OR85E_DROME
ID OR85E_DROME Reviewed; 467 AA.
AC P81924; Q9VHP5;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Putative odorant receptor 85e;
GN Name=Or85e; Synonyms=dor104, OR104;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Oregon-R; TISSUE=Maxillary palp;
RX PubMed=10089887; DOI=10.1016/s0092-8674(00)80582-6;
RA Vosshall L.B., Amrein H., Morozov P.S., Rzhetsky A., Axel R.;
RT "A spatial map of olfactory receptor expression in the Drosophila
RT antenna.";
RL Cell 96:725-736(1999).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=10943836; DOI=10.1016/s0092-8674(00)00021-0;
RA Vosshall L.B., Wong A.M., Axel R.;
RT "An olfactory sensory map in the fly brain.";
RL Cell 102:147-159(2000).
CC -!- FUNCTION: Odorant receptor which mediates acceptance or avoidance
CC behavior, depending on its substrates. The odorant receptor repertoire
CC encodes a large collection of odor stimuli that vary widely in
CC identity, intensity, and duration. May form a complex with Orco to form
CC odorant-sensing units, providing sensitive and prolonged odorant
CC signaling and calcium permeability (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with Orco. Complexes exist early in the endomembrane
CC system in olfactory sensory neurons (OSNs), coupling these complexes to
CC the conserved ciliary trafficking pathway (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in 15% of the 120 sensory neurons within
CC the maxillary palp. {ECO:0000269|PubMed:10089887,
CC ECO:0000269|PubMed:10943836}.
CC -!- MISCELLANEOUS: The atypical heteromeric and topological design of the
CC odorant receptors appears to be an insect-specific solution for odor
CC recognition, making the OR/Orco complex an attractive target for the
CC development of highly selective insect repellents to disrupt olfactory-
CC mediated host-seeking behaviors of insect disease vectors. Odor-evoked
CC OR currents are independent of known G-protein-coupled second messenger
CC pathways.
CC -!- SIMILARITY: Belongs to the insect chemoreceptor superfamily.
CC Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a
CC subfamily. {ECO:0000305}.
CC -!- CAUTION: The strain (Berkeley) sequenced by the collaborative genome
CC project contains a 3' deletion and is considered a pseudogene.
CC {ECO:0000305}.
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DR EMBL; AF127922; AAD26357.1; -; mRNA.
DR RefSeq; NP_001262374.1; NM_001275445.1.
DR AlphaFoldDB; P81924; -.
DR SMR; P81924; -.
DR STRING; 7227.FBpp0301983; -.
DR EnsemblMetazoa; FBtr0310300; FBpp0301983; FBgn0026399.
DR GeneID; 41018; -.
DR KEGG; dme:Dmel_CG9700; -.
DR CTD; 41018; -.
DR FlyBase; FBgn0026399; Or85e.
DR VEuPathDB; VectorBase:FBgn0026399; -.
DR eggNOG; ENOG502SAW0; Eukaryota.
DR HOGENOM; CLU_585637_0_0_1; -.
DR OMA; MFTYCGE; -.
DR OrthoDB; 950164at2759; -.
DR BioGRID-ORCS; 41018; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 41018; -.
DR PRO; PR:P81924; -.
DR Bgee; FBgn0026399; Expressed in maxillary palpus (Drosophila) and 2 other tissues.
DR ExpressionAtlas; P81924; baseline and differential.
DR Genevisible; P81924; DM.
DR GO; GO:0032590; C:dendrite membrane; ISS:FlyBase.
DR GO; GO:0016021; C:integral component of membrane; ISM:FlyBase.
DR GO; GO:0005549; F:odorant binding; ISS:FlyBase.
DR GO; GO:0004984; F:olfactory receptor activity; IC:FlyBase.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISM:FlyBase.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IMP:FlyBase.
DR GO; GO:0007608; P:sensory perception of smell; IEP:FlyBase.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR InterPro; IPR004117; 7tm6_olfct_rcpt.
DR PANTHER; PTHR21137; PTHR21137; 1.
DR Pfam; PF02949; 7tm_6; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Olfaction; Receptor; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..467
FT /note="Putative odorant receptor 85e"
FT /id="PRO_0000174278"
FT TOPO_DOM 1..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..212
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..286
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..334
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 356..367
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 389..467
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 467 AA; 53063 MW; BEE4297A7DFE72A0 CRC64;
MASLQFHGNV DADIRYDISL DPARESNLFR LLMGLQLANG TKPSPRLPKW WPKRLEMIGK
VLPKAYCSMV IFTSLHLGVL FTKTTLDVLP TGELQAITDA LTMTIIYFFT GYGTIYWCLR
SRRLLAYMEH MNREYRHHSL AGVTFVSSHA AFRMSRNFTV VWIMSCLLGV ISWGVSPLML
GIRMLPLQCW YPFDALGPGT YTAVYATQLF GQIMVGMTFG FGGSLFVTLS LLLLGQFDVL
YCSLKNLDAH TKLLGGESVN GLSSLQEELL LGDSKRELNQ YVLLQEHPTD LLRLSAGRKC
PDQGNAFHNA LVECIRLHRF ILHCSQELEN LFSPYCLVKS LQITFQLCLL VFVGVSGTRE
VLRIVNQLQY LGLTIFELLM FTYCGELLSR HSIRSGDAFW RGAWWKHAHF IRQDILIFLV
NSRRAVHVTA GKFYVMDVNR LRSVITQAFS FLTLLQKLAA KKTESEL
