name=Or82a; ORFNames=CG31519;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=10943836; DOI=10.1016/s0092-8674(00)00021-0;
RA   Vosshall L.B., Wong A.M., Axel R.;
RT   "An olfactory sensory map in the fly brain.";
RL   Cell 102:147-159(2000).
RN   [4]
RP   FUNCTION.
RX   PubMed=16615896; DOI=10.1016/j.cell.2006.01.050;
RA   Hallem E.A., Carlson J.R.;
RT   "Coding of odors by a receptor repertoire.";
RL   Cell 125:143-160(2006).
RN   [5]
RP   FUNCTION.
RX   PubMed=21613503; DOI=10.1523/jneurosci.6254-10.2011;
RA   Montague S.A., Mathew D., Carlson J.R.;
RT   "Similar odorants elicit different behavioral and physiological responses,
RT   some supersustained.";
RL   J. Neurosci. 31:7891-7899(2011).
CC   -!- FUNCTION: Odorant receptor which mediates acceptance or avoidance
CC       behavior, depending on its substrates. The odorant receptor repertoire
CC       encodes a large collection of odor stimuli that vary widely in
CC       identity, intensity, and duration. May form a complex with Orco to form
CC       odorant-sensing units, providing sensitive and prolonged odorant
CC       signaling and calcium permeability. {ECO:0000269|PubMed:16615896,
CC       ECO:0000269|PubMed:21613503}.
CC   -!- SUBUNIT: Interacts with Orco. Complexes exist early in the endomembrane
CC       system in olfactory sensory neurons (OSNs), coupling these complexes to
CC       the conserved ciliary trafficking pathway (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in olfactory sensory neurons in the
CC       antenna. {ECO:0000269|PubMed:10943836}.
CC   -!- MISCELLANEOUS: The atypical heteromeric and topological design of the
CC       odorant receptors appears to be an insect-specific solution for odor
CC       recognition, making the OR/Orco complex an attractive target for the
CC       development of highly selective insect repellents to disrupt olfactory-
CC       mediated host-seeking behaviors of insect disease vectors. Odor-evoked
CC       OR currents are independent of known G-protein-coupled second messenger
CC       pathways.
CC   -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
CC       Heteromeric odorant receptor channel (TC 1.A.69) family. Or1a
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AE014297; AAN13335.1; -; Genomic_DNA.
DR   RefSeq; NP_730794.1; NM_164323.1.
DR   AlphaFoldDB; P82986; -.
DR   SMR; P82986; -.
DR   STRING; 7227.FBpp0078616; -.
DR   PaxDb; P82986; -.
DR   EnsemblMetazoa; FBtr0078977; FBpp0078616; FBgn0041621.
DR   GeneID; 318778; -.
DR   KEGG; dme:Dmel_CG31519; -.
DR   CTD; 318778; -.
DR   FlyBase; FBgn0041621; Or82a.
DR   VEuPathDB; VectorBase:FBgn0041621; -.
DR   eggNOG; ENOG502SSPN; Eukaryota.
DR   GeneTree; ENSGT00940000168837; -.
DR   HOGENOM; CLU_033399_7_1_1; -.
DR   InParanoid; P82986; -.
DR   OMA; MEKVTAC; -.
DR   OrthoDB; 1179236at2759; -.
DR   PhylomeDB; P82986; -.
DR   BioGRID-ORCS; 318778; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 318778; -.
DR   PRO; PR:P82986; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0041621; Expressed in antennal basiconic sensillum ab5 (Drosophila) and 4 other tissues.
DR   ExpressionAtlas; P82986; differential.
DR   Genevisible; P82986; DM.
DR   GO; GO:0032590; C:dendrite membrane; ISS:FlyBase.
DR   GO; GO:0005615; C:extracellular space; HDA:FlyBase.
DR   GO; GO:0016021; C:integral component of membrane; HDA:FlyBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR   GO; GO:0004984; F:olfactory receptor activity; HDA:FlyBase.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; HDA:FlyBase.
DR   GO; GO:0019953; P:sexual reproduction; HEP:FlyBase.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR004117; 7tm6_olfct_rcpt.
DR   PANTHER; PTHR21137; PTHR21137; 1.
DR   Pfam; PF02949; 7tm_6; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Olfaction; Receptor; Reference proteome;
KW   Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..385
FT                   /note="Odorant receptor 82a"
FT                   /id="PRO_0000174270"
FT   TOPO_DOM        1..32
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        54..62
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        84..131
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        153..186
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        208..257
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        279..290
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        312..357
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        379..385
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   385 AA;  43635 MW;  5E8F81219BD3F56D CRC64;
     MGRLFQLQEY CLRAMGHKDD MDSTDSTALS LKHISSLIFV ISAQYPLISY VAYNRNDMEK
     VTACLSVVFT NMLTVIKIST FLANRKDFWE MIHRFRKMHE QSASHIPRYR EGLDYVAEAN
     KLASFLGRAY CVSCGLTGLY FMLGPIVKIG VCRWHGTTCD KELPMPMKFP FNDLESPGYE
     VCFLYTVLVT VVVVAYASAV DGLFISFAIN LRAHFQTLQR QIENWEFPSS EPDTQIRLKS
     IVEYHVLLLS LSRKLRSIYT PTVMGQFVIT SLQVGVIIYQ LVTNMDSVMD LLLYASFFGS
     IMLQLFIYCY GGEIIKAESL QVDTAVRLSN WHLASPKTRT SLSLIILQSQ KEVLIRAGFF
     VASLANFVGI CRTALSLITL IKSIE
 
 
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